DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Ripk2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_001178794.1 Gene:Ripk2 / 362491 RGDID:1309167 Length:539 Species:Rattus norvegicus


Alignment Length:419 Identity:105/419 - (25%)
Similarity:172/419 - (41%) Gaps:118/419 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   393 HKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMAL----KDFLEEAAIMKEMKHPNLVQLIGVCT 453
            |.|..|..|.|..|....:...||||.|...|..|    .|.|.||.|:.:.:...::.::|:| 
  Rat    22 HYLSRGASGTVSSARHADWRVRVAVKHLHIHTPLLDSERNDILREAEILHKARFSYILPILGIC- 85

  Fly   454 REPPFY-IITEFMSHGNLLDFLRSAGRETLDAVALLY-MATQIASGMSYLESRN--YIHRDLAAR 514
            .||.|. |:||:|.:|:|.:.|.........|..|.: :..:||.|::||.:.|  .:|.||..:
  Rat    86 NEPEFLGIVTEYMPNGSLNELLHRKTEYPEIAWPLRFRILHEIALGVNYLHNMNPPLLHHDLKTQ 150

  Fly   515 NCLVGDNKLVKVADFGLAR-----LMRDDTYTAHAGAKFPIKWTAPEG--LAY-----------N 561
            |.|:.:...||:|||||::     |.:..:|.           :||||  :.|           :
  Rat   151 NILLDNEFHVKIADFGLSKWRMMSLSQSRSYK-----------SAPEGGTIIYMPPENYEPGQKS 204

  Fly   562 KFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTD---VYHKLDKGYR----MERPPGCPPE---VY 616
            :.|.|.|::::.|::||:.:   ...|..::|:   :.:.:.:|:|    .|..|...|.   :.
  Rat   205 RASVKHDIYSYAVIMWEVLS---RKQPFEEVTNPLQIMYSVSQGHRPNTSEENLPFDIPHRGLMI 266

  Fly   617 DLMRQCWQWDATDRPTFKSIHHALE---HMFQESSITEAV------------------EKQ---- 656
            .|::..|..:..:||:|......||   ..|::.:..|||                  :|:    
  Rat   267 SLIQSGWAQNPDERPSFLKCLIELEPVLRTFEDITFLEAVIQLKKSKIQSASSTIHLCDKKMDLS 331

  Fly   657 ------------------LNANA----TSASSSAPSTSGVATGGGATTTTAAS----------GC 689
                              |:.||    ||.|.|||...|...||....:::.:          |.
  Rat   332 LNIPASHPPQEESCGSSLLSRNAGSPGTSRSLSAPQDKGFFHGGPQDCSSSKAYHCPGNHSWDGI 396

  Fly   690 ASSSSATA-------SLSLT---PQMVKK 708
            .|.|...|       |.|||   |.:|:|
  Rat   397 ISVSQEAAFCDRRASSCSLTVIRPLLVEK 425

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189
PTKc_Abl 382..644 CDD:270645 77/289 (27%)
FABD 1584..1723 CDD:197885
Ripk2NP_001178794.1 STKc_RIP2 20..303 CDD:270928 78/295 (26%)
CARD_RIP2_CARD3 437..523 CDD:176764
Blue background indicates that the domain is not in the aligned region.

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