Protein Alignment Abl and Fak

DIOPT Version :9

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001137718.1
• Gene: Fak / 37233
• FlyBaseID: FBgn0020440
• Length: 1500
• Species: Drosophila melanogaster
• Alignment Length: 1501
• Identity: 322/1501 - (21%)
• Similarity: 513/1501 - (34%)
• Gaps: 472/1501 - (31%)

  Fly   194 KENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPS 258
            ||.|...|....:|:    |.:|....:     |...|::|             |.|.||    .
  Fly   318 KEKLSKSGENTTEPE----LQNFNCNCQ-----KIKTQIKI-------------SASNNV----E 356

  Fly   259 NYVTPLNSLEKHSWYHGPISRNAAE----------YLLSSGINGSFLVRESESSPGQRSISLRYE 313
            :.|...|.:            |.||          .|||..:..:...||:.:|....:.:|..:
  Fly   357 DLVITCNGI------------NTAESIADLIDGYCRLLSKDLEFTIWHRETNASNEDSAKALPND 409

  Fly   314 GRVYHYRISEDPDGKVFVTQE-AKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSP 377
            ..:...: |....||..:|.: |:...|           ||.|          ..:.|||
  Fly   410 ATLGSNK-STSSQGKPMLTDDYAEIGLL-----------EGEG----------DYSTPTV----- 447

  Fly   378 EPDEWEICRTDIMMKHKLGGGQYGEVYEAVW---------KRYGN------------------TV 415
              ..:|:.|..|....|:|.||:|:||...:         ...||                  .|
  Fly   448 --RNYELDRALITPSAKIGVGQFGDVYVGTYTLPKLGKGKNLAGNGKNSNSDQRNADSRPDVIQV 510

  Fly   416 AVKTLK--EDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAG 478
            |:||.|  :|....::||.||.||::..||::::|||:|: ..|.:|:.|....|.|..:|:: .
  Fly   511 AIKTCKANDDPEKTENFLAEAYIMQKFDHPHIIRLIGICS-VMPIWIVMELAKLGELRAYLKT-N 573

  Fly   479 RETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAH 543
            .|.|....||....|:::.:|||||:.::|||:||||.||.....||:|||||:|.:.|.:| .|
  Fly   574 SERLSHGTLLKYCYQLSTALSYLESKKFVHRDIAARNVLVSSPTCVKLADFGLSRWVSDQSY-YH 637

  Fly   544 A--GAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRME 606
            :  ....||||.:||.:.:.:|:|.||||.|||.:|||...|:.|:..:..:||..||:.|.|:.
  Fly   638 STPTVALPIKWMSPESINFRRFTTASDVWMFGVCIWEILMLGVKPFQGVKNSDVILKLENGERLP 702

  Fly   607 RPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSI--TEAVEKQLNANATSASSSAP 669
            .||.|||.:|.||.|||.::...||.||.|...|..:..|.||  :|.::::        .....
  Fly   703 LPPNCPPRLYSLMSQCWAYEPLKRPNFKRIKETLHEILIEDSINSSETLKRE--------QRKVA 759

  Fly   670 STSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKGLPGGQALTPN----AHHNDPHQQQA 730
            |.|.:.:.......:..|........|   .|.|:..  |||....:..|    |.....:|::.
  Fly   760 SMSWIGSDDIDIPPSKPSRVMHDPDIT---GLMPETT--GLPQTYIIAQNPAVLAKLMMENQKRG 819

  Fly   731 STPMSETGSTSTKLSTFSSQGKG------NVQMRRTTNKQGKQAPAPP--KRTSLLSSSRDSTYR 787
            ..|.:.|    |..|.|::...|      ||.::.|      :.||..  |...:..|.|   .|
  Fly   820 INPAAYT----TPASVFNTLAVGLDDSNPNVSLKTT------KLPAADLLKLDPIAESER---LR 871

  Fly   788 EEDPANARCNFIDDLSTNGIHKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQ 852
            .:..||:..:.:.:..|..::..::.|                  :|    |......|:..:..
  Fly   872 SQFSANSSASQLANPLTASVNPHESLN------------------SH----QAGMFTGSLPSKSS 914

  Fly   853 IVPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDA 917
            .|....|.:.|.|.:.....|:.|.|..|  ||..|.|              .:..||
  Fly   915 FVVCPPQTEEHMQAENISNPSVSKVSGYS--LYGSLER--------------HQPPPA------- 956

  Fly   918 TGDSLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSK 982
                                  .::||.||       |.::|.|        :|..:.|....:|
  Fly   957 ----------------------KAMHSKGG-------SLERHQS--------LMSAQNLVFYNTK 984

  Fly   983 RSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSL 1047
                        ||.                         |......|..::.:.....||...:
  Fly   985 ------------PPP-------------------------NCTNTAERSRSMERNTYFHAYRQQM 1012

  Fly  1048 EDSSEAAPALPATAPSLPPANGHATPPAARLNPKASP---IPP--------------QQMIRSNS 1095
            :.|.| ..|||...... ...|..|..:||..||.||   :.|              ||.|..:|
  Fly  1013 KTSIE-CEALPEEIYDF-GGIGLKTCVSARQQPKFSPMVNVRPAELGQVQNTDCMGLQQNIPMDS 1075

  Fly  1096 SGGVTMQNNAAASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQPALANLEFPP 1160
            .|.::..|     |::..||:...|...||                     ||.|....|
  Fly  1076 FGVISPHN-----LDESLRHQREMERQWMT---------------------SGPQSITVN----- 1109

  Fly  1161 PPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNNDSSHNDVSNIAP 1225
            |.:.:.      ||.             |....|.|:...|..|.|..|........:..|:...
  Fly  1110 PNISIS------EGA-------------ACLATLQAEAMGNQGIHNVLGEKLRQQQKDSNSDSEW 1155

  Fly  1226 SVEEASSRFGVSLRKREPSTDSCS-SLGSPPEDLKEKLITEIKAAGKDTAPASHLANGSGIAVVD 1289
            .::|...|             ||| ..||..:...:....:..:||..:.|
  Fly  1156 LIQEELLR-------------SCSIPQGSLNDHQAQMFKLDFMSAGPSSLP-------------- 1193

  Fly  1290 PVSLLVTELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVE-----PKKMSAPMPKAEPANT 1349
                   :.:.|.:.|..|......|.:.:|:.....:.....|     .:.:.:.:|...|
  Fly  1194 -------DCSNSSSRPMTPNANLSSLKSNHSSADHLSSLTSAEEQMGSNARNLGSAVPSRPP--- 1248

  Fly  1350 IIDFKAHLRRVDKEKEPATPAPAPATVAVANNA-NCNTTGTLNRKEDGSKKF------------- 1400
                    .|.|.|...||.....:.:|::... ..||.|.|...::...|.
  Fly  1249 --------NRADDEVYCATTLVVKSIMALSQGVEKANTEGYLELVKNVGVKLRNLLTSVDKISII 1305

  Fly  1401 --SQAMQKTEIKIDVTNSNVEADAGAAGEGDLGKRRSTGSINSLKKLWEQQPPAPDYATSTI-LQ 1462
              :||:::.::...|.:.::.                  .:.|..:|.:|      |:.:|: .:
  Fly  1306 FPAQALKEVQMAHQVLSKDMH------------------ELVSAMRLAQQ------YSDTTLDCE 1346

  Fly  1463 QQPSVVNGGGTPNAQLSPKYGMKSGAIN---TVGTLPAKLGNKQPPAAPPPPPPNCTTSNSSTTS 1524
            .:.|:          ||..:.:...|.|   .|.::..:..:..||:|        |...|.::|
  Fly  1347 YRKSM----------LSAAHVLAMDAKNLFDVVDSIRQRYQHLFPPSA--------TKETSCSSS 1393

  Fly  1525 ISTSSRDCTSR--QQASSTIKTSHS------TQLFTDDEEQSHTEGLG----------SGGQGSA 1571
            ..::|....:.  ......||||.|      |.::.:|...|....|.          ||| ||.
  Fly  1394 FESTSGSIVAEPVNDLGGYIKTSTSGDLLQNTGIYDNDLHHSFNSQLQLQNPKASIDLSGG-GSL 1457

  Fly  1572 DMTQSL 1577
            ....||
  Fly  1458 QRGMSL 1463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	10/53 (19%)
		SH2_ABL	268..363	CDD:198189	19/105 (18%)
		PTKc_Abl	382..644	CDD:270645	109/292 (37%)
		Pkinase_Tyr	389..640	CDD:285015	106/281 (38%)
		FABD	1584..1723	CDD:197885
Fak	NP_001137718.1	B41	24..267	CDD:214604
		FERM_B-lobe	152..257	CDD:271216
		FERM_C_FAK1	263..394	CDD:270011	22/113 (19%)
		PTKc_FAK	450..744	CDD:133187	110/296 (37%)
		Pkinase_Tyr	462..736	CDD:285015	105/276 (38%)
		Focal_AT	1249..1376	CDD:281606	25/160 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468395
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840