DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Grap2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001030116.1 Gene:Grap2 / 366962 RGDID:1307605 Length:326 Species:Rattus norvegicus


Alignment Length:221 Identity:66/221 - (29%)
Similarity:99/221 - (44%) Gaps:60/221 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHG 275
            :|.:||.|.||::||...|:.::|||..:  ||.:|...| ..|:||.|::    .::...|:|.
  Rat     4 IAKFDFMASGEDELSFHTGDILKILSNQE--EWLKAELGS-QEGYVPKNFI----DIKFPEWFHE 61

  Fly   276 PISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTL 340
            .:||:.||.||.....|.|::|.|:||||..|||:|:|..|.|:::..|..|..|:..| ||.:|
  Rat    62 GLSRHQAENLLMGKEIGFFVIRASQSSPGDFSISVRHEDDVQHFKVMRDTKGNYFLWTE-KFPSL 125

  Fly   341 AELVHHHSVP-------------------HEGHGL--------------------ITPLL----- 361
            .:||.::...                   |.|:.|                    |.||:     
  Rat   126 NKLVDYYRTTSISKQKQIFLRDGTQDQQGHRGNSLDRRTQGGPPREVPSGTAGEEIRPLMNRKLS 190

  Fly   362 --YPA------PKQNKPTVFPLSPEP 379
              .|.      |.|..|..||..|:|
  Rat   191 DHLPLGTQQFHPHQQLPPQFPPGPQP 216

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 20/51 (39%)
SH2_ABL 268..363 CDD:198189 38/140 (27%)
PTKc_Abl 382..644 CDD:270645
FABD 1584..1723 CDD:197885
Grap2NP_001030116.1 SH3 2..53 CDD:473055 20/55 (36%)
SH2_Grb2_like 54..147 CDD:199828 32/93 (34%)
SH3_GRAP2_C 271..323 CDD:212883
Blue background indicates that the domain is not in the aligned region.

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