Protein Alignment Abl and tnk1

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001073486.3
• Gene: tnk1 / 565029
• ZFINID: ZDB-GENE-030131-7427
• Length: 733
• Species: Danio rerio
• Alignment Length: 623
• Identity: 176/623 - (28%)
• Similarity: 258/623 - (41%)
• Gaps: 132/623 - (21%)

  Fly   388 DIMMKHKLGGGQYGEVYEAVWKR-YGNT--VAVKTLKEDTMAL-KDFLEEAAIMKEMKHPNLVQL 448
            :::...:||.|.:|.|.:|.|.. .|..  ||||||:...:.| .|||:|...|:.:.|||::.|
Zfish   111 ELLFGDRLGSGSFGVVRKAEWHTPTGRVLPVAVKTLRSGQVDLVSDFLQEVTSMQSLDHPNIIHL 175

  Fly   449 IGVCTREPPFYIITEFMSHGNLLDFLR-SAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLA 512
            .||.... |..::||....|:|.|.|| ..|...|..:.|  .:||||:||.|||||.:||||||
Zfish   176 YGVVLTH-PLKMVTELAPLGSLYDTLRLRHGEYPLSRLWL--FSTQIAAGMEYLESRRFIHRDLA 237

  Fly   513 ARNCLVGDNKLVKVADFGLARLMRD-DTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLL 576
            |||.|:...:.||:.||||.|.:.| |.|...|..:.|..|.|||.|....||..||||.|||.|
Zfish   238 ARNVLLAAREQVKIGDFGLMRGLDDRDHYIMTAHRRIPFAWCAPESLRTGSFSHASDVWMFGVTL 302

  Fly   577 WEIATYGMSPYPAIDLTDVYHKLDK-GYRMERPPGCPPEVYDLMRQCWQWDATDRPTF------- 633
            ||:.||...|:..:....:.::::: |.|:||||.||.|:|.:||:||..::|:||||
Zfish   303 WEMFTYCEEPWLGLSGRQILYRVEREGERLERPPDCPQELYAVMRKCWACNSTERPTFAQLTTMV 367

  Fly   634 -----------KSIHHALEHMFQESSITEAVE--------KQLNANATSA-----SSSAPSTSGV 674
                       |.|........|.:.:...::        |..|....|.     :.:||:.:.|
Zfish   368 SEAQPMEVRSVKDIAEPRRLSLQANDLVTVIDHGLDMCEWKGQNQRTLSVGWFPPALTAPALTAV 432

  Fly   675 ATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGS 739
            ....|.|..        ||....||..|......  ||....||. ..:|..:.:......:.||
Zfish   433 VPASGPTLI--------SSPVRGSLHHTGHGDTD--PGRSRGTPE-RIDDNRRWRVPLAKEKEGS 486

  Fly   740 TSTKLSTFS-----------SQGKG---NVQMR--RTTNKQGKQAPAPPKRTS---LLSSSRDST 785
            ...|::..|           .:|:|   |...|  :..|.|.......|:|.|   ::...|
Zfish   487 NLKKMAGMSRSLESVLGGPQDKGRGVGVNAAQRSDQRRNMQNNNVIQDPRRFSDAVVIPPPR--- 548

  Fly   786 YREEDPANAR-------CNFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQ 843
               ..|.|.:       ..|:|..:.|                       |:..:.|.:.|.|.|
Zfish   549 ---PPPPNIKSIKPQMMMMFLDRRAAN-----------------------PSGWSPQTQAQPQFQ 587

  Fly   844 QQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLYDILFRGLARDINSLTQRYDSETD 908
                .|||.:...::.:..|..:...|             |.|.:.:...|:.....:|...:..
Zfish   588 ----PQQQGLGTSNLTRMTHLAKSSPQ-------------LDDAIEKDKEREKEQEREREREKGK 635

  Fly   909 PAADPDTDATGDSLEQSLSQVIAA--PVTN-KMQHSLH 943
            ....|..|.     |..::||.||  .||| ::|.:||
Zfish   636 ERYPPLVDK-----EAVIAQVQAAVHGVTNEEVQKALH 668

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	111/280 (40%)
		FABD	1584..1723	CDD:197885
tnk1	NP_001073486.3	None