DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and TNNI3K

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_057062.1 Gene:TNNI3K / 51086 HGNCID:19661 Length:835 Species:Homo sapiens


Alignment Length:832 Identity:184/832 - (22%)
Similarity:316/832 - (37%) Gaps:213/832 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 CISSSSGVSSAPLGGGSTLRGSRI-------------KSSSSGVASGSGSGG-----GGGGSGSG 85
            |....|.:.:..|.|   ||.||:             |.::..:.|...||.     |.||..:.
Human    77 CGGKKSHIRTLMLKG---LRPSRLTRNGFTALHLAVYKDNAELITSLLHSGADIQQVGYGGLTAL 138

  Fly    86 LSQRSGGHKDARCNPTVGLNIFTEHNGTKH------------SSFRGHPG------KY--HMNLE 130
            ......||.:|       .::..:|....:            :::.||..      |:  .:|:.
Human   139 HIATIAGHLEA-------ADVLLQHGANVNIQDAVFFTPLHIAAYYGHEQVTRLLLKFGADVNVS 196

  Fly   131 ALLQSRPLPHIPAG----STAASLLADAAELQQHQQDS-GGLGLQGSSLGGGHSSTTSVFESAHR 190
            ..:..||| |:.:.    :.|..|:.:.::...:.||: ..:.|...|..|.|.....:.:|.  
Human   197 GEVGDRPL-HLASAKGFLNIAKLLMEEGSKADVNAQDNEDHVPLHFCSRFGHHDIVKYLLQSD-- 258

  Fly   191 WTSKENLLAPGPE----EDDPQLFVALYD---------FQAGGENQLSLKKGEQVRILS------ 236
                   |...|.    ..|..|.:|.|:         .|..|...|:     :..|.|      
Human   259 -------LEVQPHVVNIYGDTPLHLACYNGKFEVAKEIIQISGTESLT-----KENIFSETAFHS 311

  Fly   237 ---YNKSGEWCEAHSDSG--NVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLV 296
               |.||.:..:...|..  |:.....:..|.|:|    :.|||.|  ...::||.:|.:.:.:.
Human   312 ACTYGKSIDLVKFLLDQNVININHQGRDGHTGLHS----ACYHGHI--RLVQFLLDNGADMNLVA 370

  Fly   297 RESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHE--------- 352
            .:...|.|::                 |....:....|...:.:..|:.|:..|.:         
Human   371 CDPSRSSGEK-----------------DEQTCLMWAYEKGHDAIVTLLKHYKRPQDELPCNEYSQ 418

  Fly   353 --GHGLITPLLYPAP--------KQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAV 407
              |.|....:  |:|        |:....:...:..|..:.:..::|.....:|.|.:|:||:. 
Human   419 PGGDGSYVSV--PSPLGKIKSMTKEKADILLLRAGLPSHFHLQLSEIEFHEIIGSGSFGKVYKG- 480

  Fly   408 WKRYGNTVAVKTLKEDTMALKD----FLEEAAIMKEMKHPNLVQLIGVCTREP-PFYIITEFMSH 467
             :.....||:|..:.:|...|.    |..|.:|:.::.||.::|.:|.|..:| .|.|:|:::|.
Human   481 -RCRNKIVAIKRYRANTYCSKSDVDMFCREVSILCQLNHPCVIQFVGACLNDPSQFAIVTQYISG 544

  Fly   468 GNLLDFLRSAGRETLDAVALLYMATQIASGMSYLE--SRNYIHRDLAARNCLVGDNKLVKVADFG 530
            |:|...|....| .||..:.|.:|..:|.||.||.  ::..|||||.:.|.|:.::....|||||
Human   545 GSLFSLLHEQKR-ILDLQSKLIIAVDVAKGMEYLHNLTQPIIHRDLNSHNILLYEDGHAVVADFG 608

  Fly   531 LARLMR---DDTYTAHAGAKFPIKWTAPEGLAY-NKFSTKSDVWAFGVLLWEIATYGMSPY---- 587
            .:|.::   :|..|...|   .::|.|||.... .:::.|:||:::.:.||||.| |..|:    
Human   609 ESRFLQSLDEDNMTKQPG---NLRWMAPEVFTQCTRYTIKADVFSYALCLWEILT-GEIPFAHLK 669

  Fly   588 PAIDLTDV-YHKLDKGYRMERPP---GCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESS 648
            ||....|: ||.:       |||   ..|..:..|:.:.|......||.|..:...||.....  
Human   670 PAAAAADMAYHHI-------RPPIGYSIPKPISSLLIRGWNACPEGRPEFSEVVMKLEECLCN-- 725

  Fly   649 ITEAVEKQLNANATSASSSAPSTSG---VATGGGATTTTAA--------------SGCASSSSA- 695
                :|....|::.|:.|.:||:|.   |..||...:..||              |..|.|.|| 
Human   726 ----IELMSPASSNSSGSLSPSSSSDCLVNRGGPGRSHVAALRSRFELEYALNARSYAALSQSAG 786

  Fly   696 -TASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLST 746
             .:|..|:.:.:|:.|                   ..||:.:.|..|..:|:
Human   787 QYSSQGLSLEEMKRSL-------------------QYTPIDKYGYVSDPMSS 819

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 13/73 (18%)
SH2_ABL 268..363 CDD:198189 16/105 (15%)
PTKc_Abl 382..644 CDD:270645 83/280 (30%)
FABD 1584..1723 CDD:197885
TNNI3KNP_057062.1 ANKYR 54..290 CDD:440430 42/232 (18%)
ANK repeat 66..98 CDD:293786 8/23 (35%)
ANK 1 66..96 6/21 (29%)
ANK repeat 100..131 CDD:293786 4/30 (13%)
ANK 2 100..129 4/28 (14%)
ANK 3 133..162 6/35 (17%)
ANK repeat 134..164 CDD:293786 5/36 (14%)
ANK repeat 166..197 CDD:293786 4/30 (13%)
ANK 4 166..195 3/28 (11%)
ANK repeat 199..232 CDD:293786 6/33 (18%)
ANK 5 199..228 6/29 (21%)
ANK 6 234..263 6/37 (16%)
ANK repeat 234..262 CDD:293786 6/36 (17%)
ANK repeat 269..302 CDD:293786 7/37 (19%)
ANK 7 269..298 6/28 (21%)
ANK repeat 304..337 CDD:293786 6/32 (19%)
ANK 8 304..335 6/30 (20%)
Ank_2 309..401 CDD:463710 19/114 (17%)
ANK repeat 339..369 CDD:293786 10/35 (29%)
ANK 9 339..368 10/34 (29%)
ANK 10 381..410 5/28 (18%)
PKc_TNNI3K 469..722 CDD:270966 82/266 (31%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..751 6/18 (33%)
Blue background indicates that the domain is not in the aligned region.

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