DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and zap70

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001018425.1 Gene:zap70 / 553615 ZFINID:ZDB-GENE-050522-257 Length:604 Species:Danio rerio


Alignment Length:450 Identity:144/450 - (32%)
Similarity:229/450 - (50%) Gaps:62/450 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   268 EKHSWYHGPISRNAAEYLLSSGI--NGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVF 330
            ||..|:||.|.|...|..|.||.  :|.|||||.:.. |..::|:.|...||||:|..|..||:.
Zfish   159 EKMPWFHGKIPRQEGERRLYSGSQPDGKFLVRERDEM-GTFALSVTYGKTVYHYQILRDKSGKIA 222

  Fly   331 VTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKP----------------TVFPLSPEP 379
            :.:..||:|:.:||.:..:..:  ||:|.|..|...||..                |..|:.|:|
Zfish   223 MPEGTKFDTVWQLVEYLKMKPD--GLVTVLREPCVNQNNAAPAPANAPRRSRGNGYTPPPMVPKP 285

  Fly   380 DEWEICRTDIMMKH------------------------------KLGGGQYGEVYEAVWKRYGN- 413
            ...|..|..:.|.|                              :||.|.:|.|.:.|:|.... 
Zfish   286 MGAEGSRPSLPMDHDGFTSPYDDPNELKKKTLFIKRDKLMIDEVELGSGNFGCVKKGVFKMESKQ 350

  Fly   414 -TVAVKTLK-EDTMALKD-FLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLR 475
             .||:|.|| |:..:::| .:.||.||.::..|.:|::||:|..| ...::.|....|.|..|| 
Zfish   351 IDVAIKVLKNENEKSVRDEMMREAEIMHQLSDPFIVRMIGLCEAE-ALMLVMEMAPAGPLNKFL- 413

  Fly   476 SAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLM--RDD 538
            |..::.:....::.:..|::.||.|||.||::||||||||.|:.:.:..|::||||::.:  .|:
Zfish   414 SGKKDQITTENIVMLMHQVSMGMKYLEGRNFVHRDLAARNVLLVNQQYAKISDFGLSKALGADDN 478

  Fly   539 TYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGY 603
            .|.|..|.|:|:||.|||.:.::|||:|||||:||:.:||..::|..||..:...:|...::.|.
Zfish   479 YYKARTGGKWPLKWYAPECIHFHKFSSKSDVWSFGITMWEAFSFGGKPYKKMKGPEVITYIEGGS 543

  Fly   604 RMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNA-NAT 662
            |::.|..||..:|:||::||.:...:|..|..:...:...:.  ||.:.:...|.. |.|
Zfish   544 RLDCPAACPEAMYELMKECWTYKHEERLNFAKVEEKMRTFYY--SIAKKIPDYLKTENGT 601

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189 37/96 (39%)
PTKc_Abl 382..644 CDD:270645 95/297 (32%)
FABD 1584..1723 CDD:197885
zap70NP_001018425.1 SH2_N-SH2_Zap70_Syk_like 8..111 CDD:198191
SH2_C-SH2_Zap70 152..256 CDD:198265 38/99 (38%)
PTKc_Zap-70 320..588 CDD:270686 92/271 (34%)
Blue background indicates that the domain is not in the aligned region.

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