Protein Alignment Abl and MAP3K20

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_057737.2
• Gene: MAP3K20 / 51776
• HGNCID: 17797
• Length: 800
• Species: Homo sapiens
• Alignment Length: 800
• Identity: 179/800 - (22%)
• Similarity: 280/800 - (35%)
• Gaps: 258/800 - (32%)

  Fly   388 DIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVC 452
            |:......|||.:|.||.|.|......||||.|      || ..:||.|:..:.|.|::|..||.
Human    15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL------LK-IEKEAEILSVLSHRNIIQFYGVI 72

  Fly   453 TREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESR---NYIHRDLAAR 514
            ...|.:.|:||:.|.|:|.|::.|...|.:|...::..||.:|.||.||...   ..|||||.:|
Human    73 LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMDHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSR 137

  Fly   515 NCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEI 579
            |.::..:.::|:.|||.:|.....|:.:..|. ||  |.|||.:.....|...|.:::||:|||:
Human   138 NVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVSETCDTYSYGVVLWEM 199

  Fly   580 ATYGMSPYPAID-LTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHM 643
            .|..: |:..:: |...:..::|..|:..|..||....:|:.|||:.||..||:||.|...||.|
Human   200 LTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263

  Fly   644 FQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKK 708
            ..::|:.:.....|:..|........:...:                  ......||...|.:|:
Human   264 SNDTSLPDKCNSFLHNKAEWRCEIEATLERL------------------KKLERDLSFKEQELKE 310

  Fly   709 G----LPGGQALTPNAHHNDPHQQQASTPMSET---------------------GSTSTKLSTFS 748
            .    ....|.||          :|::||:..:                     |.:|.::|.::
Human   311 RERRLKMWEQKLT----------EQSNTPLLPSFEIGAWTEDDVYCWVQQLVRKGDSSAEMSVYA 365

  Fly   749 SQGKGNVQMRRTTNKQGKQ----APAPPKRTSLLSSS--------------------------RD 783
            |..|.|       |..||:    .....|...::|..                          :|
Human   366 SLFKEN-------NITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHDYINLFHFPPLIKD 423

  Fly   784 S----------------------------------TYREEDPANARCNFIDDLSTN--------- 805
            |                                  .|.|.|.......:|.|::.|
Human   424 SGGEPEENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEIAITYIKDVTFNTNLPDAEIL 488

  Fly   806 --------------GIHKLKTANYFSQTLSRNFKTQIPTHHTHQI---RTQQQQQQQSVQ----- 848
                          ||.|.:|.. .:.|...:.:|...|.|.|.|   ||:.|.:.::||
Human   489 KMTKPPFVMEKWIVGIAKSQTVE-CTVTYESDVRTPKSTKHVHSIQWSRTKPQDEVKAVQLAIQT 552

  Fly   849 ------------------------------------QQQQIVPL---------------SVQQQA 862
                                                |:.|..|:               :...:.
Human   553 LFTNSDGNPGSRSDSSADCQWLDTLRMRQIASNTSLQRSQSNPILGSPFFSHFDGQDSYAAAVRR 617

  Fly   863 HQQQQKQQQYS-IKKSSSCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDATGD------ 920
            .|...|.||.: :.:|.|.|...|     ||.::.:||  ..:|.....:..:||.:.:
Human   618 PQVPIKYQQITPVNQSRSSSPTQY-----GLTKNFSSL--HLNSRDSGFSSGNTDTSSERGRYSD 675

  Fly   921 ---------SLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGL 976
                     |:  ||:.......:.|.|||..|.|...|...|.||   |...|..:|
Human   676 RSRNKYGRGSI--SLNSSPRGRYSGKSQHSTPSRGRYPGKFYRVSQ---SALNPHQSP------- 728

  Fly   977 ETRQSKRSQLHSQAPGPGPP 996
            :.::|.| .||.....||.|
Human   729 DFKRSPR-DLHQPNTIPGMP 747

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	90/259 (35%)
		FABD	1584..1723	CDD:197885
MAP3K20	NP_057737.2	STKc_MLTK	22..263	CDD:270962	89/251 (35%)
		Leucine-zipper	287..308		3/38 (8%)
		SAM_MLTK	338..408	CDD:188928	11/76 (14%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	652..800		25/108 (23%)
		Sensing domain (S). /evidence=ECO:0000269|PubMed:32289254	670..713		9/44 (20%)
		C-terminal domain (CTD). /evidence=ECO:0000269|PubMed:32289254	774..800