Protein Alignment Abl and Matk

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_038935769.1
• Gene: Matk / 60450
• RGDID: 69058
• Length: 496
• Species: Rattus norvegicus
• Alignment Length: 529
• Identity: 173/529 - (32%)
• Similarity: 256/529 - (48%)
• Gaps: 86/529 - (16%)

  Fly   190 RWTSKENLLAPGP------EEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEA-H 247
            ||       |||.      |...|:            ..:|:.:||:.|.||...:...|..| |
  Rat     5 RW-------APGTQCMTKCENSRPK------------PGELAFRKGDMVTILEACEDKSWYRAKH 50

  Fly   248 SDSGNVGWVPSNYVTPLNSLEKH------SWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQR 306
            ..||..|.:.:..:....:|...      .|:||.||...|...|....:|.||||||...||..
  Rat    51 HSSGQEGLLAAAALRQREALSTDPKLSLMPWFHGKISGQEAIQQLQPPEDGLFLVRESARHPGDY 115

  Fly   307 SISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPT 371
            .:.:.:...|.|||:.. .||.:.:.:...|..|.::|.|::  .:...:.|.|:.|..||...
  Rat   116 VLCVSFGRDVIHYRVLH-RDGHLTIDEAVCFCNLMDMVEHYT--RDKGAICTKLVKPKRKQGAK- 176

  Fly   372 VFPLSPEPD----EWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLE 432
                |.|.:    .|.:....:.:..::|.|::|.|.:..:  .|..||||.:|.|..| :.||:
  Rat   177 ----SAEEELAKAGWLLDLQHLTLGAQIGEGEFGAVLQGEY--LGQKVAVKNIKCDVTA-QAFLD 234

  Fly   433 EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASG 497
            |.|:|.:::|.|||:|:||.... ..||:.|.:|.|||::|||:.||..:....||..|..:|.|
  Rat   235 ETAVMTKLQHRNLVRLLGVILHH-GLYIVMEHVSKGNLVNFLRTRGRALVSTSQLLQFALHVAEG 298

  Fly   498 MSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNK 562
            |.||||:..:||||||||.||.::.:.||:|||||:.   :.......::.|:||||||.|...:
  Rat   299 MEYLESKKLVHRDLAARNILVSEDLVAKVSDFGLAKA---ELRKGLDSSRLPVKWTAPEALKNGR 360

  Fly   563 FSTKSDVWAFGVLLWEIATYGMSPYPAI-----------------------------DLTDVYHK 598
            ||:|||||:|||||||:.:||.:|||.:                             .|.:|...
  Rat   361 FSSKSDVWSFGVLLWEVFSYGRAPYPKMVSSTPGRAACASRVTDCPHPCYPLPPYLQSLKEVSEA 425

  Fly   599 LDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATS 663
            ::||||||.|..||..|:.||..||:.:.:.||.|:.|   :|.:.:|   ..:|.....|....
  Rat   426 VEKGYRMEPPDSCPGPVHTLMGSCWEAEPSRRPPFRKI---VEKLGRE---LRSVGVAAPAGGQE 484

  Fly   664 ASSSAPSTS 672
            |..|||:.|
  Rat   485 AEGSAPTRS 493

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	12/54 (22%)
		SH2_ABL	268..363	CDD:198189	28/100 (28%)
		PTKc_Abl	382..644	CDD:270645	112/290 (39%)
		FABD	1584..1723	CDD:197885
Matk	XP_038935769.1	SH3	9..67	CDD:473055	15/69 (22%)
		SH2_csk_like	77..174	CDD:198190	30/99 (30%)
		Protein Kinases, catalytic domain	187..470	CDD:473864	112/292 (38%)