DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Ripk3

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_647558.2 Gene:Ripk3 / 246240 RGDID:628899 Length:478 Species:Rattus norvegicus


Alignment Length:470 Identity:116/470 - (24%)
Similarity:175/470 - (37%) Gaps:121/470 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   395 LGGGQYGEVYEAVWKRYGNTVAVKTLKEDTMALKDFLEEAAIMKEMKHPNLVQLIGVCTREPPFY 459
            :|.|.:|.|:.|....:...||||.:..     |....|...|..::|.|::.|:||.......|
  Rat    28 VGKGGFGAVFRARHTAWNLDVAVKIVNS-----KKISREVKAMVNLRHENVLLLLGVTENLEWDY 87

  Fly   460 I-----ITEFMSHGNLLDFLR-SAGRETLDAVALLYMATQIASGMSYLESRN--YIHRDLAARNC 516
            :     :|.||.:|:|...|: |..|..   ..|..:..::..||.||.|.|  .:||||...|.
  Rat    88 VYGPALVTGFMENGSLSGLLQPSCPRPW---PLLCRLLEEVVLGMCYLHSLNPSLLHRDLKPSNV 149

  Fly   517 LVGDNKLVKVADFGLARLMRDDTYTAHAGAK---FPIKWTAPEGLAYN-KFSTKSDVWAFGVLLW 577
            |:......|:|||||:.........:.:|::   ..:.:.|||.|..: |.|..|||::||||:|
  Rat   150 LLDPELHAKLADFGLSTFQGGSQSGSGSGSRDSGGTLAYLAPELLDNDGKASKASDVYSFGVLVW 214

  Fly   578 EIATYGMSPYPAIDLTDVYHKLDKG---YRMERPP--GCPPE---------VYDLMRQCWQWDAT 628
            .:.. |... ..:|.|    .|.:|   .|..|||  ..||:         :.:||..||..:..
  Rat   215 TVLA-GREA-EVVDKT----SLIRGAVCNRQRRPPLTELPPDSPETPGLEGLKELMTHCWSSEPK 273

  Fly   629 DRPTFKSIHHALEHMF--QESSITEAVEK-------------QLNANATS--------------- 663
            |||:|:.......:::  .:..:..||.|             :|:|..:|               
  Rat   274 DRPSFQDCESKTNNVYILVQDKVDAAVSKVKHYLSQYRSSDTKLSARESSQKGTEVDCPRETIVY 338

  Fly   664 ----------ASSSAP-------------STSGVATGGGATTTTAASGCASSSSATASLSLTPQM 705
                      .|.|.|             ::.|.||..|.::.|.| |.........|...||:.
  Rat   339 EMLDRLHLEEPSGSVPERLTSLTERRGKEASFGHATPAGTSSDTLA-GTPQIPHTLPSRGTTPRP 402

  Fly   706 VKKGLPGGQALTPNAHHNDPHQQQ-------------ASTPMSETGSTSTKLSTFSSQ--GKGNV 755
            .....||          .||.:.|             |..||  ||..|..|:..|..  |:.|.
  Rat   403 AFTETPG----------PDPQRNQGDGRNSNPWYTWNAPNPM--TGLQSIVLNNCSEVQIGQHNC 455

  Fly   756 QMRRTTNKQGKQAPA 770
            ...:......|:.||
  Rat   456 MSVQPRTAFPKKEPA 470

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784
SH2_ABL 268..363 CDD:198189
PTKc_Abl 382..644 CDD:270645 79/274 (29%)
FABD 1584..1723 CDD:197885
Ripk3NP_647558.2 Protein Kinases, catalytic domain 28..285 CDD:473864 79/270 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 311..330 3/18 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 362..429 15/77 (19%)
RIP homotypic interaction motif (RHIM). /evidence=ECO:0000250|UniProtKB:Q9Y572 437..461 5/23 (22%)
RHIM 438..458 CDD:463679 5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

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