DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and WNK4

DIOPT Version :9

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:XP_016880451.1 Gene:WNK4 / 65266 HGNCID:14544 Length:1302 Species:Homo sapiens


Alignment Length:1317 Identity:280/1317 - (21%)
Similarity:433/1317 - (32%) Gaps:400/1317 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   394 KLGGGQYGEVY---------EAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLI 449
            ::|.|.:..||         |..|      ..::|.|......:.|.||..::|.::|||:|:..
Human   179 EIGRGSFKTVYRGLDTDTTVEVAW------CELQTRKLSRAERQRFSEEVEMLKGLQHPNIVRFY 237

  Fly   450 G---------VCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESR- 504
            .         ||     ..::||.|:.|.|..:||.. ||....| |...:.||..|:.:|.|| 
Human   238 DSWKSVLRGQVC-----IVLVTELMTSGTLKTYLRRF-REMKPRV-LQRWSRQILRGLHFLHSRV 295

  Fly   505 -NYIHRDLAARNCLV-GDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKS 567
             ..:||||...|..: |....||:.|.|||.|.|.....:..|..   ::.||| :...|:....
Human   296 PPILHRDLKCDNVFITGPTGSVKIGDLGLATLKRASFAKSVIGTP---EFMAPE-MYEEKYDEAV 356

  Fly   568 DVWAFGVLLWEIATYGMSPYP---AIDLTDVYHKLDKGYRMERPPGC-----PPEVYDLMRQCWQ 624
            ||:|||:.:.|:||   |.||   ..:...:|.|:..|    |.|..     .|||.:::..|.:
Human   357 DVYAFGMCMLEMAT---SEYPYSECQNAAQIYRKVTSG----RKPNSFHKVKIPEVKEIIEGCIR 414

  Fly   625 WDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSSAPSTSGV--------ATGGGAT 681
            .|..:|.|.:.:   |.|.|        ..::...:...|........|:        |..||..
Human   415 TDKNERFTIQDL---LAHAF--------FREERGVHVELAEEDDGEKPGLKLWLRMEDARRGGRP 468

  Fly   682 TTTAASGCASSSSATASLSLTPQMVKKGL-------PGGQALTPNAHHNDPHQQQASTPMSETGS 739
            ....|..........|:..:..:||..||       |..:|:         .::.|:        
Human   469 RDNQAIEFLFQLGRDAAEEVAQEMVALGLVCEADYQPVARAV---------RERVAA-------- 516

  Fly   740 TSTKLSTFSSQGKGNVQMRRTTNKQGKQ------APAPPKRTSLLSSSRDSTY---REEDPANAR 795
                           :|.:|...::.::      .|.||..|..::....|.:   .||..|:..
Human   517 ---------------IQRKREKLRKARELEALPPEPGPPPATVPMAPGPPSVFPPEPEEPEADQH 566

  Fly   796 CNFI----------DDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQ 850
            ..|:          .|..|:|.  |.::.:...:                         ....|.
Human   567 QPFLFRHASYSSTTSDCETDGY--LSSSGFLDAS-------------------------DPALQP 604

  Fly   851 QQIVPLSVQQQAHQQQQKQQQYSIKKSSSC--SSFLYDILFRGLARDINSLTQRYDSETDPAADP 913
            ...||                .|:.:|..|  |:|...|                     |.:.|
Human   605 PGGVP----------------SSLAESHLCLPSAFALSI---------------------PRSGP 632

  Fly   914 DTD-ATGDS----LEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGN 973
            .:| :.|||    ....||.|                  |.|:|        ..:||.|      
Human   633 GSDFSPGDSYASDAASGLSDV------------------GEGMG--------QMRRPPG------ 665

  Fly   974 RGLETRQSKRSQLHS---QAPGPGPPSTQPHHGNNGVVT------SAHPITVGALDVMN------ 1023
            |.|..|...|.::.|   |.........|.|  |:.:||      ...|..:.|..|.|      
Human   666 RNLRRRPRSRLRVTSVSDQNDRVVECQLQTH--NSKMVTFRFDLDGDSPEEIAAAMVYNEFILPS 728

  Fly  1024 --------VKQVVNRYGTLPK--GARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARL 1078
                    :::::.|..||.|  ...:.|..|:|....|.|| |||.                  
Human   729 ERDGFLRRIREIIQRVETLLKRDTGPMEAAEDTLSPQEEPAP-LPAL------------------ 774

  Fly  1079 NPKASPIPPQQMIRSNSSGGVTMQNNAAASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSAS 1143
             |...|.|..:.::|::|                ..||:.|     .||:     |||||     
Human   775 -PVPLPDPSNEELQSSTS----------------LEHRSWT-----AFST-----SSSSP----- 807

  Fly  1144 GVASGVQPALANLEFPPPPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQHLHAQLPNNGNISNGN 1208
                |...:..|...|..|:. |.|.......|..|.|:|.|             |.:..:|   
Human   808 ----GTPLSPGNPFSPGTPIS-PGPIFPITSPPCHPSPSPFS-------------PISSQVS--- 851

  Fly  1209 GTNNNDSSHNDVSNIAPSVEEASSRFGV--------SLRKREPSTDS--CS--SLGSP-----PE 1256
               :|.|.|...|.:..|  .::..|.|        ||....|.|.|  ||  :|.||     |.
Human   852 ---SNPSPHPTSSPLPFS--SSTPEFPVPLSQCPWSSLPTTSPPTFSPTCSQVTLSSPFFPPCPS 911

  Fly  1257 DLKEKLITEIKAAGKDTAPASHLANGSGIAVVDPVSLLVTE----LAES--------MNLPKPPP 1309
            .......|        .||...||:...:||:.....|::.    |::|        .:||.|||
Human   912 TSSFPSTT--------AAPLLSLASAFSLAVMTVAQSLLSPSPGLLSQSPPAPPSPLPSLPLPPP 968

  Fly  1310 QQQQKLTNGNSTGSGFKAQLKKVEPKKMSAPMP-KAEPANTIIDFKAHL---RRVDKEKEPATPA 1370
                ....|..:.|...|:::.......:.|:| :|..|....:.|..|   .:|...||||.|.
Human   969 ----VAPGGQESPSPHTAEVESEASPPPARPLPGEARLAPISEEGKPQLVGRFQVTSSKEPAEPL 1029

  Fly  1371 P-APATVAVANNANCNTTGTLNRKEDGSKKFSQAMQKTEIKIDVTNSNVEADAGAAGEGDLGKRR 1434
            | .|.:..::.:...:|....:...|.........:..|...:...:.....||...|||.||..
Human  1030 PLQPTSPTLSGSPKPSTPQLTSESSDTEDSAGGGPETREALAESDRAAEGLGAGVEEEGDDGKEP 1094

  Fly  1435 STGSINSLKKLWEQQPPAPDYATSTILQQQPSVVNGGGTPN--AQLSPKYGMKSGAINTVGTLPA 1497
            ..|  .|.:.|....|...:|:.|::........:.|....  |:|..........:.|:.||..
Human  1095 QVG--GSPQPLSHPSPVWMNYSYSSLCLSSEESESSGEDEEFWAELQSLRQKHLSEVETLQTLQK 1157

  Fly  1498 K--------LGNKQPPAAPPPPPPNCTTSNS--STTSISTSSRDCTSRQQ--ASSTIKTSHSTQL 1550
            |        || ||||.....|....::...  |..|..||.|:...|.:  ....::.:..:..
Human  1158 KEIEDLYSRLG-KQPPPGIVAPAAMLSSRQRRLSKGSFPTSRRNSLQRSEPPGPGIMRRNSLSGS 1221

  Fly  1551 FTDDEEQSHTEGLGSGG 1567
            .|..:||..::|:...|
Human  1222 STGSQEQRASKGVTFAG 1238

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189
PTKc_Abl 382..644 CDD:270645 79/278 (28%)
Pkinase_Tyr 389..640 CDD:285015 77/274 (28%)
FABD 1584..1723 CDD:197885
WNK4XP_016880451.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
00.000

Return to query results.
Submit another query.