DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and Btk29A

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_001097121.1	Gene:	Btk29A / 34132	FlyBaseID:	FBgn0003502	Length:	786	Species:	Drosophila melanogaster

Alignment Length:	696	Identity:	246/696 - (35%)
Similarity:	354/696 - (50%)	Gaps:	114/696 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 VASVSPHCISSSSGVSSAPLGGGSTLRGSRIKSSSSGVASGSGSGGGGGGSGSGLSQRSGGHKDA 96
            |..|....:|...|...||.|....:....|.:|::   |.....|.|||||.|:.    |.:..
  Fly    97 VRLVEEATVSGEGGDPFAPDGYPFQVGYCEISASAN---SHQLENGNGGGSGVGIE----GQQSG 154

  Fly    97 RCNPTVGLNIFT-----------------EHNGTKHSSFRGHP----GKYHMNLEALLQS----R 136
            |..|...|.:..                 |.:.|. .|:|.||    ||.....:.|.::    |
  Fly   155 RAVPQYTLYVIANSEKERSEWIRAIRQVCEDSNTP-KSYRYHPGLWSGKKWSCCKGLSRTTFGCR 218

  Fly   137 PLPH------------IPAGSTAASLLADAA------ELQQHQQDS------------GGLGLQG 171
            ...|            .||.::..|:..:::      .||.:...|            |.|||.|
  Fly   219 AAAHWREANNNPSNGSSPAQNSTRSISPNSSTTNSQFSLQHNSSGSLGGGVGGGLGGGGSLGLGG 283

  Fly   172 SSLGGGHSSTTSVFESAHRWTSKEN---------LL---APG--PEEDDP-----------QLFV 211
            ...|||..:.||:...:...|.|::         ||   .||  |....|           :|.|
  Fly   284 GGGGGGSCTPTSLQPQSSLTTFKQSPTLLNGNGTLLDANMPGGIPTPGTPNSKAKDNSHFVKLVV 348

  Fly   212 ALYDFQA--GGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTP--LNSLEKHSW 272
            |||.|:|  ||:  |||:|..:..::. :....|.:.....||||::|||||.|  |..||::.|
  Fly   349 ALYPFKAIEGGD--LSLEKNAEYEVID-DSQEHWWKVKDALGNVGYIPSNYVKPKALLGLERYEW 410

  Fly   273 YHGPISRNAAEYLLSSG-INGSFLVRESESSPGQRSISLRY---EGRVYHYRISEDPDGKVFVTQ 333
            |.|.:||..||.||..| ..|.|:||:| |:.|..::||..   :..|.||.|.::...:.::::
  Fly   411 YVGDMSRQRAESLLKQGDKEGCFVVRKS-STKGLYTLSLHTKVPQSHVKHYHIKQNARCEYYLSE 474

  Fly   334 EAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSP----EPDEWEICRTDIMMKHK 394
            :....|:.:|:::|.  |...||...|      ::.|...|:.|    ..|:|||...::|:..:
  Fly   475 KHCCETIPDLINYHR--HNSGGLACRL------KSSPCDRPVPPTAGLSHDKWEIHPMELMLMEE 531

  Fly   395 LGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFY 459
            ||.||:|.|....|:...:| |||.:||.||:..||:|||.:|.:::|||||||.|||::..|.|
  Fly   532 LGSGQFGVVRRGKWRGSIDT-AVKMMKEGTMSEDDFIEEAKVMTKLQHPNLVQLYGVCSKHRPIY 595

  Fly   460 IITEFMSHGNLLDFLRSAGRETLDAVALLY-MATQIASGMSYLESRNYIHRDLAARNCLVGDNKL 523
            |:||:|.||:||::||...:..:..:.||. |..|::.||:|||..|||||||||||||||...:
  Fly   596 IVTEYMKHGSLLNYLRRHEKTLIGNMGLLLDMCIQVSKGMTYLERHNYIHRDLAARNCLVGSENV 660

  Fly   524 VKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYP 588
            ||||||||||.:.||.||:..|.||||||..||.|.|.:||:||||||:|||:|||.|.|..||.
  Fly   661 VKVADFGLARYVLDDQYTSSGGTKFPIKWAPPEVLNYTRFSSKSDVWAYGVLMWEIFTCGKMPYG 725

  Fly   589 AIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFK 634
            .:..|:|..::.:|..:|:|..|..|:||:|:.||.....:||.|:
  Fly   726 RLKNTEVVERVQRGIILEKPKSCAKEIYDVMKLCWSHGPEERPAFR 771

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	23/55 (42%)
		SH2_ABL	268..363	CDD:198189	31/98 (32%)
		PTKc_Abl	382..644	CDD:270645	129/254 (51%)
		Pkinase_Tyr	389..640	CDD:285015	126/247 (51%)
		FABD	1584..1723	CDD:197885
Btk29A	NP_001097121.1	PH_Btk	44..222	CDD:269944	31/132 (23%)
		SH3_Tec_like	346..399	CDD:212702	23/55 (42%)
		SH2_Tec_family	403..505	CDD:198188	33/110 (30%)
		PTKc_Tec_like	521..778	CDD:173637	127/252 (50%)
		Pkinase_Tyr	526..777	CDD:285015	126/247 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45468351
Domainoid	1	1.000	165	1.000	Domainoid score	I1208
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D17578at33392
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24418
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.950