Protein Alignment Abl and Map3k12

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_033608.3
• Gene: Map3k12 / 26404
• MGIID: 1346881
• Length: 888
• Species: Mus musculus
• Alignment Length: 1015
• Identity: 218/1015 - (21%)
• Similarity: 348/1015 - (34%)
• Gaps: 357/1015 - (35%)

  Fly   378 EPDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAI--MKEM 440
            :.|.||:...:|:....:|.|..|.|:  :.:.:|..||||.:::        |:|..|  ::::
Mouse   147 QEDLWEVPFEEILDLQWVGSGAQGAVF--LGRFHGEEVAVKKVRD--------LKETDIKHLRKL 201

  Fly   441 KHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRN 505
            ||||::...||||:.|.:.|:.||.:.|.|.:.|| |||....:: |:..:..||.||:||....
Mouse   202 KHPNIITFKGVCTQAPCYCILMEFCAQGQLYEVLR-AGRPVTPSL-LVDWSMGIAGGMNYLHLHK 264

  Fly   506 YIHRDLAARNCLVGDNKLVKVADFGLARLMRD-DTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDV 569
            .|||||.:.|.|:..:.:||::|||.::.:.| .|..:.||.   :.|.|||.:.....|.|.|:
Mouse   265 IIHRDLKSPNMLITYDDVVKISDFGTSKELSDKSTKMSFAGT---VAWMAPEVIRNEPVSEKVDI 326

  Fly   570 WAFGVLLWEIATYGMSPYPAIDLTDVYHKL-DKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTF 633
            |:|||:|||:.| |..||..:|.:.:...: .....:..|..||.....|:||||.....:||:|
Mouse   327 WSFGVVLWELLT-GEIPYKDVDSSAIIWGVGSNSLHLPVPSSCPDGFKILLRQCWNSKPRNRPSF 390

  Fly   634 KSIHHALEHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSATAS 698
            :.|   |.|:                                                 ..|:|.
Mouse   391 RQI---LLHL-------------------------------------------------DIASAD 403

  Fly   699 LSLTPQMVKKGLPGGQALTPNAHHNDPHQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNK 763
            :..|||                               ||        .|.||.:
Mouse   404 VLSTPQ-------------------------------ET--------YFKSQAE----------- 418

  Fly   764 QGKQAPAPPKRTSLLSSSRDSTYREEDPANARCNFIDDLSTNG--IHKLKTANYFSQTLSRNFKT 826
                                  :|||    .:.:| :.:.:.|  :|:|:      :.|....:.
Mouse   419 ----------------------WREE----VKLHF-EKIKSEGTCLHRLE------EELVMRRRE 450

  Fly   827 QIPTHHTHQIRTQQQQQ-QQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLYDILFR 890
            ::  .|...||...::: :::.....::..|.:|.:..:::..:::.::::  .|...|.....|
Mouse   451 EL--RHALDIREHYERKLERANNLYMELNALMLQLELKERELLRREQALER--RCPGLLKSHPSR 511

  Fly   891 GLARDINSLTQRYDSETDP------AADPD---TDATGDSLEQSLSQVIAAPVTNKMQHSLHSGG 946
            ||... |::.:.......|      :..||   |::....|:.:||.|               |.
Mouse   512 GLLHG-NTMEKLIKKRNVPQKLSPHSKRPDILKTESLLPKLDAALSGV---------------GL 560

  Fly   947 GGGGIGPRSSQQHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSA 1011
            .|...||.|             |....|| :||..|.|...|....||..:..|.|...|:.:
Mouse   561 PGCPKGPPS-------------PGRSRRG-KTRHRKASAKGSCGDLPGLRAALPPHEPGGLGS-- 609

  Fly  1012 HPITVGALDVMNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAA 1076
                                   |.|..:|                        |:...|.|||.
Mouse   610 -----------------------PGGLGVG------------------------PSAWDACPPAL 627

  Fly  1077 RLNPKASPIPPQQMIRSNSSGGVTMQNNAAASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRS 1141
            |      .:....::|..||....:.:.|..:     |.|..|.|.       |..||
Mouse   628 R------GLHHDLLLRKMSSSSPDLLSAALGA-----RGRGATGGA-------RDPGS------- 667

  Fly  1142 ASGVASGVQPALANLEFPPPPL-DLPPPPEEFEG-----------GPPPPPPAPESAVQAIQQHL 1194
                             ||||. |.||......|           |.||||..|...|
Mouse   668 -----------------PPPPQGDTPPSEGSAPGSTSPDSPGGAKGEPPPPVGPGEGV------- 708

  Fly  1195 HAQLPNNGNISNGNGTNNNDSSH-NDVSNIAPSVEEASSRFGVSLRKREPSTD------------ 1246
             ..|......:.|.|.|...|.| ...:.:..:....|.:.|:|..:.|...|
Mouse   709 -GLLGTGREGTAGRGGNRAGSQHLTPAALLYRAAVTRSQKRGISSEEEEGEVDSEVELPPSQRWP 772

  Fly  1247 -------SCSSLGSP-PEDLKEKLITEIKAAG--------KDTAPASH----LANGSGIAVVDPV 1291
                   |.|:..|. |.|::|...:|...:|        .|..|...    .:.||.|.:..|.
Mouse   773 QGPNMRQSLSTFSSENPSDVEEGTASEPSPSGTPEVGSTNTDERPDERSDDMCSQGSEIPLDLPT 837

  Fly  1292 SLLVTELAESMNLPK-------PPPQQQQ----KLTNGNS 1320
            |.:|.| .|:.:||.       |.|:...    :|.|.||
Mouse   838 SEVVPE-REASSLPMQHQDGQGPNPEDSDCDSTELDNSNS 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784
		SH2_ABL	268..363	CDD:198189
		PTKc_Abl	382..644	CDD:270645	90/265 (34%)
		FABD	1584..1723	CDD:197885
Map3k12	NP_033608.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	26..104
		STKc_MAP3K12_13	164..400	CDD:270961	87/303 (29%)
		Leucine-zipper 1	423..444		4/27 (15%)
		Leucine-zipper 2	476..497		2/20 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	557..612		20/108 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	654..888		59/263 (22%)