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Protein Alignment Abl and TEC

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_003206.2	Gene:	TEC / 7006	HGNCID:	11719	Length:	631	Species:	Homo sapiens

Alignment Length:	493	Identity:	191/493 - (38%)
Similarity:	286/493 - (58%)	Gaps:	45/493 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 SVFESAHRWTSKENLLAPGP-------------EEDD--PQLFVALYDFQAGGENQLSLKKGEQV 232
            ::|||:.|     ..|.|.|             ||:|  .::.||:|||||...:.|.|::|::.
Human   147 NLFESSIR-----KALPPAPETKKRRPPPPIPLEEEDNSEEIVVAMYDFQAAEGHDLRLERGQEY 206

  Fly   233 RILSYNKSGEWCEAHSDSGNVGWVPSNYVT--PLNSLEKHSWYHGPISRNAAEYLL-SSGINGSF 294
            .||..| ...|..|....||.|::||||||  ..|:|:::.||...::|:.||.|| |....|.|
Human   207 LILEKN-DVHWWRARDKYGNEGYIPSNYVTGKKSNNLDQYEWYCRNMNRSKAEQLLRSEDKEGGF 270

  Fly   295 LVRESESSPGQRSISL--RYEG------RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPH 351
            :||:| |.||..::||  ::.|      |.||.:.:.....|.::.::..|.::.|::.:|.  |
Human   271 MVRDS-SQPGLYTVSLYTKFGGEGSSGFRHYHIKETTTSPKKYYLAEKHAFGSIPEIIEYHK--H 332

  Fly   352 EGHGLITPLLYP--APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWK-RYGN 413
            ...||:|.|.||  ...:|.||....|.|  :|||..:::....:||.|.:|.|....|: :|
Human   333 NAAGLVTRLRYPVSVKGKNAPTTAGFSYE--KWEINPSELTFMRELGSGLFGVVRLGKWRAQY-- 393

  Fly   414 TVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRS-A 477
            .||:|.::|..|..:||:|||.:|.::.||.||||.||||::.|.||:||||..|.||:|||. .
Human   394 KVAIKAIREGAMCEEDFIEEAKVMMKLTHPKLVQLYGVCTQQKPIYIVTEFMERGCLLNFLRQRQ 458

  Fly   478 GRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTA 542
            |..:.|  .||.|...:..||.|||..::||||||||||||.:..:|||:|||:||.:.||.||:
Human   459 GHFSRD--VLLSMCQDVCEGMEYLERNSFIHRDLAARNCLVSEAGVVKVSDFGMARYVLDDQYTS 521

  Fly   543 HAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMER 607
            .:|||||:||..||...|::||:|||||:||||:||:.|.|..|:......:|...:.:|:|:.:
Human   522 SSGAKFPVKWCPPEVFNYSRFSSKSDVWSFGVLMWEVFTEGRMPFEKYTNYEVVTMVTRGHRLYQ 586

  Fly   608 PPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQ 645
            |......||::|.:|||.....||:|:.:...::.:.:
Human   587 PKLASNYVYEVMLRCWQEKPEGRPSFEDLLRTIDELVE 624

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.