DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and grb2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001008130.1 Gene:grb2 / 493492 XenbaseID:XB-GENE-6070000 Length:229 Species:Xenopus tropicalis


Alignment Length:190 Identity:62/190 - (32%)
Similarity:97/190 - (51%) Gaps:29/190 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHG 275
            ||.|||:|..:::||.|:|:.:::|:......|.:|.. :|..|::|.||:    .::.|.|:.|
 Frog     4 VAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAEL-NGKDGFIPKNYI----EMKPHPWFFG 63

  Fly   276 PISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNT 339
            .|.|..||.:| ....:|:||:|||||:||..|:|:::...|.|:::..|..||.|: ...|||:
 Frog    64 KIPRAKAEEMLGKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFL-WVVKFNS 127

  Fly   340 LAELVHHH-----------------SVP--HEGHGLITPLLYPAPKQNKPTVFPLSPEPD 380
            |.|||.:|                 .||  |.|......|..|...|   .:|...|:.|
 Frog   128 LNELVDYHRSTSVSRNQQIFLRDIEQVPQVHGGDRATNLLQQPTYVQ---ALFDFDPQED 184

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 18/51 (35%)
SH2_ABL 268..363 CDD:198189 39/114 (34%)
PTKc_Abl 382..644 CDD:270645
FABD 1584..1723 CDD:197885
grb2NP_001008130.1 SH3_GRB2_N 1..56 CDD:212879 18/56 (32%)
SH2_Grb2_like 56..150 CDD:199828 34/94 (36%)
SH3_GRB2_C 172..224 CDD:212882 4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

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