Protein Alignment Abl and Egfr

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_476759.1
• Gene: Egfr / 37455
• FlyBaseID: FBgn0003731
• Length: 1426
• Species: Drosophila melanogaster
• Alignment Length: 450
• Identity: 149/450 - (33%)
• Similarity: 217/450 - (48%)
• Gaps: 83/450 - (18%)

  Fly   356 LITPLLYPAPKQNKPTV------------FPLSPEPDEWEICRTDIMMKHK------LGGGQYGE 402
            ::|.:.....|..|.||            .||.|......:|:..|:...:      ||.|.:|.
  Fly   887 VVTYICRQKQKAKKETVKMTMALSGCEDSEPLRPSNIGANLCKLRIVKDAELRKGGVLGMGAFGR 951

  Fly   403 VYEAVWKRYGNT----VAVKTLKEDTMA--LKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYII 461
            ||:.||...|..    ||:|.|.:.|.|  .::||.||.||..::|.||::|:.|| ......:|
  Fly   952 VYKGVWVPEGENVKIPVAIKELLKSTGAESSEEFLREAYIMASVEHVNLLKLLAVC-MSSQMMLI 1015

  Fly   462 TEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKV 526
            |:.|..|.|||::|: .|:.:.:.|||..:||||.||||||.:..:||||||||.||....|||:
  Fly  1016 TQLMPLGCLLDYVRN-NRDKIGSKALLNWSTQIAKGMSYLEEKRLVHRDLAARNVLVQTPSLVKI 1079

  Fly   527 ADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPA 589
            .|||||:|:..|:  |.| ||.|.||||.|.|.:....|::|||||||||.:||:.|:|..|:..
  Fly  1080 TDFGLAKLLSSDSNEYKA-AGGKMPIKWLALECIRNRVFTSKSDVWAFGVTIWELLTFGQRPHEN 1143

  Fly   590 IDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQE-------- 646
            |...|:...::.|.::|:|..|..::|..:..||..||..|||||.    |..:|.|
  Fly  1144 IPAKDIPDLIEVGLKLEQPEICSLDIYCTLLSCWHLDAAMRPTFKQ----LTTVFAEFARDPGRY 1204

  Fly   647 -----------SSITEAVEKQLNANATSASSSAPSTSG---VATGGGATTTTAASGCASSSSATA 697
                       .:.|...||.|      ....||:|.|   :|.........||.|.:..:..|.
  Fly  1205 LAIPGDKFTRLPAYTSQDEKDL------IRKLAPTTDGSEAIAEPDDYLQPKAAPGPSHRTDCTD 1263

  Fly   698 SLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQM 757
            .:   |::             |.:..||..:.:||...||.|::.::      |.||:::
  Fly  1264 EI---PKL-------------NRYCKDPSNKNSSTGDDETDSSAREV------GVGNLRL 1301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189	1/6 (17%)
		PTKc_Abl	382..644	CDD:270645	114/275 (41%)
		FABD	1584..1723	CDD:197885
Egfr	NP_476759.1	Recep_L_domain	128..239	CDD:460032
		Furin-like	253..401	CDD:395614
		Recep_L_domain	419..547	CDD:460032
		GF_recep_IV	572..684	CDD:464344
		FU	662..716	CDD:214589
		GF_recep_IV	740..>834	CDD:464344
		PTKc_EGFR_like	930..1208	CDD:270648	115/284 (40%)