Protein Alignment Abl and MAP3K9

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_011535090.1
• Gene: MAP3K9 / 4293
• HGNCID: 6861
• Length: 1166
• Species: Homo sapiens
• Alignment Length: 1591
• Identity: 321/1591 - (20%)
• Similarity: 507/1591 - (31%)
• Gaps: 614/1591 - (38%)

  Fly   151 LADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEE---DDP-QLFV 211
            ||.||......:|..|.|.:                 ......:|...|.||.|   |.| ..:.
Human    11 LASAAAAAPPGEDGAGAGAE-----------------EEEEEEEEAAAAVGPGELGCDAPLPYWT 58

  Fly   212 ALYDFQAGGENQLSLKKGEQVRILSYNK--SGE--WCEAHSDSGNVGWVPSNYVTPLNSLEKHSW 272
            |:::::|.||::|:|:.|:.|.:||.:.  ||:  |.....:. .||..|||||||.::.
Human    59 AVFEYEAAGEDELTLRLGDVVEVLSKDSQVSGDEGWWTGQLNQ-RVGIFPSNYVTPRSAF----- 117

  Fly   273 YHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKF 337
                                     .|...||                 .|||.
Human   118 -------------------------SSRCQPG-----------------GEDPS----------- 129

  Fly   338 NTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGE 402
                                   .||          |:    ...||...::.::..:|.|.:|:
Human   130 -----------------------CYP----------PI----QLLEIDFAELTLEEIIGIGGFGK 157

  Fly   403 VYEAVWKRYGNTVAVKTLKED-----TMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIIT 462
            ||.|.|  .|:.||||..:.|     :..:::..:||.:...:||||::.|.|||.:||...::.
Human   158 VYRAFW--IGDEVAVKAARHDPDEDISQTIENVRQEAKLFAMLKHPNIIALRGVCLKEPNLCLVM 220

  Fly   463 EFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESR---NYIHRDLAARNCLV------ 518
            || :.|..|:.:.|..|...|  .|:..|.|||.||:||...   ..|||||.:.|.|:
Human   221 EF-ARGGPLNRVLSGKRIPPD--ILVNWAVQIARGMNYLHDEAIVPIIHRDLKSSNILILQKVEN 282

  Fly   519 GD--NKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIAT 581
            ||  ||::|:.||||||.....|..:.||.   ..|.|||.:..:.||..||||::||||||:.|
Human   283 GDLSNKILKITDFGLAREWHRTTKMSAAGT---YAWMAPEVIRASMFSKGSDVWSYGVLLWELLT 344

  Fly   582 YGMSPYPAID-LTDVYHKLDKGYRMER-----PPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL 640
             |..|:..|| |...|     |..|.:     |..||.....||..||..|...||:|.:|...|
Human   345 -GEVPFRGIDGLAVAY-----GVAMNKLALPIPSTCPEPFAKLMEDCWNPDPHSRPSFTNILDQL 403

  Fly   641 EHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQM 705
                                                     ||...||..             :|
Human   404 -----------------------------------------TTIEESGFF-------------EM 414

  Fly   706 VKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPA 770
            .|...   ..|..|..|      :......:..:...:|.|:..      ::.|...:|..|...
Human   415 PKDSF---HCLQDNWKH------EIQEMFDQLRAKEKELRTWEE------ELTRAALQQKNQEEL 464

  Fly   771 PPKRTSLLSSSRDSTYREEDPANARCNFIDDLSTNGIHKL--------KTANYFSQT---LSRNF 824
            ..:|...|:.      ||.|......|.|       ||:|        |....|.::   |....
Human   465 LRRREQELAE------REIDILERELNII-------IHQLCQEKPRVKKRKGKFRKSRLKLKDGN 516

  Fly   825 KTQIPTHHTHQIRTQQQ----------QQQQSVQQQQQIVP--LSVQQQAHQQ----QQKQQQYS 873
            :..:|:...|:...|..          ..:.|......|:|  .::|.:...|    |..|...|
Human   517 RISLPSDFQHKFTVQASPTMDKRKSLINSRSSPPASPTIIPRLRAIQCETVSQISWGQNTQGHLS 581

  Fly   874 IKKSS-----SCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQVIAAP 933
            ...||     :||...:..|...:...::.||....|:|
Human   582 PALSSHRLVQACSIHNFCHLSSTMCIYMHILTPGESSKT-------------------------- 620

  Fly   934 VTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPT------GTPVMGNRGLETRQSKRSQLHSQAPG 992
                        .|...:.|:...:....:.|.      |...:|.:.|.:......|...:|.|
Human   621 ------------WGRSSVVPKEEGEEEEKRAPKKKGRTWGPGTLGQKELASGDEGSPQRREKANG 673

  Fly   993 PGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPAL 1057
            ...||..||.         |         :.:|.:|:.|                :..|.:||.|
Human   674 LSTPSESPHF---------H---------LGLKSLVDGY----------------KQWSSSAPNL 704

  Fly  1058 ---PATAPSLPPANGHATPPAARLNPKASPIPPQQMIRSNSSGGVTMQNNAAASLNKLQRHRTTT 1119
               |.::|:||                                |.|
Human   705 VKGPRSSPALP--------------------------------GFT------------------- 718

  Fly  1120 EGTMMTFSSFRAGGSSSSPKRSASGVASGVQPALANLEFPPPPLDLPPPPEEFEGGPPPPPPAPE 1184
              ::|..:..           :||.|.               |:|: ...|:.||     |.:.|
Human   719 --SLMEMALL-----------AASWVV---------------PIDI-EEDEDSEG-----PGSGE 749

  Fly  1185 SAVQ--AIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVS--NIAPSVEEAS-----SRFGVSLRK 1240
            |.:|  ..|.:|....|..   .:|:|. ::|..|.:.:  |.|.|..:.:     .|.|...|:
Human   750 SRLQHSPSQSYLCIPFPRG---EDGDGP-SSDGIHEEPTPVNSATSTPQLTPTNSLKRGGAHHRR 810

  Fly  1241 REPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPASHLANGSGIAVVDPVSLLVTELAESMNLP 1305
            .|.:...|.::.:                          |.|.|..:::.....:..|.|    |
Human   811 CEVALLGCGAVLA--------------------------ATGLGFDLLEAGKCQLLPLEE----P 845

  Fly  1306 KPPPQQQQKLTNGNSTGSGFKAQLKKVEPKKMSAPMPKAEPANTIIDFKAHLRRVDKEKEP---- 1366
            :||.::::|...|....|.        .|::.::|     |:          |::.|::||
Human   846 EPPAREEKKRREGLFQRSS--------RPRRSTSP-----PS----------RKLFKKEEPMLLL 887

  Fly  1367 ATPAPAPATVAVANNANCNTTGTLNRKEDGSKKFSQAMQKTEIKI-DVTNSNVEADAGAAGEGDL 1430
            ..|:.:...:::::.:.||:|.:|.|.:           ..||.: ::..|.|||.       .|
Human   888 GDPSASLTLLSLSSISECNSTRSLLRSD-----------SDEIVVYEMPVSPVEAP-------PL 934

  Fly  1431 GKRRSTGSINSLKKLWEQQPP---APDYATSTILQQ-------------QPSVVNGGGTPNAQ-L 1478
            ........:|...:.:::.|.   .|.:.|.|...|             :|..:....:|::. |
Human   935 SPCTHNPLVNVRVERFKRDPNQSLTPTHVTLTTPSQPSSHRRTPSDGALKPETLLASRSPSSNGL 999

  Fly  1479 SPKYGMKSGAINTVGTLPAKLGNKQP---PAAP------PPPPPNCTTSNSSTTS---------- 1524
            ||..|        .|.|.....::.|   |..|      ||.|....|...||..
Human  1000 SPSPG--------AGMLKTPSPSRDPGEFPRLPDPNVVFPPTPRRWNTQQDSTLERPKTLEFLPR 1056

  Fly  1525 ---------------ISTSSRDCTSRQQASSTIKTSHSTQLFTDDEEQSHTEGLGSGGQGSADMT 1574
                           :|.|....||...:|||...|:....|..                    :
Human  1057 PRPSANRQRLDPWWFVSPSHARSTSPANSSSTETPSNLDSCFAS--------------------S 1101

  Fly  1575 QSLYEQKPQIQQKPAV------PHKPTKLTI 1599
            .|..|::|.:   ||:      |..||:.|:
Human  1102 SSTVEERPGL---PALLPFQAGPLPPTERTL 1129

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	20/57 (35%)
		SH2_ABL	268..363	CDD:198189	6/94 (6%)
		PTKc_Abl	382..644	CDD:270645	102/283 (36%)
		FABD	1584..1723	CDD:197885	6/22 (27%)
MAP3K9	XP_011535090.1	SH3_MLK1-3	56..113	CDD:212992	20/57 (35%)
		STKc_MLK1	137..406	CDD:271047	103/323 (32%)