DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Abl and jak2b

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_571162.1 Gene:jak2b / 30298 ZFINID:ZDB-GENE-980526-123 Length:1126 Species:Danio rerio


Alignment Length:637 Identity:180/637 - (28%)
Similarity:259/637 - (40%) Gaps:157/637 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   126 HMNLEALLQSRPLPHIPAGSTAASLLADAAELQQHQQDS------GGLGLQGSSLGGGHSS--TT 182
            |..||..|.|....|..:......:..:..||.:.|...      .|:..:....|..|.:  ..
Zfish   499 HRGLEVPLSSSLQRHNISQMVFHKIKKEDLELGESQGQGTFTKIFKGIRKEQGDYGETHKTEVIV 563

  Fly   183 SVFESAHRWTSKENLLAPGPEEDDPQL----FVALYDF-QAGGEN---QLSLKKGEQVRILSYNK 239
            .|.:.|||..|:....|.....   ||    .|..|.. ..|.||   |..:|.|.....|..||
Zfish   564 KVLDKAHRNYSESFFEAASMMS---QLTHKHLVLTYGICVCGDENIMVQEYVKFGSLDTYLKKNK 625

  Fly   240 SGEWCEAHSDSGNVGW---VPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESE- 300
            |       |.|.|:.|   |.......:..||:.|..||.:   .|:.:|        |:||.: 
Zfish   626 S-------SVSVNILWKLEVAKQLAWAMLYLEEKSLAHGNV---CAKNIL--------LIREEDR 672

  Fly   301 ----------SSPGQRSISLRYEGR-VYHYRIS-------EDPDGKVFVTQEAKF-NTLAELVHH 346
                      |.||   ||:....| :...||.       .||......|.:..| .||.|:...
Zfish   673 ALGNTPFIKLSDPG---ISITVLPREILVERIPWVPPECILDPKNLSLATDKWSFGTTLWEICSG 734

  Fly   347 HSVP------------HEGHGLITPLLYPAPK------------QNKPTVFPLSPE--------- 378
            ...|            :|.|..:     ||||            ..:||..|....         
Zfish   735 GEQPLANMDNSKKHLFYENHHQL-----PAPKWTELANLINSCMDYEPTFRPSFKAIIRDLNSLF 794

  Fly   379 -PDEWEICRTDIM-----------------------MKH-----KLGGGQYGEV----YEAVWKR 410
             ||...:..:|||                       .:|     :||.|.:|.|    |:.:...
Zfish   795 CPDYEIVKESDIMPSRAAASIFNTGTFKNNEPVQFEERHLIFLQQLGKGNFGSVEMCRYDPLQDN 859

  Fly   411 YGNTVAVKTLKEDTMA-LKDFLEEAAIMKEMKHPNLVQLIGVC--TREPPFYIITEFMSHGNLLD 472
            .|..||||.|:..|.. ::||..|..|:|.::|.|:|:..|||  .......::.|::.:|:|.|
Zfish   860 TGEVVAVKKLQHSTTEHIRDFEREIEILKSLQHENIVKYKGVCYGAGRRNLRLVMEYLPYGSLRD 924

  Fly   473 FLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRD 537
            :| :..|:.:|...|::.|:||..||.||.::.|||||||.||.||.....||:.||||.:::..
Zfish   925 YL-NKNRDRIDHQKLVHYASQICKGMEYLATKRYIHRDLATRNILVESECRVKIGDFGLTKVLPQ 988

  Fly   538 DT--YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYG---MSPYPAIDL----- 592
            |.  |......:.||.|.|||.|..:|||..||||:|||:|:|:.||.   .|| |.:.|     
Zfish   989 DKEYYKVKEPGESPIFWHAPESLTESKFSVASDVWSFGVVLYELFTYSDKLCSP-PTVFLSMVGG 1052

  Fly   593 -----TDVYHKLD---KGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSI 636
                 |.|||.::   :|.|:.:|.|||.|::::|::||..|.:.||.||.:
Zfish  1053 DKQGQTIVYHLIELLKRGNRLPQPMGCPTEMFEIMQECWDNDPSLRPNFKEL 1104

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 18/64 (28%)
SH2_ABL 268..363 CDD:198189 27/126 (21%)
PTKc_Abl 382..644 CDD:270645 106/308 (34%)
FABD 1584..1723 CDD:197885
jak2bNP_571162.1 FERM_F1 30..126 CDD:465733
FERM_F2 134..253 CDD:436450
FERM_C_JAK2 258..370 CDD:270141
SH2_Jak2 370..466 CDD:198242
Protein Kinases, catalytic domain 528..791 CDD:473864 66/291 (23%)
Protein Kinases, catalytic domain 829..1112 CDD:473864 103/278 (37%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.