DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and LYN

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_002341.1 Gene:LYN / 4067 HGNCID:6735 Length:512 Species:Homo sapiens


Alignment Length:484 Identity:207/484 - (42%)
Similarity:290/484 - (59%) Gaps:42/484 - (8%)


- Green bases have known domain annotations that are detailed below.


  Fly   195 ENLLAPG-------PEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHS-DSG 251
            |:.|.||       |||.. .:.||||.:.....:.||.||||::::|  .:.|||.:|.| .:.
Human    47 ESQLLPGQRFQTKDPEEQG-DIVVALYPYDGIHPDDLSFKKGEKMKVL--EEHGEWWKAKSLLTK 108

  Fly   252 NVGWVPSNYVTPLNSLEKHSWYHGPISRNAAE-YLLSSGIN-GSFLVRESESSPGQRSISLR--- 311
            ..|::|||||..||:||...|:...|:|..|| .||:.|.: |:||:||||:..|..|:|:|   
Human   109 KEGFIPSNYVAKLNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDFD 173

  Fly   312 --YEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPL--LYPAPKQNKPTV 372
              :...:.||:|....:|..:::....|..:::::.|:.  .:..||...|  ...:||..||. 
Human   174 PVHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQ--KQADGLCRRLEKACISPKPQKPW- 235

  Fly   373 FPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT---VAVKTLKEDTMALKDFLEEA 434
                 :.|.|||.|..|.:..:||.||:||    ||..|.|.   |||||||..||:::.|||||
Human   236 -----DKDAWEIPRESIKLVKRLGAGQFGE----VWMGYYNNSTKVAVKTLKPGTMSVQAFLEEA 291

  Fly   435 AIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRS--AGRETLDAVALLYMATQIASG 497
            .:||.::|..||:|..|.|||.|.|||||:|:.|:|||||:|  .|:..|.  .|:..:.|||.|
Human   292 NLMKTLQHDKLVRLYAVVTREEPIYIITEYMAKGSLLDFLKSDEGGKVLLP--KLIDFSAQIAEG 354

  Fly   498 MSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNK 562
            |:|:|.:|||||||.|.|.||.::.:.|:|||||||::.|:.|||..||||||||||||.:.:..
Human   355 MAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGC 419

  Fly   563 FSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDA 627
            |:.|||||:||:||:||.|||..|||.....||...|.:||||.|...||.|:||:|:.||:..|
Human   420 FTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMTALSQGYRMPRVENCPDELYDIMKMCWKEKA 484

  Fly   628 TDRPTFKSIHHALEHMFQESSITEAVEKQ 656
            .:||||..:...|:..:   :.||...:|
Human   485 EERPTFDYLQSVLDDFY---TATEGQYQQ 510

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 22/54 (41%)
SH2_ABL 268..363 CDD:198189 29/103 (28%)
PTKc_Abl 382..644 CDD:270645 138/266 (52%)
FABD 1584..1723 CDD:197885
LYNNP_002341.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..62 4/14 (29%)
SH3_Lyn 67..122 CDD:212937 22/56 (39%)
SH2_Src_Lyn 125..225 CDD:198227 29/101 (29%)
PTKc_Lyn 239..510 CDD:270657 140/279 (50%)
Blue background indicates that the domain is not in the aligned region.

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