Protein Alignment Abl and LCK

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001426075.1
• Gene: LCK / 3932
• HGNCID: 6524
• Length: 567
• Species: Homo sapiens
• Alignment Length: 570
• Identity: 229/570 - (40%)
• Similarity: 310/570 - (54%)
• Gaps: 67/570 - (11%)

  Fly   121 HPGKYHMNLEALLQSRPLPHIPAGSTAASLLADAAELQQH--------------QQDSGGLGLQG 171
            ||....|....:.::...|.:|.......|:.:.:|::..              |.|....||:.
Human     8 HPEDDWMENIDVCENCHYPIVPLDGKGTLLIRNGSEVRDPLVTYEGSNPPASPLQGDPRQQGLKD 72

  Fly   172 SSLG----GGHSSTT-----SVFESAHRWTSKENLLAPG-----------PEEDDPQLFVALYDF 216
            .:.|    |.|.|.|     ..|...|..|       ||           |......|.:||:.:
Human    73 KACGSLAVGFHLSPTYFLPGLAFLVPHPVT-------PGFLPIPARFSLMPLVFTDNLVIALHSY 130

  Fly   217 QAGGENQLSLKKGEQVRILSYNKSGEWCEAHS-DSGNVGWVPSNYVTPLNSLEKHSWYHGPISRN 280
            :...:..|..:||||:|||  .:||||.:|.| .:|..|::|.|:|...||||...|:...:||.
Human   131 EPSHDGDLGFEKGEQLRIL--EQSGEWWKAQSLTTGQEGFIPFNFVAKANSLEPEPWFFKNLSRK 193

  Fly   281 AAE-YLLSSG-INGSFLVRESESSPGQRSISLR----YEGRVY-HYRISEDPDGKVFVTQEAKFN 338
            .|| .||:.| .:||||:|||||:.|..|:|:|    .:|.|. ||:|....:|..:::....|.
Human   194 DAERQLLAPGNTHGSFLIRESESTAGSFSLSVRDFDQNQGEVVKHYKIRNLDNGGFYISPRITFP 258

  Fly   339 TLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSP-EPDEWEICRTDIMMKHKLGGGQYGE 402
            .|.|||.|::  :...||.|.|..|...|.     |..| ..||||:.|..:.:..:||.||:||
Human   259 GLHELVRHYT--NASDGLCTRLSRPCQTQK-----PQKPWWEDEWEVPRETLKLVERLGAGQFGE 316

  Fly   403 VYEAVWKRY--GNT-VAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEF 464
                ||..|  |:| ||||:||:.:|:...||.||.:||:::|..||:|..|.|:| |.|||||:
Human   317 ----VWMGYYNGHTKVAVKSLKQGSMSPDAFLAEANLMKQLQHQRLVRLYAVVTQE-PIYIITEY 376

  Fly   465 MSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADF 529
            |.:|:|:|||::.....|....||.||.|||.||:::|.||||||||.|.|.||.|....|:|||
Human   377 MENGSLVDFLKTPSGIKLTINKLLDMAAQIAEGMAFIEERNYIHRDLRAANILVSDTLSCKIADF 441

  Fly   530 GLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTD 594
            |||||:.|:.|||..||||||||||||.:.|..|:.|||||:||:||.||.|:|..|||.:...:
Human   442 GLARLIEDNEYTAREGAKFPIKWTAPEAINYGTFTIKSDVWSFGILLTEIVTHGRIPYPGMTNPE 506

  Fly   595 VYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMF 644
            |...|::||||.||..||.|:|.|||.||:....|||||..:...||..|
Human   507 VIQNLERGYRMVRPDNCPEELYQLMRLCWKERPEDRPTFDYLRSVLEDFF 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	22/54 (41%)
		SH2_ABL	268..363	CDD:198189	38/101 (38%)
		PTKc_Abl	382..644	CDD:270645	137/264 (52%)
		FABD	1584..1723	CDD:197885
LCK	NP_001426075.1	None