DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and grb2a

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001007770.1 Gene:grb2a / 493609 ZFINID:ZDB-GENE-041121-1 Length:217 Species:Danio rerio


Alignment Length:138 Identity:51/138 - (36%)
Similarity:86/138 - (62%) Gaps:7/138 - (5%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHG 275
            :|.|||:|..:::||.|:||.:::|:......|.:|.. :|..|::|.||:    .::.|.|::|
Zfish     4 IAKYDFKATADDELSFKRGEILKVLNEECDQNWYKAEL-NGKEGFIPKNYI----EMKPHPWFYG 63

  Fly   276 PISRNAAEYLLS-SGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNT 339
            .|.|..||.:|: ...:|:||:|||||:||..|:|:::...|.|:::..|..||.|: ...|||:
Zfish    64 KIPRAKAEEMLNKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL-WVVKFNS 127

  Fly   340 LAELVHHH 347
            |..||.:|
Zfish   128 LNSLVDYH 135

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 18/51 (35%)
SH2_ABL 268..363 CDD:198189 33/81 (41%)
PTKc_Abl 382..644 CDD:270645
FABD 1584..1723 CDD:197885
grb2aNP_001007770.1 SH3_GRB2_N 1..56 CDD:212879 18/56 (32%)
SH2_Grb2_like 56..150 CDD:199828 33/81 (41%)
SH3_GRB2_C 160..212 CDD:212882
Blue background indicates that the domain is not in the aligned region.

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