Protein Alignment Abl and Map3k20

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001385922.1
• Gene: Map3k20 / 311743
• RGDID: 1561394
• Length: 802
• Species: Rattus norvegicus
• Alignment Length: 839
• Identity: 183/839 - (21%)
• Similarity: 301/839 - (35%)
• Gaps: 208/839 - (24%)

  Fly   388 DIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVC 452
            |:......|||.:|.||.|.|......||||.|      || ..:||.|:..:.|.|::|..||.
  Rat    15 DLQFFENCGGGSFGSVYRAKWISQDKEVAVKKL------LK-IEKEAEILSVLSHRNVIQFYGVI 72

  Fly   453 TREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESR---NYIHRDLAAR 514
            ...|.:.|:||:.|.|:|.|::.|...|.:|...::..||.:|.||.||...   ..|||||.:|
  Rat    73 LEPPNYGIVTEYASLGSLYDYINSNRSEEMDMEHIMTWATDVAKGMHYLHMEAPVKVIHRDLKSR 137

  Fly   515 NCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEI 579
            |.::..:.::|:.|||.:|.....|:.:..|. ||  |.|||.:.....|...|.:::||:|||:
  Rat   138 NVVIAADGVLKICDFGASRFHNHTTHMSLVGT-FP--WMAPEVIQSLPVSETCDTYSYGVVLWEM 199

  Fly   580 ATYGMSPYPAID-LTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHM 643
            .|..: |:..:: |...:..::|..|:..|..||....:|:.|||:.||..||:||.|...||.|
  Rat   200 LTREV-PFKGLEGLQVAWLVVEKNERLTIPSSCPRSFAELLHQCWEADAKKRPSFKQIISILESM 263

  Fly   644 FQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKK 708
            ..::::.:.....|:..|........:...:                  ......||...|.:|:
  Rat   264 SNDTNLPDQCNSFLHNKAEWRCEIEATLERL------------------KKLERDLSFKEQELKE 310

  Fly   709 G----LPGGQALTPNAHHNDPHQQQASTPM---SETGSTSTKLSTFSSQ---GKGNVQMRRTTNK 763
            .    ....|.||          :|::||:   .|.|:.:.:...|..|   |||
  Rat   311 RERRLKMWEQKLT----------EQSNTPLLPSFEIGAWTEEDVYFWVQQLVGKG---------- 355

  Fly   764 QGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFI--DDLSTNGIHKLKTANYFSQTLSRNFKT 826
                      .:|:..|...|.::|.:....|...:  :||...||.......:|...:.:....
  Rat   356 ----------ESSVEMSGYASLFKENNITGKRLLLLEEEDLKDMGIVSKGHIIHFKSAIEKLTHD 410

  Fly   827 QIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAH------QQQQKQQQY-SIKKSSSCSSFL 884
            .:...|...:.....::.:  :.:::||.|.:....|      .|..|.:.| .:.......:::
  Rat   411 YLNLFHFPPLIKDSGEEPE--ENEEKIVNLELVFGFHLKPGTGPQDCKWKMYMEMDGDEVAIAYI 473

  Fly   885 YDILFRGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQVIA------APVTNKMQHSLH 943
            .|:.|.....|...|..     |.|....:....|...:|::...:.      .|...|..||:.
  Rat   474 KDVTFNTSLPDAEILKM-----TKPPFVMEKWIVGIVKDQTVECTVTYESDVRTPKFTKHVHSIQ 533

  Fly   944 --------------------SGGGGGGIGPRSSQ----------------QHSSFKRPTGTPVMG 972
                                .....|..|.||..                .|||.:|....|::|
  Rat   534 WDRAKPQDEVKAVQLAIQTLFSSSEGNPGSRSDSSADCQWLDTLRMRQIASHSSLQRSQSNPILG 598

  Fly   973 NRGLE--------------TRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDVMN 1023
            :...:              |:...:.|..:.:..|...|:...:|.....:|.|         :|
  Rat   599 SPFFQYFVNQDSYAAAVRRTQTPVKYQQITPSINPSRSSSPTQYGLTKNFSSLH---------LN 654

  Fly  1024 VK-------------------QVVNRY-------GTLPKGARIGAYLDSLEDSSEAAPA----LP 1058
            .:                   :..|:|       .:.||| |.|........|.|..|.    ||
  Rat   655 SRDSGFSSLNDSSSERGRYSDRSRNKYYRGSVSLNSSPKG-RYGGKSQHSTPSRERYPGKFYRLP 718

  Fly  1059 ATAPSLPPANGHATP-----------------PAARLNPKASPIPPQQMIRSNSSGGVT 1100
            .:|     .|.|.:|                 |...|:|:.:|...::..|. |.||.|
  Rat   719 QSA-----LNTHQSPDFKRSPNDHDRRAPKTIPGMPLHPETAPKAGEEESRV-SEGGWT 771

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	90/259 (35%)
		FABD	1584..1723	CDD:197885
Map3k20	NP_001385922.1	STKc_MLTK	22..263	CDD:270962	89/251 (35%)
		SAM_MLTK	338..408	CDD:188928	15/89 (17%)