DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Zap70

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:XP_006244823.1 Gene:Zap70 / 301348 RGDID:3983 Length:638 Species:Rattus norvegicus


Alignment Length:433 Identity:150/433 - (34%)
Similarity:223/433 - (51%) Gaps:63/433 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly   268 EKHSWYHGPISRNAAEYLLSSG--INGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVF 330
            |:..|||..::|..||..|.||  .:|.||:|..:.. |..::||.|...||||.||:|..||..
  Rat   183 ERMPWYHSSLTREEAERKLYSGQQTDGKFLLRPRKEQ-GTYALSLVYGKTVYHYLISQDKAGKYC 246

  Fly   331 VTQEAKFNTLAELVHHHSVPHEG---------------------------------HGLITPL-- 360
            :.:..||:||.:||.:..:..:|                                 |..|..|  
  Rat   247 IPEGTKFDTLWQLVEYLKLKADGLIYRLKEVCPNSSASAEAAAPTLPAHPSTFTQPHRRIDTLNS 311

  Fly   361 --LYPAP-KQNKPTVFPL------SPEPDEWEICRTDIMMKH--------KLGGGQYGEVYEAVW 408
              ..|.| :.:||...|:      ||..|..|:....:.:|.        :||.|.:|.|.:.|:
  Rat   312 DGYTPEPARLDKPRPMPMDTSVYESPYSDPEELKDKKLFLKRENLLVADIELGCGNFGSVRQGVY 376

  Fly   409 --KRYGNTVAVKTLKEDT-MALKD-FLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGN 469
              ::....||:|.||:.| .|.|| .:.||.||.::.:|.:|:|||||..| ...::.|....|.
  Rat   377 RMRKKQIDVAIKVLKQSTEKADKDEMMREAQIMHQLDNPYIVRLIGVCQAE-ALMLVMEMAGGGP 440

  Fly   470 LLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLAR- 533
            |..|| ...:|.:....:..:..|:|.||.|||.:|::||||||||.|:.:....|::||||:: 
  Rat   441 LHKFL-IGKKEEIPVSNVAELLHQVAMGMKYLEEKNFVHRDLAARNVLLVNRHYAKISDFGLSKA 504

  Fly   534 LMRDDT-YTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYH 597
            |..||: |||.:..|:|:||.|||.:.:.|||::||||::||.:||..:||..||..:...:|..
  Rat   505 LGADDSYYTARSAGKWPLKWYAPECINFRKFSSRSDVWSYGVTMWEAFSYGQKPYKKMKGPEVLD 569

  Fly   598 KLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL 640
            .:.:|.|||.||.||||:|.||..||.:...|||.|.::...:
  Rat   570 FIKQGKRMECPPECPPEMYALMSDCWIYKWEDRPDFVAVEQRM 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189 37/133 (28%)
PTKc_Abl 382..644 CDD:270645 105/273 (38%)
FABD 1584..1723 CDD:197885
Zap70XP_006244823.1 SH2_N-SH2_Zap70_Syk_like 32..135 CDD:198191
SH2 176..280 CDD:472789 34/97 (35%)
PTKc_Zap-70 352..620 CDD:270686 104/263 (40%)
Blue background indicates that the domain is not in the aligned region.

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