Protein Alignment Abl and tnk2b

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_021336227.1
• Gene: tnk2b / 559119
• ZFINID: ZDB-GENE-110411-165
• Length: 1118
• Species: Danio rerio
• Alignment Length: 1124
• Identity: 258/1124 - (22%)
• Similarity: 374/1124 - (33%)
• Gaps: 380/1124 - (33%)

  Fly   363 PAPKQNKPTVFPLSPEPDEWE------ICRTDIMMKHKLGGGQYGEVYEAVWKRYGN---TVAVK 418
            |.|......:.|..|..|..:      |...|:.:..|||.|.:|.|....|.....   .||||
Zfish   117 PQPASTFRKLSPTPPLVDGQQQALTCLISEKDLALFEKLGDGSFGVVKRGEWFTPNGKVLNVAVK 181

  Fly   419 TLKEDTM----ALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGR 479
            .||.|.:    ||.||:.|...|..:.|.||::|.||.... |..::||....|::||.||....
Zfish   182 CLKTDVLNQPDALDDFIREVNAMHSLDHQNLIRLYGVVLTH-PMKMVTELAPLGSMLDRLRKTLG 245

  Fly   480 ETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLM--RDDTYTA 542
            ..|.:....| ..||::||.||||:.:|||||||||.|:..::.||:.||||.|.:  .||.|..
Zfish   246 HFLISTLCQY-TIQISNGMGYLESKRFIHRDLAARNILLASSEQVKIGDFGLMRALPKNDDHYVM 309

  Fly   543 HAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDK-GYRME 606
            ....|.|..|.|||.|....||..:|.|.|||.|||:.|||..|:..::.:.:.||:|| |.|:.
Zfish   310 QEHRKVPFAWCAPESLKTRTFSHATDTWMFGVTLWEMFTYGQEPWLGLNGSQILHKIDKEGERLP 374

  Fly   607 RPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL-EHM------FQESSITEAVEKQLNANATSA 664
            :|..||.::|::|.|||.....|||||.::...| |.|      .|:....:.::.|::...|..
Zfish   375 KPEDCPQDLYNVMMQCWAQKPDDRPTFVALREFLVETMPTDMRALQDFDEPDKLQIQMDDVITII 439

  Fly   665 SSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQ 729
            ...|.:    ....|....|...|....::.|:...|                 :||       .
Zfish   440 EGRAEN----YWWRGQNKRTLKVGQFPRNTVTSVAGL-----------------SAH-------D 476

  Fly   730 ASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANA 794
            .|.|:.         ::|...|.|:      ||..
Zfish   477 ISRPLK---------NSFIHTGHGD------TNPH------------------------------ 496

  Fly   795 RC----NFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVP 855
            ||    :.||||...  :.:...:.....|:....||:|.      |.:::...:..|.     |
Zfish   497 RCWGFPDRIDDLYLG--NPMDPPDVLGLDLNSARPTQLPG------RAKKEPPPRPPQP-----P 548

  Fly   856 LSVQQQAHQQQQKQQQYSIKKSSSC--SSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDAT 918
            |.|:.:.....|       .|..||  .|.|..::                      .:|..||.
Zfish   549 LLVKSKCGPSVQ-------FKHCSCPLCSLLAPLI----------------------KEPCYDAV 584

  Fly   919 GDSLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGLE------ 977
            .:..||:.|.:                            :..|.|:         :||:
Zfish   585 AEDEEQTYSAL----------------------------RRLSLKK---------KGLKLKPAAW 612

  Fly   978 ---TRQSKRSQLHSQAPGPGPPS--TQPHHGNNGVVTSAHPITVG----------ALDVMNV--- 1024
               ||...||...::.||...|:  :....|......::.|..|.          |||..|:
Zfish   613 VSATRLGDRSSYGARTPGGSTPTEVSLIDFGEEYPSATSSPSPVAEIQIPTLAKLALDAENILDR 677

  Fly  1025 --KQVVNRYGTLPKGARIGAYLDSLEDSSEAAPALPATAPSLPP--------------------- 1066
              .|..:|  |||:             .....|.:...|..|||
Zfish   678 TPPQSPSR--TLPR-------------PLHPTPVVDWDARPLPPPPAYDDVAQDEDDFEVSSINS 727

  Fly  1067 ---ANGHATPPAARLNPKASPIPPQQ---MIRSNSSGGVTMQNNAAASLNKLQ----RH-----R 1116
               |:|....|.|...|.....|..:   .:....|...|. :.:|....:||    ||     .
Zfish   728 AERADGEPCSPHAPCTPTGESKPHVEDNLFLPCRLSNACTF-SQSAEIFQELQQECMRHLKVPVN 791

  Fly  1117 TTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPALANLEFPPPPLDLPPPPEEFEGG------ 1175
            :|:.|.              .|.|......|..:|.:      ||.:.:||.|.:..||
Zfish   792 STSPGL--------------EPHRQIVLTFSEDKPQI------PPRIPIPPRPVKRAGGDYSRLS 836

  Fly  1176 ---------------PPP-PPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVSNIA 1224
                           ||. ||..|.|.            |.:...|...|:....||....::|
Zfish   837 GDLSPVFGNEDDKERPPQIPPRDPFSQ------------PGSRTPSPHVGSPQTRSSLCSAASI- 888

  Fly  1225 PSVEEASSRFGVSLRKREPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPASHLANGSGIAVVD 1289
                ..||....|..|..|:|   .|..|.|:....|:   |:|.|||..|..           .
Zfish   889 ----YGSSYLSTSPAKLMPTT---QSFASDPKYAAPKV---IQAQGKDKEPTK-----------G 932

  Fly  1290 PVSLLVTELAESMN------LPKPPP------------------------------QQQQKL--- 1315
            |..|.:....:.::      ||:.||                              .|..:|
Zfish   933 PCILPIVRDGKKVSNTHYYLLPERPPYLDRYDKFFREAECGEEKKQVNTATVKPMVHQHGELKSN 997

  Fly  1316 --TNGNS--TGSGFKAQLK 1330
              :|.||  |.|||:..||
Zfish   998 FSSNNNSSLTASGFRGGLK 1016

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189	258/1124 (23%)
		PTKc_Abl	382..644	CDD:270645	109/284 (38%)
		FABD	1584..1723	CDD:197885
tnk2b	XP_021336227.1	SAM_TNK-like	32..93	CDD:188938
		PTKc_Ack_like	153..410	CDD:270636	105/258 (41%)
		SH3	416..464	CDD:214620	7/51 (14%)
		GTPase_binding	472..537	CDD:430374	21/141 (15%)
		PHA03247	<609..750	CDD:223021	29/155 (19%)
		Inhibitor_Mig-6	851..927	CDD:463294	26/98 (27%)
		UBA_ACK1	1039..1082	CDD:270460
		UBA_TNK1	1069..1108	CDD:270513