Protein Alignment Abl and fgfr1b

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001155204.1
• Gene: fgfr1b / 567905
• ZFINID: ZDB-GENE-060503-14
• Length: 740
• Species: Danio rerio
• Alignment Length: 681
• Identity: 189/681 - (27%)
• Similarity: 283/681 - (41%)
• Gaps: 185/681 - (27%)

  Fly    88 QRSGGHKDARCNPTVGLN-------------IFTEHNGTKHSSFRGHPGKYHMNLEALLQSRPLP 139
            ||.||:|......|:.:.             :..|:....|:        |.:::......||:.
Zfish   121 QRIGGYKLREHMWTIIMESVVPSDKGNYTCLVENEYGSINHT--------YQLDVVERSPHRPIL 177

  Fly   140 H--IPAGSTA---------ASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTS 193
            :  :||..||         ..:.:|.   |.|.|....:.:.||.||........|.::|
Zfish   178 YAGLPANRTAVVGSDVEFVCKVFSDP---QPHIQWLKHIRVNGSQLGPDGLPYVRVLKTA----- 234

  Fly   194 KENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEW-CEAHSDSGNVGWVP 257
                   |....|.::.|.                  |:|.:|:..:||: |.|.:..|
Zfish   235 -------GLNTTDKEMEVL------------------QLRNVSFEDAGEYTCLAGNSIG------ 268

  Fly   258 SNYVTPLNSLEKHS-W---YHGPISRNAA---EYL-------------LSSGINGSFLVRES--- 299
                     :..|| |   ...|.:.:|.   .||             |..||.....:|.|
Zfish   269 ---------ISHHSAWLTVVKAPTAPSAVPSQSYLEVLIYCIGFFLIFLMVGIATIVKIRSSSKK 324

  Fly   300 -------------ESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPH 351
                         :|.|.:|.|:                   |.|...:..|:...||....:..
Zfish   325 SDFNSQLAVHKLAKSIPLRRQIT-------------------VSVESSSSLNSGVMLVRPSRLSS 370

  Fly   352 EGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVY--EAVW--KRYG 412
            .|    ||:|      :..:.:.|..:|. ||:.|..:::...||.|.:|:|.  ||:.  |...
Zfish   371 SG----TPML------SGVSEYELPQDPC-WEVSRERLVLGKPLGEGCFGQVVMGEAIGLDKDKP 424

  Fly   413 N---TVAVKTLKEDTMA--LKDFLEEAAIMKEM-KHPNLVQLIGVCTREPPFYIITEFMSHGNLL 471
            |   .||||.||.|...  |.|.:.|..:||.: ||.|::.|:|.||::.|.|:|.||.|.|||.
Zfish   425 NRITKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGACTQDGPLYVIVEFASKGNLR 489

  Fly   472 DFLRSAGR---------------ETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDN 521
            ::|| |.|               |::....|:..|.|:|.||.||.|:..|||||||||.||.::
Zfish   490 EYLR-ARRPHGMEYCYNPDPLPIESMSIKDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTED 553

  Fly   522 KLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMS 585
            .::|:||||||| :...|.|......:.|:||.|||.|....::.:||||:||||||||.|.|.|
Zfish   554 NVMKIADFGLARDVHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGS 618

  Fly   586 PYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSIT 650
            |||.:.:.:::..|.:|:||::|..|..|:|.:|:.||....|.|||||.:...|:......|..
Zfish   619 PYPGVPVEELFKLLREGHRMDKPSACTQELYLMMKDCWHAVPTQRPTFKQLVEDLDRTLSLISNQ 683

  Fly   651 EAVEKQ-----------LNANATSASSSAPS 670
            |.:|..           ||..:::.||...|
Zfish   684 EYLELSVPLEPMYSQVILNERSSTCSSEQDS 714

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	9/54 (17%)
		SH2_ABL	268..363	CDD:198189	25/130 (19%)
		PTKc_Abl	382..644	CDD:270645	118/287 (41%)
		FABD	1584..1723	CDD:197885
fgfr1b	NP_001155204.1	IgI_2_FGFR	73..167	CDD:409443	9/53 (17%)
		Ig strand A	73..76	CDD:409443
		Ig strand A'	84..89	CDD:409443
		Ig strand B	93..101	CDD:409443
		Ig strand C	107..112	CDD:409443
		Ig strand C'	115..117	CDD:409443
		Ig strand D	126..129	CDD:409443	1/2 (50%)
		Ig strand E	133..138	CDD:409443	1/4 (25%)
		Ig strand F	147..154	CDD:409443	0/6 (0%)
		Ig strand G	157..167	CDD:409443	2/17 (12%)
		Ig	175..278	CDD:472250	29/150 (19%)
		Ig strand B	193..197	CDD:409353	0/3 (0%)
		Ig strand C	206..210	CDD:409353	2/3 (67%)
		Ig strand E	244..248	CDD:409353	1/21 (5%)
		Ig strand F	258..263	CDD:409353	2/4 (50%)
		Ig strand G	271..274	CDD:409353	1/2 (50%)
		Protein Kinases, catalytic domain	383..684	CDD:473864	121/302 (40%)