DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and Itk

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_001102295.2	Gene:	Itk / 363577	RGDID:	1311618	Length:	620	Species:	Rattus norvegicus

Alignment Length:	461	Identity:	172/461 - (37%)
Similarity:	273/461 - (59%)	Gaps:	31/461 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 LAPGPEED-----DPQ--LFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGW 255
            |.|.||::     :|:  |.:||||:|.....:|:|::.|:..:|..::. .|......:|:.|:
  Rat   157 LPPTPEDNRRSFQEPEETLVIALYDYQTNDPQELALRRDEEYYLLDSSEI-HWWRVQDKNGHEGY 220

  Fly   256 VPSNYV---TPLNSLEKHSWYHGPISRNAAE-YLLSSGINGSFLVRESESSPGQRSISLRYEGRV 316
            .||:|:   :| ||||.:.||:..|||:.|| .||.:|..|:|:||:|. :||..::|:..:..:
  Rat   221 APSSYLVEKSP-NSLETYEWYNKSISRDKAEKLLLDTGKEGAFMVRDSR-TPGTYTVSVFTKAII 283

  Fly   317 ---------YHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYP--APKQNKP 370
                     ||.:.:.|...:.:|.::..|:::..|:.:|.  :.|.||:|.|.||  :.:|..|
  Rat   284 SENNPCIKHYHIKETNDSPKRYYVAEKYVFDSIPLLIQYHQ--YNGGGLVTRLRYPVCSWRQKAP 346

  Fly   371 TVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAA 435
            ....|  ...:|.|..:::....::|.||:|.|:...|.. .:.||:||::|..|:.:||:|||.
  Rat   347 VTAGL--RYGKWVIQPSELTFVQEIGSGQFGLVHLGYWLN-KDKVAIKTIQEGAMSEEDFIEEAE 408

  Fly   436 IMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSY 500
            :|.::.||.||||.|||..:.|..::.|||.||.|.|:|||. |....|..||.|...:..||:|
  Rat   409 VMMKLSHPKLVQLYGVCLEQAPICLVFEFMEHGCLSDYLRSQ-RGLFAAETLLGMCLDVCEGMAY 472

  Fly   501 LESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFST 565
            ||....|||||||||||||:|:::||:|||:.|.:.||.||:..|.|||:||.:||..:::::|:
  Rat   473 LEKACVIHRDLAARNCLVGENQVIKVSDFGMTRFVLDDQYTSSTGTKFPVKWASPEVFSFSRYSS 537

  Fly   566 KSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDR 630
            |||||:||||:||:.:.|..||.....::|...:..|:|:.:|....|.||.:|..||:....||
  Rat   538 KSDVWSFGVLMWEVFSEGKIPYENRSNSEVVEDISTGFRLYKPRLASPHVYQVMNHCWKEKPEDR 602

  Fly   631 PTFKSI 636
            |.|..:
  Rat   603 PPFSRL 608

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	16/56 (29%)
		SH2_ABL	268..363	CDD:198189	31/104 (30%)
		PTKc_Abl	382..644	CDD:270645	111/255 (44%)
		Pkinase_Tyr	389..640	CDD:285015	109/248 (44%)
		FABD	1584..1723	CDD:197885
Itk	NP_001102295.2	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.920