Protein Alignment Abl and ptk2ba

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_005158634.1
• Gene: ptk2ba / 557258
• ZFINID: ZDB-GENE-080207-1
• Length: 933
• Species: Danio rerio
• Alignment Length: 612
• Identity: 165/612 - (26%)
• Similarity: 277/612 - (45%)
• Gaps: 103/612 - (16%)

  Fly   352 EGHGLITPLLYPAPKQNKPT--------VFPLSPEPD-----EWEICRTDIMMKHKLGGGQYGEV 403
            |....:.||  |..|:|..:        ::...||..     ::.|.|.||::...||.|.:|||
Zfish   352 ESRNSLPPL--PGSKENTTSHKEGKNSDIYAEIPEEKPLAACKFSISRNDIVLGRILGEGFFGEV 414

  Fly   404 YEAVWKRYGN---TVAVKTLKEDTMALKD-FLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEF 464
            ::.::|....   .|||||.|:.:..:|: |:.||.|||::.||::|:|||: ..|.|.:|:.|.
Zfish   415 HDGIYKSKSGERVNVAVKTCKDCSADVKEKFMSEALIMKKLDHPHIVRLIGI-IEEDPVWIVMEL 478

  Fly   465 MSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADF 529
            ...|.|.::|:. .:..|..|.|:..:.||:..::|||..|.:|||:|.||.||.....||:.||
Zfish   479 YPFGELENYLKD-NQNKLTNVTLILYSLQISKALAYLEGVNMVHRDIAVRNVLVAKVDCVKLGDF 542

  Fly   530 GLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTD 594
            ||:|.:.::.|...:..:.||||.|||.:.:.:|::.||||.|.|.:|||.:.|..|:..::..|
Zfish   543 GLSRYIEEEEYYKASVTRLPIKWMAPESINFRRFTSASDVWMFAVCMWEIMSGGQQPFFWLENKD 607

  Fly   595 VYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSI------HHALEHMFQESSITEAV 653
            |.::|::|.|:.:|..|||.:|.||.:||.:...|||:|..:      .|.||   ||..:.|..
Zfish   608 VINQLEQGMRLPKPERCPPTLYSLMTRCWSYSPRDRPSFTELVCKLSDVHKLE---QEVEVEELR 669

  Fly   654 EKQLNANATSASSSAPSTSGVATGGGATTT----TAASGC---ASSSSATASLSLTPQMVKKGL- 710
            .:....|.::...:.|..|.:...|..|.:    ..|.|.   :|.:.|.....:..|.|::.|
Zfish   670 ARSRTINISAFPDAPPKPSRMIPPGFNTLSPRLNVQARGVQEPSSKADAQRLWDVERQQVQETLR 734

  Fly   711 --------------PGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTT 761
                          ...:.|.|.|  |:..:.:|:|. ::||..       ||||......|.:.
Zfish   735 RQKQEMLEDHQWLEKEEKLLVPFA--NEDMKTKATTE-NDTGQV-------SSQGPPEKPPRVSA 789

  Fly   762 NKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLST-----NGIHKLKTANYFS---- 817
            .      |||   |:.|..:.|..|:         |.::.:..     |.::.|..:.|.|
Zfish   790 Q------PAP---TAELDRTDDLVYQ---------NVMEMVKVVVQLKNQVNTLPASEYVSVVKS 836

  Fly   818 -----QTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKS 877
                 ::|..:....:|:.| ..|||:       ::..|:::...:.:...:.:..||.......
Zfish   837 VGMTLRSLIHSVDDILPSLH-ESIRTE-------IEGTQKLLNKDLAELISKMRLAQQNSVTSLK 893

  Fly   878 SSCSSFLYDILFRGLARDINSLTQRYD 904
            ..|...:. .....||.|..:|....|
Zfish   894 DECKKQML-AAAHTLAMDSKNLLDAVD 919

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189	3/10 (30%)
		PTKc_Abl	382..644	CDD:270645	102/271 (38%)
		FABD	1584..1723	CDD:197885
ptk2ba	XP_005158634.1	FERM_N_2	20..118	CDD:436229
		B41	33..246	CDD:214604
		FERM_C_FAK1	242..351	CDD:270011
		Protein Kinases, catalytic domain	393..657	CDD:473864	99/265 (37%)
		Focal_AT	796..925	CDD:460992	23/142 (16%)