DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and Abl2

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	XP_038946666.1	Gene:	Abl2 / 304883	RGDID:	1590898	Length:	1188	Species:	Rattus norvegicus

Alignment Length:	1728	Identity:	556/1728 - (32%)
Similarity:	723/1728 - (41%)	Gaps:	620/1728 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GVASGSGSGGGGGGSGSGLSQRSGGHKDARCNPT-----VGLNIFTEHNGTKHSSFRGHPGKYHM 127
            |.|.|.......|..||..::.||..:|    |.     .|.|:||:|:
  Rat     9 GEAPGLQQPQPRGIRGSSAARPSGRRRD----PVGRTADAGFNVFTQHD---------------- 53

  Fly   128 NLEALLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGG----------GHSSTT 182
                        |.      ||.:.|              |.:|...||          |..:.:
  Rat    54 ------------HF------ASCVED--------------GFEGDKTGGSSPEVLHRPFGCDAES 86

  Fly   183 SVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAH 247
            .....|.||:||||||  |..|.||.||||||||.|.|:|.||:.|||::|:|.||::|||.|..
  Rat    87 QALNEAIRWSSKENLL--GATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVR 149

  Fly   248 SDSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRY 312
            |.:|. |||||||:||:||||||||||||:||:||||||||.||||||||||||||||.||||||
  Rat   150 SKNGQ-GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRY 213

  Fly   313 EGRVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSP 377
            |||||||||:...|.||:||.|::|:||||||||||...:  ||:|.|.|||||.|||||:.:||
  Rat   214 EGRVYHYRINTTTDSKVYVTAESRFSTLAELVHHHSTVAD--GLVTTLHYPAPKCNKPTVYGVSP 276

  Fly   378 EPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKH 442
            ..|:||:.||||.||||||||||||||..|||:|..||||||||||||.:::||:|||:|||:||
  Rat   277 IHDKWEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKH 341

  Fly   443 PNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYI 507
            ||||||:||||.||||||:||:|.:|||||:||...||.:.||.||||||||:|.|.|||.:|:|
  Rat   342 PNLVQLLGVCTLEPPFYIVTEYMPYGNLLDYLRECSREEVTAVVLLYMATQISSAMEYLEKKNFI 406

  Fly   508 HRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAF 572
            ||||||||||||:|.:||||||||:|||..|||||||||||||||||||.||||.||.|||||||
  Rat   407 HRDLAARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAF 471

  Fly   573 GVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIH 637
            ||||||||||||||||.|||:.||..|:||||||:|.||||:||:|||.||:|...|||:|...|
  Rat   472 GVLLWEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETH 536

  Fly   638 HALEHMFQESSITE------AVEKQLNANATSAS--------SSAPSTSGVATGGGATTTTA--- 685
            .|.|.||.:|||:|      .|.::|...|:|:|        ...||.:......|......
  Rat   537 QAFETMFHDSSISEDFVFFTEVAEELGRTASSSSVVPYLPRLPLLPSKTRTLKKQGENKENLDGG 601

  Fly   686 --ASGCASSSSATASLSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFS 748
              ||...:||||.|....:.|    ...|..||        |.:|:..:|.|..  ...|.:.|:
  Rat   602 LDASEILASSSAPAGFIRSTQ----ASSGSPAL--------PRKQRDKSPSSLL--EDAKETCFT 652

  Fly   749 SQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSSSRDSTYRE-EDPANARCNFIDDLSTNGIHKLKT 812
            ...||..   .::..:.:.||.||||:        |::|| |:..:.:.....:.|.  :..|:.
  Rat   653 RDRKGGF---FSSFMKKRNAPMPPKRS--------SSFREMENQPHKKYELTGNFSP--VASLQH 704

  Fly   813 ANYFSQTLSRNFKTQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKS 877
            |:.||.|..                          ||:..:||
  Rat   705 ADGFSFTPG--------------------------QQESNLVP---------------------- 721

  Fly   878 SSCSSFLYDILFRGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQVIAAPVTNKMQHSL 942
            :.|..              .|..||             :..||.
  Rat   722 AKCYG--------------GSFAQR-------------NLCGDD--------------------- 738

  Fly   943 HSGGGGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPGPGPPSTQPHHGNNGV 1007
            .||||||                :||...|..|:
  Rat   739 DSGGGGG----------------SGTAAGGWSGI------------------------------- 756

  Fly  1008 VTSAHPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPALPATAPSLPPANGHAT 1072
                    .|......:|:.:        |.|.|.                      |.|:...:
  Rat   757 --------TGFFTPRLIKKTL--------GLRAGK----------------------PTASDDTS 783

  Fly  1073 PPAARLNPKASPIPPQQMIRSNSSGGVTMQNNAAASL------NKLQRHRTTTEGTMMTFSSFRA 1131
            .|..|.|.           .|:.|.|:..|:..|.:|      :|||..||.:
  Rat   784 KPFPRSNS-----------TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVS------------ 825

  Fly  1132 GGSSSSPKRSASGVASGVQPALANLEFPPPPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQHLHA 1196
              :||.|:.:..         .||        |:  .|::.|.|..|....|::.:
  Rat   826 --TSSQPEENVD---------RAN--------DM--LPKKSEEGAAPARERPKAKL--------- 860

  Fly  1197 QLPNNGNISNGNGTNNNDSSHNDVSNIAPSVEEASSRFGVSLRKREPS-TDS-CSSLGSPPEDLK 1259
             ||....                               .::||..:|: |:| |..:|
  Rat   861 -LPRGAT-------------------------------ALALRAPDPAITESDCPGVG------- 886

  Fly  1260 EKLITEIKAAGKDTAPASHLANGS---GIAVVDPVSLLVTELAESMNLPKPPPQQQQKLTNGNST 1321
                    .||...||.....||.   |:|.|                    |:..:
  Rat   887 --------VAGVAAAPKGKERNGGTRLGVAGV--------------------PEDAE-------- 915

  Fly  1322 GSGFKAQLKKVEPKKMSAPMPKAEPANTIIDFKAHLRRVDKEKEPATPAPAPATVAVANNANCNT 1386
                                                       :|...:||.|...:....|
  Rat   916 -------------------------------------------QPGWSSPAKAVAVLPTTHN--- 934

  Fly  1387 TGTLNRKEDGSKKFSQAMQKTEIKIDVTNSNVEADAGAAGEGDLGKRRSTGSINSLKKLWEQQPP 1451
                              .|..:.|..|..:..||....|....|        |..|.|.|.|
  Rat   935 ------------------HKVPVLISPTLKHTAADVQLIGTDSQG--------NKFKLLSEHQ-- 971

  Fly  1452 APDYATSTILQQQPSVVNGGGTPNAQLSPKYGMKSGAINTVGTLPAKLGNKQPPAAPPPPPPNCT 1516
                .||:..:.:|..|                                  :|..||||||....
  Rat   972 ----VTSSGDKDRPRRV----------------------------------KPKCAPPPPPVMRL 998

  Fly  1517 TSNSSTTSISTSSRDCTSRQQASSTIKTSHSTQLFTDDEEQ-------SHTEGLGSGGQGSA--D 1572
            ..:.||.|                            |.||:       .||.....||:.:|  .
  Rat   999 LQHPSTCS----------------------------DPEEEPTAPPAGQHTPDTQDGGKKAAPGP 1035

  Fly  1573 MTQSLYEQKPQIQQKPAVP-----HKPTKLT--IYATPIA--KLTEPASSASSTQISRESILELV 1628
            :..|....:| :...|.||     ..|.|:.  ...|.:|  |..:.|...|:.:||:.::||..
  Rat  1036 VPSSGKPGRP-VMPPPQVPLPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKAALLECA 1099

  Fly  1629 GLLEGSLKHPVNAIAGSQWLQLSDKLNILHN-----SCVIFAENGAMPPH--SKFQFRELVTRVE 1686
            |||..::..||   ..||.:....:|  ||.     .|:         ||  :||.|||.|:::|
  Rat  1100 GLLSSAITEPV---PHSQLVDTGHQL--LHYCSGYVDCI---------PHTRNKFAFREAVSKLE 1150

  Fly  1687 AQSQHLR-SAGSKNVQDNERLVAEVGQSLRQISNALNR 1723
            ...|.|: |:.:..|.....::..:...:::||:.:.|
  Rat  1151 LSLQELQVSSTAAGVPGTNPVLNNLLSCVQEISDVVQR 1188

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	33/53 (62%)
		SH2_ABL	268..363	CDD:198189	71/94 (76%)
		PTKc_Abl	382..644	CDD:270645	195/261 (75%)
		Pkinase_Tyr	389..640	CDD:285015	188/250 (75%)
		FABD	1584..1723	CDD:197885	40/155 (26%)
Abl2	XP_038946666.1	SH3_Abl	111..164	CDD:212784	33/53 (62%)
		SH2_ABL	169..262	CDD:198189	71/94 (76%)
		PTKc_Abl	281..543	CDD:270645	195/261 (75%)
		FABD	1069..1188	CDD:197885	35/132 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	419	1.000	Domainoid score	I623
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	764	1.000	Inparanoid score	I519
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm46218
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	10	9.960