DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Jak3

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_036987.2 Gene:Jak3 / 25326 RGDID:2940 Length:1100 Species:Rattus norvegicus


Alignment Length:666 Identity:176/666 - (26%)
Similarity:261/666 - (39%) Gaps:186/666 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 KYHMNLEALLQSR---PLP-HIPAGSTAASLL-----ADAAELQQHQQDSGGLGLQGSSLGGGHS 179
            |...||..:.:.|   |.| |.|:......|.     ||:.|..::.               ||.
  Rat   477 KEKSNLIVVRRGRNPTPAPGHSPSCCALTKLSFHTIPADSLEWHENL---------------GHG 526

  Fly   180 STTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQ-----------AGGENQLS-------- 225
            |.|.:|. .||   :|  :..| |..|.::.:.:.|.:           |...:|:|        
  Rat   527 SFTKIFH-GHR---RE--VVDG-ETHDTEVLLKVMDSRHQNCMESFLEAASLMSQVSYPHLVLLH 584

  Fly   226 --LKKGEQVRILSY----------NKSGEWCEAHSDSGNVGW---VPSNYVTPLNSLEKHSWYHG 275
              ...|:.:.:..:          .|.|....|       .|   |.......||.||.....||
  Rat   585 GVCMAGDSIMVQEFVYLGAIDTYLRKRGHLVPA-------SWKLQVTKQLAYALNYLEDKGLPHG 642

  Fly   276 PISRNAAEYLLS-SGINGS--FLVRESESSPG-----------------------QRSISLRYE- 313
            .:|  |.:.||: .|::|:  |:   ..|.||                       |.:.:|..| 
  Rat   643 NVS--ARKVLLAREGVDGNPPFI---KLSDPGVSPTVLSLEMLTDRIPWVAPECLQEAGTLNLEA 702

  Fly   314 --------------GRVYHYRISEDPDGKVFVTQE------AKFNTLAELV------------HH 346
                          |...|. .|.:|..|:...::      .|:..|..|:            ..
  Rat   703 DKWGFGATTWEVFSGAPMHI-TSLEPAKKLKFYEDRGQLPALKWTELEGLIAQCMAYDPGRRPSF 766

  Fly   347 HSVPHEGHGLIT---PLLYPAPKQNKPTVFPLSPEP-DE------WEICRTDIMMKHK------- 394
            .::..:.:||||   .||      :.||  |..|.| ||      ...|:...:.:.:       
  Rat   767 RAILRDLNGLITSDYELL------SDPT--PGIPNPRDELCGGAQLYACQDPAIFEERHLKYISL 823

  Fly   395 LGGGQYGEV----YEAVWKRYGNTVAVKTLKED-TMALKDFLEEAAIMKEMKHPNLVQLIGVC-- 452
            ||.|.:|.|    |:.:....|..||||.|:.. ....:||..|..|:|.:....:|:..||.  
  Rat   824 LGKGNFGSVELCRYDPLGDNTGPLVAVKQLQHSGPEQQRDFQREIQILKALHCDFIVKYRGVSYG 888

  Fly   453 TREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCL 517
            .......::.|::..|.|.|||: ..|..|....||..|.||..||.||.:|..:||||||||.|
  Rat   889 PGRQSLRLVMEYLPSGCLRDFLQ-RHRARLHNDRLLLFAWQICKGMEYLGARRCVHRDLAARNIL 952

  Fly   518 VGDNKLVKVADFGLARL--MRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIA 580
            |.....||:||||||:|  :..|.|......:.||.|.|||.|:.|.||.:||||:|||:|:|:.
  Rat   953 VESEAHVKIADFGLAKLLPLGKDYYVVREPGQSPIFWYAPESLSDNIFSRQSDVWSFGVVLYELF 1017

  Fly   581 TY---GMSPY--------PAIDLTDVYHKLD---KGYRMERPPGCPPEVYDLMRQCWQWDATDRP 631
            ||   ..||.        |..:.:.:.|.|:   :|.|:..|..||.||.:||:.||..:..|||
  Rat  1018 TYSDKSCSPSTEFLRMMGPEREGSPLCHLLELLAEGRRLPPPSTCPTEVQELMQLCWSPNPQDRP 1082

  Fly   632 TFKSIHHALEHMFQES 647
            .|.::...|:.:::.|
  Rat  1083 AFDTLSPQLDALWRGS 1098

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 10/87 (11%)
SH2_ABL 268..363 CDD:198189 30/156 (19%)
PTKc_Abl 382..644 CDD:270645 102/291 (35%)
FABD 1584..1723 CDD:197885
Jak3NP_036987.2 cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..223
FERM_F1 41..114 CDD:465733
FERM_B-lobe 126..245 CDD:481193
FERM_C_JAK3 250..359 CDD:275413
SH2 359..455 CDD:472789
Protein Kinases, catalytic domain 517..774 CDD:473864 49/291 (17%)
Protein Kinases, catalytic domain 813..1095 CDD:473864 101/282 (36%)
Blue background indicates that the domain is not in the aligned region.

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