Protein Alignment Abl and map3k12

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_996977.2
• Gene: map3k12 / 404626
• ZFINID: ZDB-GENE-040426-2436
• Length: 897
• Species: Danio rerio
• Alignment Length: 1092
• Identity: 227/1092 - (20%)
• Similarity: 381/1092 - (34%)
• Gaps: 341/1092 - (31%)

  Fly   234 ILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRE 298
            :||.:..|.....||:|..:...|:|:...:..|::.....|.:...|..:.|..| .|.||
Zfish    52 VLSIDPVGGGSGTHSNSPTLSDEPTNFSNSVLKLQEGGAEGGAVRSQADSFRLQPG-GGGFL--- 112

  Fly   299 SESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYP 363
                          ||.....:......||.:.|:.
Zfish   113 --------------EGLFGCLKPVWTMIGKAYSTEH----------------------------- 134

  Fly   364 APKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALK 428
              ||:         :.:.||:...:|.....:|.|..|.|:  :.|.:|..||||.:::
Zfish   135 --KQS---------QEECWEVPFEEISELQWVGSGAQGAVF--LGKFHGEEVAVKKVRD------ 180

  Fly   429 DFLEEAAI--MKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMA 491
              ::|..|  ::::||||::...||||:.|.:.|:.|:.:.|.|.:.|| |||: :....|:..|
Zfish   181 --IKETEIKHLRKLKHPNIITFKGVCTQAPCYCILMEYCAQGQLYEVLR-AGRK-ITPCLLVDWA 241

  Fly   492 TQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRD-DTYTAHAGAKFPIKWTAP 555
            ..||.||:||.....|||||.:.|.|:..:.|||::|||.::.:|| .|..:.||.   :.|.||
Zfish   242 MGIAGGMNYLHLHKIIHRDLKSPNMLITHDDLVKISDFGTSKELRDKSTKMSFAGT---VAWMAP 303

  Fly   556 EGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKL-DKGYRMERPPGCPPEVYDLM 619
            |.:.....|.|.|:|:|||:|||:.| |..||..:|.:.:...: :...::..|..||.....|:
Zfish   304 EVIRNEPVSEKVDIWSFGVVLWEMLT-GEIPYKDVDSSAIIWGVGNNSLQLPLPDSCPDGFKILL 367

  Fly   620 RQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTT 684
            ||||.....:||:|:.|   |.|:
Zfish   368 RQCWNCKPRNRPSFRQI---LLHL----------------------------------------- 388

  Fly   685 AASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSS 749
                    ..|:|.:..|||                               ||        .|.|
Zfish   389 --------DIASADVLSTPQ-------------------------------ET--------YFKS 406

  Fly   750 QGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYR-EEDPANARCNFIDDLSTNGIHKLKTA 813
            |.:...::::...|              :.|.....:| :|:..|.|   .::|.    |.|...
Zfish   407 QAEWREEVKQHFEK--------------IKSEGTCLHRLDEELINRR---REELR----HALDIR 450

  Fly   814 NYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSS 878
            .::.:.|.|                     ..::..:...|.|.::.:..:..:::|
Zfish   451 EHYERKLER---------------------ANNLYMELNAVMLQLELKEKELLRREQ-------- 486

  Fly   879 SCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDATGD---------SLEQSLSQVIAAPV 934
             |....|..||:  ....|::.:.....:.|...|......|         .::..:.||...|.
Zfish   487 -CLDKKYPGLFK--HHTSNTVDKLIKKRSAPQKLPPHGKRPDLLRSEIILPKMDAGVLQVTVPPC 548

  Fly   935 TNKMQHS---------LHSGGGGGGIGPRSSQQHSSFKR-----------PTGTPVMGN-RGLET 978
            :|:...|         .|..||.|..|..|..:|.|...           |...|:..: .|...
Zfish   549 SNRGSTSPSRARRVKTRHRRGGRGSSGDLSGPKHPSAPASREREPVANTPPPAAPIAESVSGSTM 613

  Fly   979 RQSKRS----QLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPK-GA 1038
            |:.:..    :|.|.:|.....:.:...|.:||.|   |.|:|. |              |: ||
Zfish   614 REGQLEPPPLKLSSSSPDLLSSTRRVEDGVSGVAT---PETLGR-D--------------PRGGA 660

  Fly  1039 RIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARLNPKASPIPPQQMIRSNSSGGVTMQN 1103
            ..||.||.....|:.|   ...|.|||.::...:|...|......   ||...|....|.|.:..
Zfish   661 EAGAGLDETPPRSDTA---SEDAASLPFSSSPDSPCCGRSGAVGR---PQAEEREEGPGAVRLPR 719

  Fly  1104 NAAASLNKLQRHRTTTEGTMMTFSS--FRAGGSSSSPKRSASGVASGVQPALANLEFPPPPLDLP 1166
            .::              |:.:|.|:  :||    :..::...||:|
Zfish   720 GSS--------------GSHLTPSAILYRA----AITRKQRRGVSS------------------- 747

  Fly  1167 PPPEEFEGGPP-----PPPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVSNIAPS 1226
               ||.||...     |....|.|..:.  |.:......|.::|.|...:..|.||:...::..:
Zfish   748 ---EEEEGEVDSEVELPRRRRPTSITKC--QSVSTFSSENLSVSEGEEGHTTDHSHSGTPDVVST 807

  Fly  1227 VEEASSRFGVSLRKREPSTDSCSSLGSP-PEDLKEKLITEIKAAGKDTAPAS 1277
            ..:         .:.:..:|...|.||. |.|:.:..::|.:||..:...|:
Zfish   808 NTD---------ERLDDRSDDLISQGSEIPVDITDPTLSEREAAALEQERAN 850

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	8/28 (29%)
		SH2_ABL	268..363	CDD:198189	12/94 (13%)
		PTKc_Abl	382..644	CDD:270645	92/265 (35%)
		FABD	1584..1723	CDD:197885
map3k12	NP_996977.2	None