Protein Alignment Abl and Map3k20

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_075544.1
• Gene: Map3k20 / 65964
• MGIID: 2443258
• Length: 802
• Species: Mus musculus
• Alignment Length: 924
• Identity: 210/924 - (22%)
• Similarity: 336/924 - (36%)
• Gaps: 244/924 - (26%)

  Fly   388 DIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVC 452
            |:......|||.:|.||.|.|......||||.|      || ..:||.|:..:.|.|::|..||.
Mouse    15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL------LK-IEKEAEILSVLSHRNIIQFYGVI 72

  Fly   453 TREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESR---NYIHRDLAAR 514
            ...|.:.|:||:.|.|:|.|::.|...|.:|...::..||.:|.||.||...   ..|||||.:|
Mouse    73 LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSR 137

  Fly   515 NCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEI 579
            |.::..:.::|:.|||.:|.....|:.:..|. ||  |.|||.:.....|...|.:::||:|||:
Mouse   138 NVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVSETCDTYSYGVVLWEM 199

  Fly   580 ATYGMSPYPAID-LTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHM 643
            .|..: |:..:: |...:..::|..|:..|..||....:|:.|||:.||..||:||.|...||.|
Mouse   200 LTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263

  Fly   644 FQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKK 708
            ..::::.:.....|:..|........:...:                  ......||...|.:|:
Mouse   264 SNDTNLPDQCNSFLHNKAEWRCEIEATLERL------------------KKLERDLSFKEQELKE 310

  Fly   709 G----LPGGQALTPNAHHNDPHQQQASTPMSET---------------------GSTSTKLSTFS 748
            .    ....|.||          :|::||:..:                     |.:|.::|.::
Mouse   311 RERRLKMWEQKLT----------EQSNTPLLPSFEIGAWTEDDVYFWVQQLVRKGESSVEMSGYA 365

  Fly   749 SQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLSTNGIHKLKTA 813
            |..|.|       |..|       ||..||        .|||                   ||..
Mouse   366 SLFKEN-------NITG-------KRLLLL--------EEED-------------------LKDM 389

  Fly   814 NYFSQTLSRNFKTQIPT---------HHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAH------ 863
            ...|:....:||:.|..         |....|:....:.:::   :::||.|.:....|
Mouse   390 GIVSKGHIIHFKSAIEKLTHDYLNLFHFPPLIKDSGGEPEEN---EEKIVNLELVFGFHLKPGTG 451

  Fly   864 QQQQKQQQY-SIKKSSSCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLS 927
            .|..|.:.| .:.......:::.|:.|.....|...|..     |.|....:....|.:.:|::.
Mouse   452 PQDCKWKMYMEMDGDEVAITYIKDVTFNTSLPDAEILKM-----TKPPFVMEKWIVGIAEDQTVE 511

  Fly   928 QVIA------APVTNKMQHSLHSGGGGGGIGPRSSQQ----------HSSFKRPTGTPVMGNRG- 975
            ..:.      .|...|..||:.        ..|:..|          .:.|....|.|  |:|.
Mouse   512 CTVTYENDVRTPKLTKHVHSIQ--------WDRTKPQDEVKAVQLAIQTLFSSSEGNP--GSRSD 566

  Fly   976 -------LETRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGT 1033
                   |:|.:.::...|:        |.|....|        ||.
Mouse   567 SSADCQWLDTLRMRQIASHT--------SLQRSQSN--------PIL------------------ 597

  Fly  1034 LPKGARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARLNPKASPIPPQQ-MIRSNSSG 1097
               |:....|..: :||..||.....|    |......||   .:||..|..|.|. :.|:.||.
Mouse   598 ---GSPFFPYFAN-QDSYAAAVRRTQT----PVKYQQITP---SINPSRSSSPTQYGLSRNFSSL 651

  Fly  1098 GVTMQNNAAASLN--KLQRHRTTT-------EGTMMTFSS--FRAGGSS--SSPKRSA-SGVASG 1148
            .::.:::..:|||  ..:|.|.:.       .|::...||  .|.||.|  |:|.|.. ||....
Mouse   652 NLSSRDSGFSSLNDSSSERGRYSDRSRNKYYRGSVSLNSSPKGRYGGKSQHSTPSRERYSGKFYR 716

  Fly  1149 VQPALANLEFPPPPLDLPPPPEEFEGGPPPPPPA----PESAVQAIQQHLHAQLPNNGNISNGNG 1209
            :..:..|....|   |....|.:.:...|...|.    ||:|.:|.::        ...:|.|..
Mouse   717 LPQSALNTHQSP---DFKRSPNDHDRRVPRTIPGMPLHPETASKAGEE--------ESRVSEGGW 770

  Fly  1210 T--NNNDSSHNDVS 1221
            |  .....:|..:|
Mouse   771 TKVEYRKKTHRQLS 784

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	90/259 (35%)
		FABD	1584..1723	CDD:197885
Map3k20	NP_075544.1	STKc_MLTK	22..263	CDD:270962	89/251 (35%)
		Leucine-zipper	287..308		3/38 (8%)
		SAM_MLTK	338..408	CDD:188928	21/110 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	624..802		42/175 (24%)
		Sensing domain (S). /evidence=ECO:0000250|UniProtKB:Q9NYL2	670..713		13/42 (31%)
		C-terminal domain (CTD). /evidence=ECO:0000250|UniProtKB:Q9NYL2	776..802		2/9 (22%)