Protein Alignment Abl and BMX

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001712.1
• Gene: BMX / 660
• HGNCID: 1079
• Length: 675
• Species: Homo sapiens
• Alignment Length: 574
• Identity: 194/574 - (33%)
• Similarity: 294/574 - (51%)
• Gaps: 94/574 - (16%)

  Fly   105 NIFTEHNGTKH--SSFRGHPGKYHMNLEALLQSRPLPHI----PAGSTAASLLADAAELQQHQQD 163
            |:.|..|..||  .:|   |.:      .|...|.:|.:    |:.||.         |.|:..:
Human   151 NLHTAVNEEKHRVPTF---PDR------VLKIPRAVPVLKMDAPSSSTT---------LAQYDNE 197

  Fly   164 S-GGLGLQ----GSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQ 223
            | ...|.|    .:||....|::..::.|...:..:..     |.||.|..:
Human   198 SKKNYGSQPPSSSTSLAQYDSNSKKIYGSQPNFNMQYI-----PREDFPDWW------------- 244

  Fly   224 LSLKKGEQVRILSYNKSGE-WCEAHSDSGNVGWVPS--NYVTPLNS-------LEKHSWYHGPIS 278
                   |||.|..:.|.| ...::....||....|  ::..|.:|       |:.:.|:.|.||
Human   245 -------QVRKLKSSSSSEDVASSNQKERNVNHTTSKISWEFPESSSSEEEENLDDYDWFAGNIS 302

  Fly   279 RNAAEYLL-SSGINGSFLVRESESSPGQRSISL------RYEGRVYHYRISEDPDGKVFVTQEAK 336
            |:.:|.|| ..|..|:|:||.| |..|..::||      ..:|.|.||.:..:.:.|:::.:...
Human   303 RSQSEQLLRQKGKEGAFMVRNS-SQVGMYTVSLFSKAVNDKKGTVKHYHVHTNAENKLYLAENYC 366

  Fly   337 FNTLAELVHHHSVPHEGHGLITPLLYP-APKQNKPTVFPLSPEPDE-------WEICRTDIMMKH 393
            |:::.:|:|:|.  |...|:||.|.:| :.|.||        .||.       ||:.|.:|.:..
Human   367 FDSIPKLIHYHQ--HNSAGMITRLRHPVSTKANK--------VPDSVSLGNGIWELKREEITLLK 421

  Fly   394 KLGGGQYGEVYEAVWK-RYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPP 457
            :||.||:|.|....|| :|  .||||.:||.:|:..:|.:||..|.::.||.||:..|||::|.|
Human   422 ELGSGQFGVVQLGKWKGQY--DVAVKMIKEGSMSEDEFFQEAQTMMKLSHPKLVKFYGVCSKEYP 484

  Fly   458 FYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNK 522
            .||:||::|:|.||::|||.|: .|:...||.|...:..||::|||..:||||||||||||..:.
Human   485 IYIVTEYISNGCLLNYLRSHGK-GLEPSQLLEMCYDVCEGMAFLESHQFIHRDLAARNCLVDRDL 548

  Fly   523 LVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPY 587
            .|||:|||:.|.:.||.|.:..|.|||:||:|||...|.|:|:||||||||:|:||:.:.|..||
Human   549 CVKVSDFGMTRYVLDDQYVSSVGTKFPVKWSAPEVFHYFKYSSKSDVWAFGILMWEVFSLGKQPY 613

  Fly   588 PAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 641
            ...|.:.|..|:.:|:|:.||......:|.:|..||......||||:.:..::|
Human   614 DLYDNSQVVLKVSQGHRLYRPHLASDTIYQIMYSCWHELPEKRPTFQQLLSSIE 667

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	9/56 (16%)
		SH2_ABL	268..363	CDD:198189	32/101 (32%)
		PTKc_Abl	382..644	CDD:270645	118/261 (45%)
		FABD	1584..1723	CDD:197885
BMX	NP_001712.1	PH_Btk	7..147	CDD:269944
		SH2_Tec_Bmx	289..394	CDD:198262	34/107 (32%)
		PTKc_Btk_Bmx	412..667	CDD:173657	115/257 (45%)
		CAV1-binding	596..603		5/6 (83%)