DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and NCK1

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_006144.1 Gene:NCK1 / 4690 HGNCID:7664 Length:377 Species:Homo sapiens


Alignment Length:162 Identity:53/162 - (32%)
Similarity:86/162 - (53%) Gaps:28/162 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 ALYDFQAGGENQLSLKKGEQVRILSYNKSG-EWCEAHSDSGNVGWVPSNYVT-----PLNS-LEK 269
            |||.|.:..:.:|:.:||:.:.::...::. ||.:....:|.||.||.||||     ||.| ||.
Human   197 ALYPFSSSNDEELNFEKGDVMDVIEKPENDPEWWKCRKINGMVGLVPKNYVTVMQNNPLTSGLEP 261

  Fly   270 ------------------HSWYHGPISRNAAEYLLSS-GINGSFLVRESESSPGQRSISLRYEGR 315
                              :.||:|.::|:.||..|:. |..|.||:|:|||||...|:||:.:|:
Human   262 SPPQCDYIRPSLTGKFAGNPWYYGKVTRHQAEMALNERGHEGDFLIRDSESSPNDFSVSLKAQGK 326

  Fly   316 VYHYRISEDPDGKVFVTQEAKFNTLAELVHHH 347
            ..|:::....  .|:...:.||:|:.|||.|:
Human   327 NKHFKVQLKE--TVYCIGQRKFSTMEELVEHY 356

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 18/56 (32%)
SH2_ABL 268..363 CDD:198189 31/99 (31%)
PTKc_Abl 382..644 CDD:270645
FABD 1584..1723 CDD:197885
NCK1NP_006144.1 SH3_Nck1_1 3..61 CDD:212833
SH3_Nck1_2 108..162 CDD:212834
SH3_Nck1_3 193..249 CDD:212837 17/51 (33%)
SH2_Nck1 280..376 CDD:198271 30/79 (38%)
Blue background indicates that the domain is not in the aligned region.

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