Protein Alignment Abl and SRC

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_047296363.1
• Gene: SRC / 6714
• HGNCID: 11283
• Length: 562
• Species: Homo sapiens
• Alignment Length: 644
• Identity: 246/644 - (38%)
• Similarity: 345/644 - (53%)
• Gaps: 109/644 - (16%)

  Fly    14 GG--GGSGAPVSCIGLSSSPVASVSPHCISSSSGVSSAPLGGGSTLRGSRIKSSSSGVASGSGSG 76
            ||  .|.|||.:.    ..||:|:||.....|:  .|.|..      .|:.:.|.....:..|:|
Human     2 GGREAGQGAPAAL----PVPVSSLSPARTMGSN--KSKPKD------ASQRRRSLEPAENVHGAG 54

  Fly    77 GGGGGSGSGLSQRSGGHKDARCNPTVGLNIFTEHNGTKHSSFRGHPGKYHMNLEALLQSRPLPHI 141
            ||.                          .......:|.:|..||.|
Human    55 GGA--------------------------FPASQTPSKPASADGHRG------------------ 75

  Fly   142 PAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDD 206
            |:.:.|.:    |||               ..|.||.:|:.:|       ||.:.   .||....
Human    76 PSAAFAPA----AAE---------------PKLFGGFNSSDTV-------TSPQR---AGPLAGG 111

  Fly   207 PQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHS-DSGNVGWVPSNYVTPLNSLEKH 270
            ...||||||:::..|..||.||||:::|:: |..|:|..||| .:|..|::|||||.|.:|::..
Human   112 VTTFVALYDYESRTETDLSFKKGERLQIVN-NTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAE 175

  Fly   271 SWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISL----RYEG-RVYHYRISEDPDGK 328
            .||.|.|:|..:|.||.:..|  |:|||||||::.|...:|:    ..:| .|.||:|.:...|.
Human   176 EWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGG 240

  Fly   329 VFVTQEAKFNTLAELVHHHSVPHEG--HGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMM 391
            .::|...:||:|.:||.::|...:|  |.|.|  :.|.   :||....|:  .|.|||.|..:.:
Human   241 FYITSRTQFNSLQQLVAYYSKHADGLCHRLTT--VCPT---SKPQTQGLA--KDAWEIPRESLRL 298

  Fly   392 KHKLGGGQYGEVYEAVWKRYGNT-VAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTRE 455
            :.|||.|.:|||:...|.  |.| ||:||||..||:.:.||:||.:||:::|..||||..|.:.|
Human   299 EVKLGQGCFGEVWMGTWN--GTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEE 361

  Fly   456 PPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGD 520
             |.||:||:||.|:|||||:....:.|....|:.||.||||||:|:|..||:||||.|.|.|||:
Human   362 -PIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGE 425

  Fly   521 NKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMS 585
            |.:.||||||||||:.|:.|||..||||||||||||...|.:|:.|||||:||:||.|:.|.|..
Human   426 NLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRV 490

  Fly   586 PYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMF 644
            |||.:...:|..::::||||..||.||..::|||.|||:.:..:||||:.:...||..|
Human   491 PYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYF 549

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	27/54 (50%)
		SH2_ABL	268..363	CDD:198189	36/103 (35%)
		PTKc_Abl	382..644	CDD:270645	136/262 (52%)
		FABD	1584..1723	CDD:197885
SRC	XP_047296363.1	SH3_Src	114..169	CDD:212941	27/55 (49%)
		SH2_Src_Src	173..273	CDD:198228	36/101 (36%)
		PTKc_Src	286..562	CDD:270656	138/267 (52%)