Protein Alignment Abl and Srms

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001011961.1
• Gene: Srms / 296472
• RGDID: 1306602
• Length: 507
• Species: Rattus norvegicus
• Alignment Length: 472
• Identity: 194/472 - (41%)
• Similarity: 272/472 - (57%)
• Gaps: 37/472 - (7%)

  Fly   200 PGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSG--NVGWVPSNYV- 261
            |.|.   .:||.|||||.|....:||:.:|:  |:.:..:.||:..|...||  :.|.||..|:
  Rat    64 PAPR---ARLFRALYDFTARCAEELSVSRGD--RLYALKEEGEYIFAQRLSGPPSTGLVPVTYLA 123

  Fly   262 --TPLNSLEKHSWYHGPISRNAAEYLLSSGIN--GSFLVRESESSPGQRSISLRYEGRVYHYRIS 322
              || .:.....||...|||..|:.||.|..|  |:||:|.||||.|..|:|:|.:.:|.||||.
  Rat   124 KATP-ETPSDQPWYFNGISRTQAQQLLLSPANAPGAFLIRPSESSIGGYSLSVRAQAKVCHYRIC 187

  Fly   323 EDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLI-TPLLYPAPKQNKPTVFPLSPEPDEWEICR 386
            ..|.|.:::.:...|.:|..|:.::....:   || .|||.|...|     .||:  .||||..|
  Rat   188 MAPSGGLYLQEGRLFPSLDALLAYYKTNWK---LIQNPLLQPCVPQ-----MPLA--QDEWERPR 242

  Fly   387 TDIMMKHKLGGGQYGEVYEAVWKRYGNT-VAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIG 450
            ::.:::.|||.|.:|||:|.:|  .|:| ||||.:|...|.|.|..:|...:|.::|..|::|..
  Rat   243 SEFVLRRKLGEGFFGEVWEGLW--LGSTPVAVKVIKSADMKLADLTKEIEALKSLRHERLIRLHA 305

  Fly   451 VCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARN 515
            :|:...|.||:||.|..|||..:|.|...:.|....||..|.|:|.||||||.|..:||||||||
  Rat   306 ICSLGEPVYIVTELMGKGNLQVYLGSPEGKALSLPHLLGFACQVAEGMSYLEERRVVHRDLAARN 370

  Fly   516 CLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIA 580
            .||||:...||||||||||::||.|:..:|:|.|:||||||...|..||.|||||:||:||:|:.
  Rat   371 VLVGDDLTCKVADFGLARLLKDDVYSPSSGSKIPVKWTAPEAANYRVFSQKSDVWSFGILLYEVF 435

  Fly   581 TYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQ 645
            |||..||..:...:...::.:|||:.||..||.|||.||.:||:....:||||.::...|
  Rat   436 TYGQCPYEGMTNHETLQQISRGYRLPRPAVCPAEVYMLMVECWKGSPEERPTFATLREKL----- 495

  Fly   646 ESSITEAVEKQLNANAT 662
                 .|:.::|:...|
  Rat   496 -----NAINRRLHLGLT 507

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	21/58 (36%)
		SH2_ABL	268..363	CDD:198189	37/97 (38%)
		PTKc_Abl	382..644	CDD:270645	123/262 (47%)
		FABD	1584..1723	CDD:197885
Srms	NP_001011961.1	SH3	70..124	CDD:473055	21/55 (38%)
		SH2	134..212	CDD:472789	32/77 (42%)
		PTKc_Srm_Brk	238..498	CDD:133248	123/271 (45%)