DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and ITK

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_005537.3	Gene:	ITK / 3702	HGNCID:	6171	Length:	620	Species:	Homo sapiens

Alignment Length:	461	Identity:	172/461 - (37%)
Similarity:	273/461 - (59%)	Gaps:	31/461 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 LAPGPEED-----DPQ--LFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGW 255
            |.|.||::     :|:  :.:||||:|.....:|:|::.|:..:|..::. .|......:|:.|:
Human   157 LPPTPEDNRRPLWEPEETVVIALYDYQTNDPQELALRRNEEYCLLDSSEI-HWWRVQDRNGHEGY 220

  Fly   256 VPSNYV---TPLNSLEKHSWYHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRV 316
            |||:|:   :| |:||.:.||:..|||:.|| .||.:|..|:|:||:|.:: |..::|:..:..|
Human   221 VPSSYLVEKSP-NNLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSRTA-GTYTVSVFTKAVV 283

  Fly   317 -------YHYRISEDPDG--KVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPA--PKQNKP 370
                   .||.|.|..|.  :.:|.::..|:::..|:::|.  |.|.||:|.|.||.  .:|..|
Human   284 SENNPCIKHYHIKETNDNPKRYYVAEKYVFDSIPLLINYHQ--HNGGGLVTRLRYPVCFGRQKAP 346

  Fly   371 TVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAA 435
            ....|  ...:|.|..:::....::|.||:|.|:...|.. .:.||:||::|..|:.:||:|||.
Human   347 VTAGL--RYGKWVIDPSELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIREGAMSEEDFIEEAE 408

  Fly   436 IMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSY 500
            :|.::.||.||||.|||..:.|..::.|||.||.|.|:||:. |....|..||.|...:..||:|
Human   409 VMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRTQ-RGLFAAETLLGMCLDVCEGMAY 472

  Fly   501 LESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFST 565
            ||....|||||||||||||:|:::||:|||:.|.:.||.||:..|.|||:||.:||..:::::|:
Human   473 LEEACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSS 537

  Fly   566 KSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDR 630
            |||||:||||:||:.:.|..||.....::|...:..|:|:.:|......||.:|..||:....||
Human   538 KSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASTHVYQIMNHCWKERPEDR 602

  Fly   631 PTFKSI 636
            |.|..:
Human   603 PAFSRL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	16/56 (29%)
		SH2_ABL	268..363	CDD:198189	34/104 (33%)
		PTKc_Abl	382..644	CDD:270645	109/255 (43%)
		Pkinase_Tyr	389..640	CDD:285015	107/248 (43%)
		FABD	1584..1723	CDD:197885
ITK	NP_005537.3	PH_Btk	7..148	CDD:269944
		SH3_ITK	174..229	CDD:212841	16/55 (29%)
		SH2_Tec_Itk	232..340	CDD:198259	38/110 (35%)
		PTKc_Itk	358..613	CDD:133243	108/253 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.920