Protein Alignment Abl and Fyn

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_006256584.1
• Gene: Fyn / 25150
• RGDID: 2641
• Length: 575
• Species: Rattus norvegicus
• Alignment Length: 487
• Identity: 218/487 - (44%)
• Similarity: 303/487 - (62%)
• Gaps: 29/487 - (5%)

  Fly   168 GLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQV 232
            |.||.::.||.:|      |:|..|.:..      ......|||||||::|..|:.||..|||:.
  Rat    95 GGQGLTVFGGVNS------SSHTGTLRTR------GGTGVTLFVALYDYEARTEDDLSFHKGEKF 147

  Fly   233 RILSYNKSGEWCEAHS-DSGNVGWVPSNYVTPLNSLEKHSWYHGPISRNAAE-YLLSSG-INGSF 294
            :||: :..|:|.||.| .:|..|::|||||.|::|::...||.|.:.|..|| .|||.| ..|:|
  Rat   148 QILN-SSEGDWWEARSLTTGETGYIPSNYVAPVDSIQAEEWYFGKLGRKDAERQLLSFGNPRGTF 211

  Fly   295 LVRESESSPGQRSISLR----YEG-RVYHYRISEDPDGKVFVTQEAKFNTLAELVHHHSVPHEGH 354
            |:||||::.|..|:|:|    .:| .|.||:|.:..:|..::|..|:|.||.:||.|:|  ....
  Rat   212 LIRESETTKGAYSLSIRDWDDMKGDHVKHYKIRKLDNGGYYITTRAQFETLQQLVQHYS--ERAA 274

  Fly   355 GLITPLLYPAPKQNKPTVFPLSPE-PDEWEICRTDIMMKHKLGGGQYGEVYEAVWKRYGNT-VAV 417
            ||...|:.|..| ..|.:..||.: .|.|||.|..:.:..:||.||:|||:...|.  ||| ||:
  Rat   275 GLCCRLVVPCHK-GMPRLTDLSVKTKDVWEIPRESLQLIKRLGNGQFGEVWMGTWN--GNTKVAI 336

  Fly   418 KTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNLLDFLRSAGRETL 482
            ||||..||:.:.|||||.|||::||..||||..|.:.| |.||:||:|:.|:|||||:......|
  Rat   337 KTLKPGTMSPESFLEEAQIMKKLKHDKLVQLYAVVSEE-PIYIVTEYMNKGSLLDFLKDGEGRAL 400

  Fly   483 DAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDTYTAHAGAK 547
            ....|:.||.|:|:||:|:|..|||||||.:.|.|||:..:.|:||||||||:.|:.|||..|||
  Rat   401 KLPNLVDMAAQVAAGMAYIERMNYIHRDLRSANILVGNGLICKIADFGLARLIEDNEYTARQGAK 465

  Fly   548 FPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCP 612
            |||||||||...|.:|:.|||||:||:||.|:.|.|..|||.::..:|..::::||||..|..||
  Rat   466 FPIKWTAPEAALYGRFTIKSDVWSFGILLTELVTKGRVPYPGMNNREVLEQVERGYRMPCPQDCP 530

  Fly   613 PEVYDLMRQCWQWDATDRPTFKSIHHALEHMF 644
            ..:::||..||:.|..:||||:.:...||..|
  Rat   531 ISLHELMIHCWKKDPEERPTFEYLQGFLEDYF 562

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	28/54 (52%)
		SH2_ABL	268..363	CDD:198189	39/101 (39%)
		PTKc_Abl	382..644	CDD:270645	133/262 (51%)
		FABD	1584..1723	CDD:197885
Fyn	XP_006256584.1	SH3_Fyn_Yrk	123..178	CDD:212939	28/55 (51%)
		SH2_Src_Fyn_isoform_a_like	183..283	CDD:198281	39/101 (39%)
		PTKc_Fyn	299..572	CDD:270655	135/267 (51%)