Protein Alignment Abl and fes

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_005166438.1
• Gene: fes / 566739
• ZFINID: ZDB-GENE-100812-10
• Length: 835
• Species: Danio rerio
• Alignment Length: 540
• Identity: 183/540 - (33%)
• Similarity: 274/540 - (50%)
• Gaps: 93/540 - (17%)

  Fly   145 STAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQL 209
            ||.:|..|...:|:...||              ...:.::.:..::: ||.|.|     ||..|.
Zfish   326 STLSSQQATVNQLELDLQD--------------EERSANIGQRVYQF-SKRNAL-----EDSRQQ 370

  Fly   210 FV--------------ALYD-FQAGGENQL-SL-KKGEQVRILSYNKSGEWCEAHSD-------- 249
            .|              .|.| .|..|.|:| || ...:::.:.|.|...:....|.:
Zfish   371 VVLSMVVRARLEAQRRLLADKLQCLGTNELPSLGLDDDRISLTSSNSERDKDHKHLNIDVIRNHL 435

  Fly   250 --------SGNVGWVPSNY---VTPLNSLEK----HSWYHGPISRNAAEYLLSSGINGSFLVRES 299
                    :.:|.:.|...   :||:..:||    ..||||.|.|...:.||.:  :|.||||||
Zfish   436 SSLFKPKYTSSVFYTPQQVPPALTPVPDVEKPLTQQVWYHGAIPRMEVQELLKN--DGDFLVRES 498

  Fly   300 ESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITP----- 359
            :... :..:|:.:.|:..|:.| :..|| |:......|.::..||:|   ....|..:|.
Zfish   499 QGKQ-EYVLSVHWGGQCRHFLI-QSTDG-VYRLDGEGFISVPLLVNH---LFNSHQTVTKRTEIV 557

  Fly   360 LLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDT 424
            |..|.||             |:|.:...|:::...:|.|.:|||:....:.....||||..:|:.
Zfish   558 LKKPIPK-------------DKWVLEHDDVILGQSIGRGNFGEVFSGRLRSDNTPVAVKACRENL 609

  Fly   425 MA--LKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVAL 487
            .|  ...||.||.|:|:..|||:|:||||||::.|.|||.|.:..|:.|.|||:.| ..|.:..|
Zfish   610 PAEHKNKFLMEARILKQYDHPNIVKLIGVCTQKQPIYIIMELVQGGDFLTFLRTEG-HNLKSSML 673

  Fly   488 LYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAK-FPIK 551
            :.||..:|||::||||:..||||:||||||||:..:||::|||::|..:|..|:|..|.| .|:|
Zfish   674 IRMAENVASGLAYLESKKCIHRDVAARNCLVGEESVVKISDFGMSREEQDGVYSATGGMKQIPVK 738

  Fly   552 WTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPY--PAI-DLTDVYHKLDKGYRMERPPGCPP 613
            |||||.|.|.:::|:||||:|||||||..:.|::||  |.: .......::::||||..|..||.
Zfish   739 WTAPEALNYGRYTTESDVWSFGVLLWETFSRGVTPYTIPTVMSNQQTRDEVERGYRMPAPNNCPD 803

  Fly   614 EVYDLMRQCWQWDATDRPTF 633
            |:|.||.||||:|...||:|
Zfish   804 EIYTLMCQCWQYDPRKRPSF 823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	14/89 (16%)
		SH2_ABL	268..363	CDD:198189	31/103 (30%)
		PTKc_Abl	382..644	CDD:270645	118/258 (46%)
		FABD	1584..1723	CDD:197885
fes	XP_005166438.1	F-BAR_Fes	7..243	CDD:153369
		SH2_Fps_family	466..550	CDD:198224	28/91 (31%)
		Protein Kinases, catalytic domain	577..831	CDD:473864	116/248 (47%)