Protein Alignment Abl and fgfr2

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_068081038.1
• Gene: fgfr2 / 352940
• ZFINID: ZDB-GENE-030323-1
• Length: 840
• Species: Danio rerio
• Alignment Length: 598
• Identity: 166/598 - (27%)
• Similarity: 259/598 - (43%)
• Gaps: 147/598 - (24%)

  Fly   178 HSSTTSVFE-SAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSG 241
            |:.|..|.| |.||                |.|       |||....::::.|:..:.:
Zfish   265 HTYTLDVVERSPHR----------------PIL-------QAGLPANVTVQVGQDAKFV------ 300

  Fly   242 EWCEAHSDS-GNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGIN-------------- 291
              |:.:||: .::.|        |....|:...:||........|.::|:|
Zfish   301 --CKVYSDAQPHIQW--------LQHYTKNGSRYGPDGLPYVRVLKTAGVNTTDKEIEVLYLPNV 355

  Fly   292 -----GSF-----------------LVRESESSPGQRSISLRY-EGRVYHYRI------------ 321
                 |.:                 .|..:|::|.:......| |..:|...:
Zfish   356 TFEDAGEYTCLAGNSIGISYHTAWLTVHPAETNPIETDYPPDYVEIAIYCIGVFLIACMVVIVVV 420

  Fly   322 ------SEDPDGKVFVTQEA--KFNTLAELVHHHSVPHEGHGLI---TPLLYPAPKQNKPTVFPL 375
                  ::.||   |.:|.|  |......|....:|..:....:   |||:....:::.....|:
Zfish   421 CRMRTSAKKPD---FSSQPAVHKLTKQIPLRRQVTVSSDSSSSMSSSTPLVRITTRRSSAHDDPI 482

  Fly   376 S----PEPDEWEICRTDIMMKHKLGGGQYGEVY-------------EAVWKRYGNTVAVKTLKED 423
            .    ||...||..|..:.:...||.|.:|:|.             |||      |||||.||:|
Zfish   483 PEYDLPEDPRWEFSRDKLTLGKPLGEGCFGQVVMAEALGIDKDKPKEAV------TVAVKMLKDD 541

  Fly   424 TMA--LKDFLEEAAIMKEM-KHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRS--------- 476
            ...  |.|.:.|..:||.: :|.|::.|:|.||::.|.|:|.|:.|.|||.::||:
Zfish   542 ATEKDLSDLVSEMEMMKMIGRHKNIINLLGACTQDGPLYVIVEYASKGNLREYLRARRPPGMEYS 606

  Fly   477 -----AGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMR 536
                 ...|.|....|:....|:|.||.||.|:..|||||||||.||.::.::|:|||||||.:.
Zfish   607 YDIARVSDEPLTFKDLVSCTYQVARGMEYLASQKCIHRDLAARNVLVTESNVMKIADFGLARDVH 671

  Fly   537 D-DTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLD 600
            : |.|......:.|:||.|||.|....::.:||||:||||:|||.|.|.||||.|.:.:::..|.
Zfish   672 NIDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVLMWEIFTLGGSPYPGIPVEELFKLLK 736

  Fly   601 KGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLNANATSAS 665
            :|:||::|..|..|:|.:|:.||...::.|||||.:...|:.:...::..|.::  |.|.....|
Zfish   737 EGHRMDKPANCTNELYMMMKDCWHAISSHRPTFKQLVEDLDRILTLATNEEYLD--LCAPVEQYS 799

  Fly   666 SSAPSTSGVATGG 678
            .|.|.|....:.|
Zfish   800 PSFPDTRSSCSSG 812

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	9/54 (17%)
		SH2_ABL	268..363	CDD:198189	24/154 (16%)
		PTKc_Abl	382..644	CDD:270645	113/292 (39%)
		FABD	1584..1723	CDD:197885
fgfr2	XP_068081038.1	Ig	56..148	CDD:472250
		Ig strand B	82..86	CDD:409353
		Ig strand E	114..118	CDD:409353
		Ig strand F	128..133	CDD:409353
		Ig strand G	141..144	CDD:409353
		IgI_2_FGFR	177..271	CDD:409443	2/5 (40%)
		Ig strand A	177..180	CDD:409443
		Ig strand A'	188..193	CDD:409443
		Ig strand B	197..205	CDD:409443
		Ig strand C	211..216	CDD:409443
		Ig strand C'	219..221	CDD:409443
		Ig strand D	230..233	CDD:409443
		Ig strand E	237..242	CDD:409443
		Ig strand F	251..258	CDD:409443
		Ig strand G	261..271	CDD:409443	2/5 (40%)
		IgI_3_FGFR2	279..383	CDD:409444	18/126 (14%)
		Ig strand A	279..282	CDD:409444	2/9 (22%)
		Ig strand A'	286..290	CDD:409444	0/3 (0%)
		Ig strand B	298..305	CDD:409444	1/14 (7%)
		Ig strand C	309..316	CDD:409444	2/14 (14%)
		Ig strand D	331..336	CDD:409444	0/4 (0%)
		Ig strand E	348..353	CDD:409444	0/4 (0%)
		Ig strand F	361..369	CDD:409444	1/7 (14%)
		Ig strand G	372..380	CDD:409444	0/7 (0%)
		PTKc_FGFR2	475..787	CDD:270679	116/317 (37%)