DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and btl

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_729956.1 Gene:btl / 39564 FlyBaseID:FBgn0285896 Length:1052 Species:Drosophila melanogaster


Alignment Length:535 Identity:170/535 - (31%)
Similarity:241/535 - (45%) Gaps:134/535 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   232 VRILSYNKSGEW--CEAHSDSGNVGWVPSN------YVTPLNSLEKHSWYHG-PISRNAAE---- 283
            :|.:::::.| |  |.|.|..|.     ||      .|:||..||.::..|. |:....|.    
  Fly   553 LRNVTFDQEG-WYTCLASSGLGR-----SNSSVYLRVVSPLPPLEIYALLHAHPLGFTLAAITIV 611

  Fly   284 --YLLSSGINGSFLVRESESSPGQRSISLRYE------GRVYHYRISEDPDGKVFVTQEAKFNTL 340
              :||.|... :|::|....   ::.:.||.|      .:|..||    |.|:            
  Fly   612 ALFLLGSAFI-TFMLRRLRR---EKLLKLRIETVHQWTKKVIIYR----PGGE------------ 656

  Fly   341 AELVHHHSVPHEGHG-----LITPLLYPAPKQNKPTV------------------FPLSPEPDEW 382
                       ||.|     |..|::  ..::.:.||                  |||.   ..|
  Fly   657 -----------EGSGCSSGDLQMPVI--RIEKQRTTVSTTGTGGTDPAQGFNEYEFPLD---SNW 705

  Fly   383 EICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT-------VAVKTLKE---DTMALKDFLEEAAIM 437
            ||.|..:.:...||.|.:|.|..|..:....:       ||||.:||   || .:...:.|..:|
  Fly   706 EIPRQQLSLGSILGEGAFGRVVMAEAEGLPRSPQLAETIVAVKMVKEEHTDT-DMASLVREMEVM 769

  Fly   438 KEM-KHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFL----------RSAGRETLDAVALL--- 488
            |.: ||.|::.|:|.|::..|.::|.|:..||||.|||          ||.....||...|:   
  Fly   770 KMIGKHINIINLLGCCSQGGPLWVIVEYAPHGNLKDFLKQNRPGAPQRRSDSDGYLDDKPLISTQ 834

  Fly   489 --------YMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRD-DTYTAHA 544
                    ..|.|||.||.||.||..|||||||||.||.|..::|:|||||||.::| :.|..:.
  Fly   835 HLGEKELTKFAFQIARGMEYLASRRCIHRDLAARNVLVSDGYVMKIADFGLARDIQDTEYYRKNT 899

  Fly   545 GAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAI-DLTDVYHKLDKGYRMERP 608
            ..:.||||.|||.|...|:.::||||::|||||||.|||..|||.| ...::|..|..|.|||:|
  Fly   900 NGRLPIKWMAPESLQEKKYDSQSDVWSYGVLLWEIMTYGDQPYPHILSAEELYSYLITGQRMEKP 964

  Fly   609 PGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSASSS-----A 668
            ..|...:|.:|||||.:::..||||..:..:.:.:.|::|        .|.|......|     .
  Fly   965 AKCSLNIYVVMRQCWHFESCARPTFAELVESFDGILQQAS--------SNPNDAYLDLSMPMLET 1021

  Fly   669 PSTSGVATGGGATTT 683
            |.:||....|..|.|
  Fly  1022 PPSSGDEDDGSDTET 1036

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 10/38 (26%)
SH2_ABL 268..363 CDD:198189 22/112 (20%)
PTKc_Abl 382..644 CDD:270645 119/295 (40%)
FABD 1584..1723 CDD:197885
btlNP_729956.1 Ig 143..215 CDD:472250
Ig strand B 160..164 CDD:409570
Ig strand C 175..179 CDD:409570
Ig strand E 197..201 CDD:409570
Ig strand F 211..215 CDD:409570
Ig_3 247..333 CDD:464046
Ig 398..479 CDD:472250
Ig strand B 412..416 CDD:409393
Ig strand C 423..427 CDD:409393
Ig strand E 445..449 CDD:409393
Ig strand F 459..464 CDD:409393
Ig strand G 472..475 CDD:409393
IG_like 492..583 CDD:214653 9/35 (26%)
Ig strand B 503..507 CDD:409444
Ig strand C 516..520 CDD:409444
Ig strand E 549..553 CDD:409444 170/535 (32%)
Ig strand F 563..568 CDD:409444 2/4 (50%)
Ig strand G 576..579 CDD:409444 1/2 (50%)
Protein Kinases, catalytic domain 700..1000 CDD:473864 121/303 (40%)
Blue background indicates that the domain is not in the aligned region.

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