DRSC/TRiP Functional Genomics Resources

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Protein Alignment Abl and Jak2

DIOPT Version :10

Sequence 1:NP_001261962.1 Gene:Abl / 45821 FlyBaseID:FBgn0000017 Length:1723 Species:Drosophila melanogaster
Sequence 2:NP_113702.1 Gene:Jak2 / 24514 RGDID:2939 Length:1132 Species:Rattus norvegicus


Alignment Length:670 Identity:169/670 - (25%)
Similarity:260/670 - (38%) Gaps:185/670 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly    89 RSGGHKDARCNPTVGLNIFTEHNGTKHSSFRGHPGKYHMNLEALLQSRPLPHIPAGSTAASLLAD 153
            |:.|..|.:.:||:     ..||......|      :.:..|.|:.:..|    ...|...:.. 
  Rat   513 RTNGVSDVQLSPTL-----QRHNNVNQMVF------HKIRNEDLIFNESL----GQGTFTKIFK- 561

  Fly   154 AAELQQHQQDSGGLGLQGSSLGGGHSSTT--SVFESAHRWTSKENLLAPGPEEDDPQLFVALYDF 216
                        |:..:....|..|.:..  .|.:.|||..|:             ..|.|....
  Rat   562 ------------GVRREVGDYGQLHETEVLLKVLDKAHRNYSE-------------SFFEAASMM 601

  Fly   217 QAGGENQLSLKKG------EQVRILSYNKSGE---WCEAHSDSGNVGW---VPSNYVTPLNSLEK 269
            .......|.|..|      |.:.:..:.|.|.   :.:.:.:|.|:.|   |.......::.||:
  Rat   602 SQLSHKHLVLNYGVCVCGEENILVQEFVKFGSLDTYLKKNKNSINILWKLGVAKQLAWAMHFLEE 666

  Fly   270 HSWYHGPISRNAAEYLLSSGINGSFLVRESE-----------SSPGQRSISLRYEGR-VYHYRIS 322
            .|..||.:   .|:.:|        |:||.:           |.||   ||:....: :...||.
  Rat   667 KSLIHGNV---CAKNIL--------LIREEDRKTGNPPFIKLSDPG---ISITVLPKDILQERIP 717

  Fly   323 -------EDPDGKVFVTQEAKF-NTLAELVHHHSVP-------------HEGHGLITPLLYPAPK 366
                   |:|......|.:..| .||.|:......|             .:.|.|      ||||
  Rat   718 WVPPECIENPKNLTLATDKWSFGTTLWEICSGGDKPLSALDSQRKLQFYEDKHQL------PAPK 776

  Fly   367 QNK-----PTVFPLSPE-----------------PDEWEICRTDIMM------------------ 391
            ..:     .|.....|:                 || :|:...:.|:                  
  Rat   777 WTELANLINTCMDYEPDFRPAFRAVIRDLNSLFTPD-YELLTENDMLPNMRIGALGFSGAFEDRD 840

  Fly   392 ------KH-----KLGGGQYGEV----YEAVWKRYGNTVAVKTLKEDTMA-LKDFLEEAAIMKEM 440
                  :|     :||.|.:|.|    |:.:....|..||||.|:..|.. |:||..|..|:|.:
  Rat   841 PTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSL 905

  Fly   441 KHPNLVQLIGVC--TREPPFYIITEFMSHGNLLDFLRSAGRETLDAVALLYMATQIASGMSYLES 503
            :|.|:|:..|||  .......:|.|::.:|:|.|:|:. .:|.:|...||...:||..||.||.:
  Rat   906 QHDNIVKYKGVCYSAGRRNLRLIMEYLPYGSLRDYLQK-HKERIDHKKLLQYTSQICKGMEYLGT 969

  Fly   504 RNYIHRDLAARNCLVGDNKLVKVADFGLARLMRDDT--YTAHAGAKFPIKWTAPEGLAYNKFSTK 566
            :.|||||||.||.||.:...||:.||||.:::..|.  |......:.||.|.|||.|..:|||..
  Rat   970 KRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVA 1034

  Fly   567 SDVWAFGVLLWEIATY-GMSPYPAIDLTD-----------VYHKLD---KGYRMERPPGCPPEVY 616
            ||||:|||:|:|:.|| ..|..|.::...           |:|.::   ...|:.||.|||.|:|
  Rat  1035 SDVWSFGVVLYELFTYIEKSKSPPVEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPEGCPDEIY 1099

  Fly   617 DLMRQCWQWDATDRPTFKSI 636
            .:|.:||..:...||:|:.:
  Rat  1100 VIMTECWNNNVNQRPSFRDL 1119

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AblNP_001261962.1 SH3_Abl 209..263 CDD:212784 12/65 (18%)
SH2_ABL 268..363 CDD:198189 26/127 (20%)
PTKc_Abl 382..644 CDD:270645 102/308 (33%)
FABD 1584..1723 CDD:197885
Jak2NP_113702.1 Interaction with cytokine/interferon/growth hormone receptors. /evidence=ECO:0000250 1..239
FERM_F1 39..134 CDD:465733
FERM_F2 143..261 CDD:436450
FERM_C_JAK2 266..386 CDD:270141
SH2_Jak2 386..482 CDD:198242
PTK_Jak2_rpt1 545..806 CDD:270663 56/310 (18%)
PTKc_Jak2_rpt2 844..1127 CDD:271107 100/277 (36%)
Blue background indicates that the domain is not in the aligned region.

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