DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and Csk

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_001262476.1	Gene:	Csk / 41398	FlyBaseID:	FBgn0262081	Length:	1052	Species:	Drosophila melanogaster

Alignment Length:	718	Identity:	223/718 - (31%)
Similarity:	332/718 - (46%)	Gaps:	131/718 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 GAHSGGGGSGAPVSCIGLSSSPVASVSPHCISSS----------SGVSSAPLGGGSTLRGSRIKS 64
            ||.|.|...|:.|..:.|....::...||.:..|          :.|.....|..:.|..|....
  Fly   402 GAGSSGTAPGSAVGAVLLHQQQLSQSQPHIVPPSIPPHHHHHRENNVHPIQAGAAAALHLSSHAL 466

  Fly    65 SSSGVASGSGSGGGGGGSGSGLSQRSGGHKDARCNPTVGLNIFTEHNGTKHSSFRGHPGKYHMNL 129
            :|..:.|.:.:......|.:...|::...:..:           :.....||
  Fly   467 NSHNLISSASNHSPKSPSQTQQQQQTTNQQQQQ-----------QQQQASHS------------- 507

  Fly   130 EALLQSRPLPHI----PAG--STAASLLADAAELQQHQQD---------SGGLGLQGSSLG---- 175
             .|....|.|.:    |||  |.|.:..|.||..||.||.         .||.||..|||.
  Fly   508 -ILSTFAPAPTVAAVQPAGSQSVAGTAAAVAAVAQQQQQQHLQLLANCPPGGAGLMSSSLNAAQM 571

  Fly   176 GGHSS-------TTSVFESAHRWTSKENLL---AP-GPEEDDPQLFV------------ALYDFQ 217
            |.|.:       :.::..|.|    ..|:|   || .|:...|...|            :|:.|.
  Fly   572 GMHGAERALPPKSLALSGSQH----GSNMLLHTAPQPPQASQPAAVVGVSGSGSAGMSTSLHSFD 632

  Fly   218 AGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTP----------LNSLEKHSW 272
            ..|     :..|..|     |.|..|....:.:.|...:....:.|          ||::   .|
  Fly   633 ING-----VTAGSGV-----NASSAWSSGSTTAMNHASLSPTALAPQQGRSRCEVKLNAM---PW 684

  Fly   273 YHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKF 337
            :||.|:|:.||:||....:|.||||||.:.||..::.:.::.:|.|||: :..:.|:.:..|..|
  Fly   685 FHGSITRDEAEHLLQPREDGLFLVRESTNFPGDYTLCVCFQSKVEHYRV-KYLENKLTIDDEEYF 748

  Fly   338 NTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPE--PDEWEICRTDIMMKHKLGGGQY 400
            ..|.:||.|:..  :..||.|.|:...||..|......|.:  ...|.|...::.::..:|.|::
  Fly   749 ENLGQLVAHYEA--DADGLCTQLIKCLPKLGKQEFCINSKDFVDKGWVIPEAELQLRESIGKGEF 811

  Fly   401 GEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFM 465
            |:|...:.:  ...||||.|| |..|::.||.||::|..::|.|||:.||:.......|::||:|
  Fly   812 GDVMLGILR--NEKVAVKMLK-DEGAVQKFLAEASVMTTLEHDNLVKFIGLVFTSKHLYLVTEYM 873

  Fly   466 SHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFG 530
            |.|:|:|:|||.||:.:.....:..|...||||.|||::..:||||||||.|:.::.:.||:|||
  Fly   874 SKGSLVDYLRSRGRQHITKKDQIIFAYDTASGMEYLEAKKVVHRDLAARNVLISEDCVAKVSDFG 938

  Fly   531 LARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDV 595
            ||   |::.|....| |.||||||||.|...:||.|||:|:||:|||||.::|..|||.|.|.||
  Fly   939 LA---REECYNLDVG-KLPIKWTAPEALKNGRFSNKSDMWSFGILLWEIYSFGRVPYPRIPLADV 999

  Fly   596 YHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNAN 660
            ...::.||:||.|.|||||:|::|||.|..:...||||..:               .|:.||..|
  Fly  1000 VKHVEVGYKMEAPEGCPPEIYEMMRQAWDLNPAKRPTFAEL---------------KVKLQLLNN 1049

  Fly   661 ATS 663
            ||:
  Fly  1050 ATA 1052

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	10/65 (15%)
		SH2_ABL	268..363	CDD:198189	33/94 (35%)
		PTKc_Abl	382..644	CDD:270645	115/261 (44%)
		Pkinase_Tyr	389..640	CDD:285015	113/250 (45%)
		FABD	1584..1723	CDD:197885
Csk	NP_001262476.1	SH2_csk_like	680..777	CDD:198190	36/102 (35%)
		PTKc_Csk_like	793..1047	CDD:270635	117/275 (43%)
		STYKc	800..1044	CDD:214568	114/265 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468360
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950