Protein Alignment Abl and lyn

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_012820235.2
• Gene: lyn / 549989
• XenbaseID: XB-GENE-1015126
• Length: 508
• Species: Xenopus tropicalis
• Alignment Length: 484
• Identity: 204/484 - (42%)
• Similarity: 299/484 - (61%)
• Gaps: 33/484 - (6%)

  Fly   190 RWTSKENLLAPGPE-----EDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHS- 248
            |..|:...|.||.:     |:...:.:|||.:|...::.|:.||||:::::  .:.|||.:|.|
 Frog    39 RPVSRTPSLLPGQKILQEIEEQGNIVIALYPYQGIHQDDLTFKKGEKLKVI--EEHGEWWKAKSL 101

  Fly   249 DSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLR 311
            .:...|::|||||..:|:||...|:...|:|..|| .||:.|.| |:||:||||:|.|..|:|:|
 Frog   102 STKKEGFIPSNYVARVNTLETEEWFFKDITRKDAERQLLAPGNNPGAFLIRESETSKGSYSLSIR 166

  Fly   312 -YEGR----VYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYP--APKQNK 369
             |:.:    :.||:|....:|..:::....|.::.:::.|:.  .:..||...|..|  :||..|
 Frog   167 DYDPKTGDVIKHYKIRTLDNGGYYISPRITFTSICDMIQHYQ--KQADGLCRKLDKPCYSPKPQK 229

  Fly   370 PTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT--VAVKTLKEDTMALKDFLE 432
            |.      :.|.|||.|..|.:..|||.||:|||:...   |.|:  |||||||..||:::.|:|
 Frog   230 PW------DKDAWEIPRESIKLVKKLGAGQFGEVWMGF---YNNSTKVAVKTLKPGTMSVQAFME 285

  Fly   433 EAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASG 497
            ||.:||.::|..||:|..|.::|.|.|||||||:.|:|||||:|.....:....|:..:.|||.|
 Frog   286 EANLMKSLQHDKLVRLYAVVSKEEPIYIITEFMAKGSLLDFLKSDEGAKVILPKLIDFSAQIAEG 350

  Fly   498 MSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNK 562
            |:|:|.:|||||||.|.|.||.::.:.|:|||||||::.|:.|||..||||||||||||.:.:..
 Frog   351 MAYIEKKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGS 415

  Fly   563 FSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDA 627
            |:.|||||:|||||:||.|.|..|||.:..:||...|.:||||.|...||.|:||:|::||:..|
 Frog   416 FTIKSDVWSFGVLLYEIITTGKIPYPGMSNSDVMTALQRGYRMPRMENCPVELYDIMKECWKEKA 480

  Fly   628 TDRPTFKSIHHALEHMFQESSITEAVEKQ 656
            .:||||..:...|:..:   :.|||..:|
 Frog   481 EERPTFDYLQSVLDDFY---TATEAQYQQ 506

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	20/54 (37%)
		SH2_ABL	268..363	CDD:198189	32/101 (32%)
		PTKc_Abl	382..644	CDD:270645	134/263 (51%)
		FABD	1584..1723	CDD:197885
lyn	XP_012820235.2	SH3_Lyn	63..118	CDD:212937	20/56 (36%)
		SH2_Src_Lyn	121..221	CDD:198227	32/101 (32%)
		PTKc_Lyn	235..506	CDD:270657	137/276 (50%)