Protein Alignment Abl and JAK2

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_004963.1
• Gene: JAK2 / 3717
• HGNCID: 6192
• Length: 1132
• Species: Homo sapiens
• Alignment Length: 605
• Identity: 159/605 - (26%)
• Similarity: 247/605 - (40%)
• Gaps: 176/605 - (29%)

  Fly   173 SLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYD----------FQAG------GE 221
            |||.|  :.|.:|:...|.......|      .:.::.:.:.|          |:|.      ..
Human   550 SLGQG--TFTKIFKGVRREVGDYGQL------HETEVLLKVLDKAHRNYSESFFEAASMMSKLSH 606

  Fly   222 NQLSLKKG------EQVRILSYNKSGE---WCEAHSDSGNVGW---VPSNYVTPLNSLEKHSWYH 274
            ..|.|..|      |.:.:..:.|.|.   :.:.:.:..|:.|   |.......::.||:::..|
Human   607 KHLVLNYGVCVCGDENILVQEFVKFGSLDTYLKKNKNCINILWKLEVAKQLAWAMHFLEENTLIH 671

  Fly   275 GPISRNAAEYLLSSGINGSFLVRESE-----------SSPGQRSISLRYEGR-VYHYRIS----- 322
            |.:   .|:.:|        |:||.:           |.||   ||:....: :...||.
Human   672 GNV---CAKNIL--------LIREEDRKTGNPPFIKLSDPG---ISITVLPKDILQERIPWVPPE 722

  Fly   323 --EDPDGKVFVTQEAKF-NTLAELVHHHSVP-------------HEGHGLITPLLYPAPK----- 366
              |:|......|.:..| .||.|:......|             .:.|.|      ||||
Human   723 CIENPKNLNLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDRHQL------PAPKWAELA 781

  Fly   367 ---QNKPTVFPLSPEPD------------------EWEICRTDIMM------------------- 391
               .|     .:..|||                  ::|:...:.|:
Human   782 NLINN-----CMDYEPDFRPSFRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDP 841

  Fly   392 -----KH-----KLGGGQYGEV----YEAVWKRYGNTVAVKTLKEDTMA-LKDFLEEAAIMKEMK 441
                 :|     :||.|.:|.|    |:.:....|..||||.|:..|.. |:||..|..|:|.::
Human   842 TQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQ 906

  Fly   442 HPNLVQLIGVC--TREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESR 504
            |.|:|:..|||  .......:|.|::.:|:|.|:|:. .:|.:|.:.||...:||..||.||.::
Human   907 HDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQK-HKERIDHIKLLQYTSQICKGMEYLGTK 970

  Fly   505 NYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNKFSTKS 567
            .|||||||.||.||.:...||:.||||.:::..|.  |......:.||.|.|||.|..:|||..|
Human   971 RYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVAS 1035

  Fly   568 DVWAFGVLLWEIATY---GMSPYPAIDL----TD------VYHKLD---KGYRMERPPGCPPEVY 616
            |||:|||:|:|:.||   ..|| ||..:    .|      |:|.::   ...|:.||.|||.|:|
Human  1036 DVWSFGVVLYELFTYIEKSKSP-PAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIY 1099

  Fly   617 DLMRQCWQWDATDRPTFKSI 636
            .:|.:||..:...||:|:.:
Human  1100 MIMTECWNNNVNQRPSFRDL 1119

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	12/81 (15%)
		SH2_ABL	268..363	CDD:198189	25/127 (20%)
		PTKc_Abl	382..644	CDD:270645	105/309 (34%)
		FABD	1584..1723	CDD:197885
JAK2	NP_004963.1	Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250	1..239
		FERM_F1	39..134	CDD:465733
		FERM_F2	143..261	CDD:436450
		FERM_C_JAK2	266..386	CDD:270141
		SH2_Jak2	386..482	CDD:198242
		PTK_Jak2_rpt1	545..806	CDD:270663	54/288 (19%)
		PTKc_Jak2_rpt2	844..1127	CDD:271107	103/278 (37%)