DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and ripk2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_919392.3 Gene:ripk2 / 373874 ZFINID:ZDB-GENE-030902-3 Length:584 Species:Danio rerio


Alignment Length:494 Identity:122/494 - (24%)
Similarity:206/494 - (41%) Gaps:113/494 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   387 TDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDT----MALKDFLEEAAIMKEMKHPNLVQ 447
            ||:   |.:..|.:|.|:.|....:..|||:|.||.|:    ......|:||.::.:.:..:::|
Zfish    29 TDL---HYISKGGFGTVFRAQHSDWRTTVAIKCLKLDSPVGERERNCLLKEAEVLHKARFNHIIQ 90

  Fly   448 LIGVCTREPPFY-IITEFMSHGNLLDFLRSAGRETLDAVA------LLYMATQIASGMSYLESRN 505
            :.||| .||.|: ||||:|::|:|.:.|..  ::...|||      :||   :||.|:::|.:.:
Zfish    91 IFGVC-NEPEFFCIITEYMTNGSLDELLHE--KDIYPAVAWPLRLRILY---EIALGVNFLHNMS 149

  Fly   506 --YIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFP------IKWTAPEGLAYNK 562
              .:|.||..:|.|:.....||:|||||:: .|..:.|..:|:| |      :.:..||....:|
Zfish   150 PPLLHHDLKTQNILMDGEYHVKIADFGLSK-WRQLSITKGSGSK-PAEMGGTVIYMPPEEYEPSK 212

  Fly   563 ---FSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMER-----PPGCPPE--VYD 617
               ...|.|::::.:::||:.:..:....|.:...:...:.:|.|.:.     |...|..  :.:
Zfish   213 TRRTDVKYDMYSYAIIMWEVLSRRIPFEEATNPMQIMFSVLRGARPDTGLDSLPVDIPSRETLIN 277

  Fly   618 LMRQCWQWDATDRPTFKSIHHALEHM---FQESSITEAVEKQLNANATSASSSAPSTSGVATGGG 679
            ||...|..:..:||:|......||.|   |.|..:.|||.:.........||             
Zfish   278 LMTSGWTANPDERPSFLHCLIELEPMLRRFDEIDVLEAVLEVKRIKYRRPSS------------- 329

  Fly   680 ATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKL 744
                     |.||:.:... .:..:.||:             .|.|....:||  |.:||.|::.
Zfish   330 ---------CCSSTQSNGK-KIEEKCVKE-------------LNVPWPDNSST--SGSGSCSSQE 369

  Fly   745 STFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLSTNGIH- 808
            :..|..|...:    :|..||..|..|....||             |.:.....:|:.|.|.:. 
Zfish   370 AEISQPGFLTI----STPSQGAYAGLPSSLMSL-------------PLDPPKPLMDNCSPNNLSP 417

  Fly   809 KLKTANYFSQTLSRNFKTQIP-------------THHTH 834
            :.:||...|. |:..||...|             |.|.|
Zfish   418 EYQTAQVVSD-LNIPFKAHAPQSESELALAIQPLTLHPH 455

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189
PTKc_Abl 382..644 CDD:270645 79/288 (27%)
FABD 1584..1723 CDD:197885
ripk2NP_919392.3 None
Blue background indicates that the domain is not in the aligned region.

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