DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abl and ABL2

DIOPT Version :9

Sequence 1:	NP_001261962.1	Gene:	Abl / 45821	FlyBaseID:	FBgn0000017	Length:	1723	Species:	Drosophila melanogaster
Sequence 2:	NP_009298.1	Gene:	ABL2 / 27	HGNCID:	77	Length:	1182	Species:	Homo sapiens

Alignment Length:	1704	Identity:	558/1704 - (32%)
Similarity:	721/1704 - (42%)	Gaps:	578/1704 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 GVASGSGSGGGGGGSGSGLSQRSGGHKDARCNPT-VGLNIFTEHNGTKHSSFRGHPGKYHMNLEA 131
            |.|.|.......|..||..::.||..:|.....| .|.||||:|:
Human     9 GEAPGLQQPQPRGIRGSSAARPSGRRRDPAGRTTETGFNIFTQHD-------------------- 53

  Fly   132 LLQSRPLPHIPAGSTAASLLADAAELQQHQQDSGGLGLQGSSLGG----------GHSSTTSVFE 186
                    |.      ||.:.|              |.:|...||          |.........
Human    54 --------HF------ASCVED--------------GFEGDKTGGSSPEALHRPYGCDVEPQALN 90

  Fly   187 SAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSG 251
            .|.||:||||||  |..|.||.||||||||.|.|:|.||:.|||::|:|.||::|||.|..|.:|
Human    91 EAIRWSSKENLL--GATESDPNLFVALYDFVASGDNTLSITKGEKLRVLGYNQNGEWSEVRSKNG 153

  Fly   252 NVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRV 316
            . |||||||:||:||||||||||||:||:||||||||.||||||||||||||||.||||||||||
Human   154 Q-GWVPSNYITPVNSLEKHSWYHGPVSRSAAEYLLSSLINGSFLVRESESSPGQLSISLRYEGRV 217

  Fly   317 YHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDE 381
            |||||:...||||:||.|::|:||||||||||...:  ||:|.|.|||||.|||||:.:||..|:
Human   218 YHYRINTTADGKVYVTAESRFSTLAELVHHHSTVAD--GLVTTLHYPAPKCNKPTVYGVSPIHDK 280

  Fly   382 WEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLV 446
            ||:.||||.||||||||||||||..|||:|..||||||||||||.:::||:|||:|||:||||||
Human   281 WEMERTDITMKHKLGGGQYGEVYVGVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLV 345

  Fly   447 QLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDL 511
            ||:||||.||||||:||:|.:|||||:||...||.:.||.||||||||:|.|.|||.:|:|||||
Human   346 QLLGVCTLEPPFYIVTEYMPYGNLLDYLRECNREEVTAVVLLYMATQISSAMEYLEKKNFIHRDL 410

  Fly   512 AARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLL 576
            ||||||||:|.:||||||||:|||..|||||||||||||||||||.||||.||.|||||||||||
Human   411 AARNCLVGENHVVKVADFGLSRLMTGDTYTAHAGAKFPIKWTAPESLAYNTFSIKSDVWAFGVLL 475

  Fly   577 WEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALE 641
            ||||||||||||.|||:.||..|:||||||:|.||||:||:|||.||:|...|||:|...|.|.|
Human   476 WEIATYGMSPYPGIDLSQVYDLLEKGYRMEQPEGCPPKVYELMRACWKWSPADRPSFAETHQAFE 540

  Fly   642 HMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTA--------ASGCASSSSATAS 698
            .||.:|||:|.|.::| ..|.|:||..|....:......|.|..        ..|...::..:||
Human   541 TMFHDSSISEEVAEEL-GRAASSSSVVPYLPRLPILPSKTRTLKKQVENKENIEGAQDATENSAS 604

  Fly   699 LSLTPQMVK--KGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTT 761
             ||.|..::  :...|..||        |.:|:..:|.|..  ...|.:.|:...||..   .::
Human   605 -SLAPGFIRGAQASSGSPAL--------PRKQRDKSPSSLL--EDAKETCFTRDRKGGF---FSS 655

  Fly   762 NKQGKQAPAPPKRTSLLSSSRDSTYRE-EDPANARCNFIDDLSTNGIHKLKTANYFSQTLSRNFK 825
            ..:.:.||.||||:        |::|| |:..:.:.....:.|:  :..|:.|:.||.|
Human   656 FMKKRNAPTPPKRS--------SSFREMENQPHKKYELTGNFSS--VASLQHADGFSFT------ 704

  Fly   826 TQIPTHHTHQIRTQQQQQQQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSSSC--SSFLYDIL 888
                                ..||:..:||                      ..|  .||..
Human   705 --------------------PAQQEANLVP----------------------PKCYGGSFAQ--- 724

  Fly   889 FRGLARDINSLTQRYDSETDPAADPDTDATGDSLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGP 953
             |.|..|                                                .||||||.|.
Human   725 -RNLCND------------------------------------------------DGGGGGGSGT 740

  Fly   954 RSSQQHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGA 1018
            ...                                              |.:|:        .|.
Human   741 AGG----------------------------------------------GWSGI--------TGF 751

  Fly  1019 LDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARLNPKAS 1083
            .....:|:.:        |.|.|.                      |.|:...:.|..|.|.
Human   752 FTPRLIKKTL--------GLRAGK----------------------PTASDDTSKPFPRSNS--- 783

  Fly  1084 PIPPQQMIRSNSSGGVTMQNNAAASL------NKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSA 1142
                    .|:.|.|:..|:..|.:|      :|||..||.:              :||.|:.:.
Human   784 --------TSSMSSGLPEQDRMAMTLPRNCQRSKLQLERTVS--------------TSSQPEENV 826

  Fly  1143 SGVASGVQPALANLEFPPPPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQHLHAQLPNNGNISNG 1207
            .         .||        |:.|...|            |||
Human   827 D---------RAN--------DMLPKKSE------------ESA--------------------- 841

  Fly  1208 NGTNNNDSSHNDVSNIAPSVEEASS----RFGVSLRKREPSTDSCSSLGSPPEDLKEKLITEIKA 1268
                            |||.|...:    |...:|..|.||.|...:...||         .:..
Human   842 ----------------APSRERPKAKLLPRGATALPLRTPSGDLAITEKDPP---------GVGV 881

  Fly  1269 AGKDTAPASHLANGS---GIAVVDPVSLLVTELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLK 1330
            ||...||.....||.   |:|.|                    |:..:
Human   882 AGVAAAPKGKEKNGGARLGMAGV--------------------PEDGE----------------- 909

  Fly  1331 KVEPKKMSAPMPKAEPANTIIDFKAHLRRVDKEKEPATPAPAPATVAVANNANCNTTGTLNRKED 1395
                                              :|..|:||.|...:....|
Human   910 ----------------------------------QPGWPSPAKAAPVLPTTHN------------ 928

  Fly  1396 GSKKFSQAMQKTEIKIDVTNSNVEADAGAAGEGDLGKRRSTGSINSLKKLWEQQPPAPDYATSTI 1460
                     .|..:.|..|..:..||....|....|        |..|.|.|.|      .||:.
Human   929 ---------HKVPVLISPTLKHTPADVQLIGTDSQG--------NKFKLLSEHQ------VTSSG 970

  Fly  1461 LQQQPSVVNGGGTPNAQLSPKYGMKSGAINTVGTLPAKLGNKQPPAAPPPPPPNCTTSNSSTTSI 1525
            .:.:|..|                                  :|..||||||......:.|.
Human   971 DKDRPRRV----------------------------------KPKCAPPPPPVMRLLQHPSI--- 998

  Fly  1526 STSSRDCTSRQQASSTIKTSHSTQLFTDDEEQSHTEGLG----SGGQGSADMTQSLYEQKPQIQQ 1586
                  |:...:..:.:....||   ::.:|......||    ||..|...|      ..||: .
Human   999 ------CSDPTEEPTALTAGQST---SETQEGGKKAALGAVPISGKAGRPVM------PPPQV-P 1047

  Fly  1587 KPAVPHKPTKLT--IYATPIA--KLTEPASSASSTQISRESILELVGLLEGSLKHPV-NAIAGSQ 1646
            .|.....|.|:.  ...|.:|  |..:.|...|:.:||:|::||...||..:|..|| |:
Human  1048 LPTSSISPAKMANGTAGTKVALRKTKQAAEKISADKISKEALLECADLLSSALTEPVPNS----- 1107

  Fly  1647 WLQLSDKLNILHNSCVIFAENGAMP-PHSKFQFRELVTRVEAQSQHLR-SAGSKNVQDNERLVAE 1709
              ||.|..:.|.:.|..:.:  .:| ..:||.|||.|:::|...|.|: |:.:..|.....::..
Human  1108 --QLVDTGHQLLDYCSGYVD--CIPQTRNKFAFREAVSKLELSLQELQVSSAAAGVPGTNPVLNN 1168

  Fly  1710 VGQSLRQISNALNR 1723
            :...:::||:.:.|
Human  1169 LLSCVQEISDVVQR 1182

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	33/53 (62%)
		SH2_ABL	268..363	CDD:198189	72/94 (77%)
		PTKc_Abl	382..644	CDD:270645	195/261 (75%)
		Pkinase_Tyr	389..640	CDD:285015	188/250 (75%)
		FABD	1584..1723	CDD:197885	38/145 (26%)
ABL2	NP_009298.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		11/37 (30%)
		CAP	2..106		35/146 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	60..80		5/33 (15%)
		SH3_Abl	111..164	CDD:212784	33/53 (62%)
		SH2_ABL	169..262	CDD:198189	72/94 (77%)
		PTKc_Abl	281..543	CDD:270645	195/261 (75%)
		Pkinase_Tyr	288..539	CDD:285015	188/250 (75%)
		Kinase activation loop. /evidence=ECO:0000250	427..451		20/23 (87%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	611..641		7/39 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	654..674		7/27 (26%)
		Nuclear localization signal. /evidence=ECO:0000255	658..660		0/1 (0%)
		F-actin-binding. /evidence=ECO:0000250	694..930		84/611 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	763..794		10/63 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	807..851		20/123 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	964..1024		17/111 (15%)
		F-actin-binding. /evidence=ECO:0000250	1020..1182		47/177 (27%)
		FABD	1063..1182	CDD:197885	35/127 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	420	1.000	Domainoid score	I635
eggNOG	1	0.900	-	-		E2759_KOG4278
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	768	1.000	Inparanoid score	I541
Isobase	1	0.950	-	0	Normalized mean entropy	S2819
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000006
OrthoInspector	1	1.000	-	-		otm42072
orthoMCL	1	0.900	-	-		OOG6_100013
Panther	1	1.100	-	-	O	PTHR24418
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4932
SonicParanoid	1	1.000	-	-		X88
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.800