DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Shark

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_524743.2 Gene:Shark / 44353 FlyBaseID:FBgn0015295 Length:939 Species:Drosophila melanogaster


Alignment Length:734 Identity:163/734 - (22%)
Similarity:253/734 - (34%) Gaps:266/734 - (36%)


- Green bases have known domain annotations that are detailed below.


  Fly   121 HPGKYHMNLEA-----LLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSS 180
            |....|.||||     |.::.|||...:|.....|..:|.:                        
  Fly   226 HEAAKHGNLEAVQELLLAEAPPLPRTSSGEFPFDLAKEAGQ------------------------ 266

  Fly   181 TTSVFE------------SAHRW-----TSKE----------NLLAPGPEEDDPQLFVALYD--- 215
             |:|.|            :..:|     |.:|          .|||..||.|....|:..|.   
  Fly   267 -TAVEEFLLNYKLPPANTTRDQWYHGTLTREEAVAILKKHAKELLAKQPEVDTSGCFLVRYSESP 330

  Fly   216 -------------------------------FQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSD 249
                                           .|:||...|.:..|      .|..|.|...||..
  Fly   331 AASGLVLTLLCDQVVKNFRISQADLYQNGNKVQSGGSKFLYIDDG------PYWPSVEHLIAHFM 389

  Fly   250 SGNVGW---------------VPS--------------NYVTPLNSLEKHSWYHGP--------- 276
            ..:.|.               |||              :..||...:..||.:..|         
  Fly   390 RFSYGLPVSLKYPVPPQPKPEVPSFATIPRSNMKPKAASPATPPTPVSPHSHHQHPHVPALTITK 454

  Fly   277 ----------------------------ISRNAAEYLLS---SGINGSFLVRESE---SSPGQRS 307
                                        :.:|.::...|   |.::||....|.|   ::|..:|
  Fly   455 KKQKENSSSMFNTLRLTSPKKALFDMNSLRKNKSKGKRSDSESSVSGSLAGTEQELQAAAPMLKS 519

  Fly   308 ISLRYE-----------------GRVYHYRISEDP------------------------------ 325
            :|...|                 |.||:...:..|                              
  Fly   520 LSFSTEFSTFNADGVTGSGAAAAGEVYNVPRNNTPIEIDLPPIAQKTEAEVEYFTKSDVAIERER 584

  Fly   326 -------------------DGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPT 371
                               |.::.....|:.|:|            |....|.....:....|.:
  Fly   585 AGQWIGNGYQPTMDVLSLLDQQIKAPAVARLNSL------------GPNASTESEMASYLHRKCS 637

  Fly   372 VFPLSPEPDEWEICR-------TDIMMKHKLGGGQYGEVYEAVW--KRYGN------TVAVKTLK 421
            ..|.:|...|.|..:       ..:::..::|.|::|.|:.. |  ::.|.      .||:|.|.
  Fly   638 GTPSTPSATEVEAAKLRFFIEPEKLVLDREIGHGEFGSVHSG-WLLRKSGAGEESRLEVAIKMLS 701

  Fly   422 EDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVA 486
            ::....::||.||::|..::|..:|:|||:...| ...::.|....|::|.::...|.|......
  Fly   702 DEHSNKQEFLREASVMMRLEHKCIVRLIGIAKGE-MLMMVQELAPLGSMLQYILDHGHEITANAE 765

  Fly   487 LLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDT--YTAHAGAKFP 549
            |...|:|||.||.||||::::||||||||.|:......|::|||::|.:|..:  |....|.::|
  Fly   766 LKVWASQIACGMHYLESQHFVHRDLAARNILLTARHQAKISDFGMSRSLRPGSTEYQFTQGGRWP 830

  Fly   550 IKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPE 614
            |:|.|||......||..||||:|||.:||:.:.|..||..|...|....:|.|.|:.:|..||..
  Fly   831 IRWYAPESFNLGIFSHASDVWSFGVTIWEMFSLGAPPYGEISNVDAIKLVDSGERLPQPNLCPAY 895

  Fly   615 VYDLMRQCWQWDATDRPTF 633
            :|.:|:.||:....|||||
  Fly   896 IYAVMQSCWKERPKDRPTF 914

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 16/116 (14%)
SH2_ABL 268..363 CDD:198189 24/203 (12%)
PTKc_Abl 382..644 CDD:270645 92/269 (34%)
FABD 1584..1723 CDD:197885
SharkNP_524743.2 SH2_Nterm_shark_like 8..91 CDD:198210
ANKYR <94..317 CDD:440430 24/115 (21%)
ANK repeat 124..151 CDD:293786
ANK repeat 153..184 CDD:293786
ANK repeat 186..217 CDD:293786
ANK repeat 220..245 CDD:293786 7/18 (39%)
SH2_Cterm_shark_like 287..395 CDD:198211 21/113 (19%)
PTKc_Syk_like 666..926 CDD:270650 91/251 (36%)
Blue background indicates that the domain is not in the aligned region.

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