Protein Alignment Abl and ABL1

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_009297.2
• Gene: ABL1 / 25
• HGNCID: 76
• Length: 1149
• Species: Homo sapiens
• Alignment Length: 1336
• Identity: 508/1336 - (38%)
• Similarity: 641/1336 - (47%)
• Gaps: 384/1336 - (28%)

  Fly    81 GSGSGLSQRSGGHKDARCNPTVGLNIFTEHNGTKHSSFRGHPGKYHMNLEALLQSRPLPHIPAGS 145
            |:|...|.|.||   ..|      |:|.||                   |||  .||:
Human    25 GAGKKESSRHGG---PHC------NVFVEH-------------------EAL--QRPV------- 52

  Fly   146 TAASLLADAAELQQHQQDSGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLF 210
                    |::.:.          ||.|             .|.||.||||||| ||.|:||.||
Human    53 --------ASDFEP----------QGLS-------------EAARWNSKENLLA-GPSENDPNLF 85

  Fly   211 VALYDFQAGGENQLSLKKGEQVRILSYNKSGEWCEAHSDSGNVGWVPSNYVTPLNSLEKHSWYHG 275
            ||||||.|.|:|.||:.|||::|:|.||.:||||||.:.:|. |||||||:||:|||||||||||
Human    86 VALYDFVASGDNTLSITKGEKLRVLGYNHNGEWCEAQTKNGQ-GWVPSNYITPVNSLEKHSWYHG 149

  Fly   276 PISRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRISEDPDGKVFVTQEAKFNTL 340
            |:||||||||||||||||||||||||||||||||||||||||||||:...|||::|:.|::||||
Human   150 PVSRNAAEYLLSSGINGSFLVRESESSPGQRSISLRYEGRVYHYRINTASDGKLYVSSESRFNTL 214

  Fly   341 AELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLGGGQYGEVYE 405
            ||||||||...:  ||||.|.|||||:|||||:.:||..|:||:.||||.|||||||||||||||
Human   215 AELVHHHSTVAD--GLITTLHYPAPKRNKPTVYGVSPNYDKWEMERTDITMKHKLGGGQYGEVYE 277

  Fly   406 AVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFYIITEFMSHGNL 470
            .|||:|..||||||||||||.:::||:|||:|||:||||||||:||||||||||||||||::|||
Human   278 GVWKKYSLTVAVKTLKEDTMEVEEFLKEAAVMKEIKHPNLVQLLGVCTREPPFYIITEFMTYGNL 342

  Fly   471 LDFLRSAGRETLDAVALLYMATQIASGMSYLESRNYIHRDLAARNCLVGDNKLVKVADFGLARLM 535
            ||:||...|:.::||.||||||||:|.|.|||.:|:|||||||||||||:|.|||||||||:|||
Human   343 LDYLRECNRQEVNAVVLLYMATQISSAMEYLEKKNFIHRDLAARNCLVGENHLVKVADFGLSRLM 407

  Fly   536 RDDTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLD 600
            ..|||||||||||||||||||.|||||||.|||||||||||||||||||||||.|||:.||..|:
Human   408 TGDTYTAHAGAKFPIKWTAPESLAYNKFSIKSDVWAFGVLLWEIATYGMSPYPGIDLSQVYELLE 472

  Fly   601 KGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHALEHMFQESSITEAVEKQLN----ANA 661
            |.||||||.|||.:||:|||.||||:.:|||:|..||.|.|.|||||||::.|||:|.    ..|
Human   473 KDYRMERPEGCPEKVYELMRACWQWNPSDRPSFAEIHQAFETMFQESSISDEVEKELGKQGVRGA 537

  Fly   662 TSASSSAPSTSGVATGGGATTTTAASGCASSSSATASLSLTPQMVKKG-------LPGGQALTPN 719
            .|....||.         ..|.|..|..|:....|..:...|....:|       .|....|.|.
Human   538 VSTLLQAPE---------LPTKTRTSRRAAEHRDTTDVPEMPHSKGQGESDPLDHEPAVSPLLPR 593

  Fly   720 AHHNDP----HQQQASTPMSETGSTSTKLSTFSSQGKGNVQMRRTTNKQGKQAPAPPKRTSLLSS 780
            .....|    ::.:...|..:      |.:.||:..|          |:.|.||.||||:
Human   594 KERGPPEGGLNEDERLLPKDK------KTNLFSALIK----------KKKKTAPTPPKRS----- 637

  Fly   781 SRDSTYREEDPANARCNFID----DLSTNGI--HKLKTANYFSQTLSRNFKTQIPTHHTHQIRTQ 839
               |::||.|....|....:    |:|...:  ..|.||:........| ...:|   ...:|..
Human   638 ---SSFREMDGQPERRGAGEEEGRDISNGALAFTPLDTADPAKSPKPSN-GAGVP---NGALRES 695

  Fly   840 QQQQQQSVQQQQQIVPLSVQQQAHQQQQKQQQYSIKKSSSCSSFLY-----DILFRG--LARDIN 897
            .....:|....::...|:..:.|..:::.....|.:...|||:...     |..:|.  |.||:.
Human   696 GGSGFRSPHLWKKSSTLTSSRLATGEEEGGGSSSKRFLRSCSASCVPHGAKDTEWRSVTLPRDLQ 760

  Fly   898 SLTQRYDSET------DPAADPDTDATGDSLEQSLSQVIAAPVTNKMQHSLHSGGGGGGIGPRSS 956
            |..:::||.|      :..|.|...|..:..:|.....:..|
Human   761 STGRQFDSSTFGGHKSEKPALPRKRAGENRSDQVTRGTVTPP----------------------- 802

  Fly   957 QQHSSFKRPTGTPVMGNRGLETRQSKRSQLHSQAPGPGPPSTQPHHGNNGVVTSAHPITVGALDV 1021
                        |.:..:..|........:...:||..||:..|.       .....:||.....
Human   803 ------------PRLVKKNEEAADEVFKDIMESSPGSSPPNLTPK-------PLRRQVTVAPASG 848

  Fly  1022 MNVKQVVNRYGTLPKGARIGAYLDSLEDSSEAAPALPATAPSLPPANGHATPPAARLNPKASPIP 1086
            :..|:...      ||:.:|.                               |||     |.|:.
Human   849 LPHKEEAG------KGSALGT-------------------------------PAA-----AEPVT 871

  Fly  1087 PQQMIRSNSSGGVTMQNNAAASLNKLQRHRTTTEGTMMTFSSFRAGGSSSSPKRSASGVASGVQP 1151
            |.....|.:.||.   :...|..::::||:                .||.||.|. .|..|.::|
Human   872 PTSKAGSGAPGGT---SKGPAEESRVRRHK----------------HSSESPGRD-KGKLSRLKP 916

  Fly  1152 ALANLEFPPPPLDLPPPPEEFEGGPPPPPPAPESAVQAIQQHLHAQLPNNGNISNGNGTNNNDSS 1216
            |      ||||   |.......||.|...|:.|:|.:|:
Human   917 A------PPPP---PAASAGKAGGKPSQSPSQEAAGEAV-------------------------- 946

  Fly  1217 HNDVSNIAPSVEEASSRFGVSLRKREPSTDSCSSLGSPPEDLKEKLITEIKAAGKDTAPASHLAN 1281
                                              ||:     |.|..:.:.|...|.|
Human   947 ----------------------------------LGA-----KTKATSLVDAVNSDAA------- 965

  Fly  1282 GSGIAVVDPVSLLVTELAESMNLPKPPPQQQQKLTNGNSTGSGFKAQLKKVEPKKMSAPMPKAEP 1346
                                    ||           :..|.|.|..:....||..|     |:|
Human   966 ------------------------KP-----------SQPGEGLKKPVLPATPKPQS-----AKP 990

  Fly  1347 ANTIIDFKAHLRRVDKEKEPATPAPAPATVAVANNA 1382
            :.|                |.:|||.|:|:..|::|
Human   991 SGT----------------PISPAPVPSTLPSASSA 1010

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	34/53 (64%)
		SH2_ABL	268..363	CDD:198189	75/94 (80%)
		PTKc_Abl	382..644	CDD:270645	201/261 (77%)
		FABD	1584..1723	CDD:197885
ABL1	NP_009297.2	SH3_Abl	84..137	CDD:212784	34/53 (64%)
		SH2_ABL	142..235	CDD:198189	75/94 (80%)
		PTKc_Abl	254..516	CDD:270645	201/261 (77%)
		FABD	1025..1149	CDD:197885