DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and Txk

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_001019426.1	Gene:	Txk / 305311	RGDID:	1306481	Length:	526	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	194/503 - (38%)
Similarity:	274/503 - (54%)	Gaps:	34/503 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   151 LADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEE-DDPQLFV-AL 213
            |::....:|.|..|..:|...||.||..             .||...|.|.|:| .:.::.| ||
  Rat    38 LSEKHSQRQRQWFSKLMGKSQSSRGGVQ-------------PSKRRPLPPLPQEFTEERIRVKAL 89

  Fly   214 YDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTP--LNSLEKHSWYHGP 276
            |||.......|:||:.|:..||. .....|..|....||.|.:||||||.  |.:||.:.|||..
  Rat    90 YDFLPREPCNLALKRAEEYLILE-RCDPHWWRARDRLGNEGLIPSNYVTENRLTNLETYEWYHKN 153

  Fly   277 ISRNAAEYLL-SSGINGSFLVRESESSPGQRSISLRYEGR------VYHYRISEDPDGKVFVTQE 334
            |:|:..|.|| .....|:|:||:|... |..:||:....|      :.||:|.::..|:.:||:.
  Rat   154 ITRDQTERLLRQEAKEGAFIVRDSRHL-GSYTISVFTRARRHTQSSIKHYQIKKNDSGQWYVTER 217

  Fly   335 AKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNK--PTVFPLSPEPDEWEICRTDIMMKHKLGG 397
            ..|.::.||:.:|.  :...||::.|.||......  |.....|.|  :|||..:::....::|.
  Rat   218 HLFPSVPELIQYHQ--YNAAGLMSRLRYPVGLLGSCLPATSGFSYE--KWEIDPSELTFVKEIGS 278

  Fly   398 GQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIIT 462
            ||:|.||...| |....||:|.:.|.:|:.:||:|||.:|.::.|..||||.|||.::.|.||:|
  Rat   279 GQFGVVYLGEW-RARIRVAIKAINEGSMSEEDFIEEAKVMMKLSHSRLVQLYGVCIQQKPLYIVT 342

  Fly   463 EFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVA 527
            |||.:|.|||:||.. :..|....||.|...|..||:|||...|||||||||||||....:||::
  Rat   343 EFMENGCLLDYLRER-KGKLPKALLLSMCQDICEGMAYLEKSCYIHRDLAARNCLVSSACVVKIS 406

  Fly   528 DFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDL 592
            |||:||.:.||.|.:.:|||||:||:.||...:||:|:|||||:||||:||:.|.|..|:.....
  Rat   407 DFGMARYVLDDEYISSSGAKFPVKWSPPEVFHFNKYSSKSDVWSFGVLMWEVFTEGKMPFENKSN 471

  Fly   593 TDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL 640
            ..|...:.||:|:.||...|..:|.:|..||......||||..:...|
  Rat   472 LQVVEAISKGFRLYRPHLAPMSIYGVMYSCWHESPKGRPTFAELLQVL 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	22/54 (41%)
		SH2_ABL	268..363	CDD:198189	31/101 (31%)
		PTKc_Abl	382..644	CDD:270645	118/259 (46%)
		Pkinase_Tyr	389..640	CDD:285015	114/250 (46%)
		FABD	1584..1723	CDD:197885
Txk	NP_001019426.1	SH3_TXK	84..138	CDD:212840	22/54 (41%)
		SH2_Tec_Txk	142..247	CDD:198261	34/107 (32%)
		PKc_like	265..520	CDD:304357	116/257 (45%)
		Pkinase_Tyr	270..519	CDD:285015	114/250 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1047190at2759
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	4.820