Protein Alignment Abl and FGFR3

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: XP_006713931.1
• Gene: FGFR3 / 2261
• HGNCID: 3690
• Length: 811
• Species: Homo sapiens
• Alignment Length: 633
• Identity: 189/633 - (29%)
• Similarity: 286/633 - (45%)
• Gaps: 159/633 - (25%)

  Fly   129 LEALLQSRPLPH-------IPAGSTAASLLADA-------AELQQHQQDSGGLGLQGSSLGGGHS 179
            |:.|.:|   ||       :||..||. |.:|.       ::.|.|.|....:.:.||.:|...:
Human   243 LDVLERS---PHRPILQAGLPANQTAV-LGSDVEFHCKVYSDAQPHIQWLKHVEVNGSKVGPDGT 303

  Fly   180 STTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKKGEQVRILSYNKSGEWC 244
            ...:|.:|   |.|:.       .|.|.:|.:|....:.|||                    ..|
Human   304 PYVTVLKS---WISES-------VEADVRLRLANVSERDGGE--------------------YLC 338

  Fly   245 EAHSDSGNVGWVPSNYVTPLNSLEKHSW--YHGPISRNAAEYL-------------LSSGINGSF 294
            .|           :|::   ...||..|  .|||  |.|.|.|             ||.|: |.|
Human   339 RA-----------TNFI---GVAEKAFWLSVHGP--RAAEEELVEADEAGSVYAGILSYGV-GFF 386

  Fly   295 L------------VRESESSPGQRSISLRYEGRVYHYRISEDP-DGKVFVTQEAKFNTLAELVHH 346
            |            :|    ||.::.:     |....::||..| ..:|.|:.|:..:..:.
Human   387 LFILVVAAVTLCRLR----SPPKKGL-----GSPTVHKISRFPLKRQVTVSLESNASMSSN---- 438

  Fly   347 HSVPHEGHGLITPLLYPA--PKQNKPTVFPLS----PEPDEWEICRTDIMMKHKLGGGQYGEVY- 404
                       |||:..|  .....||:..:|    |...:||:.|..:.:...||.|.:|:|.
Human   439 -----------TPLVRIARLSSGEGPTLANVSELELPADPKWELSRARLTLGKPLGEGCFGQVVM 492

  Fly   405 -EAVW---KRYGN--TVAVKTLKEDT--MALKDFLEEAAIMKEM-KHPNLVQLIGVCTREPPFYI 460
             ||:.   .|...  |||||.||:|.  ..|.|.:.|..:||.: ||.|::.|:|.||:..|.|:
Human   493 AEAIGIDKDRAAKPVTVAVKMLKDDATDKDLSDLVSEMEMMKMIGKHKNIINLLGACTQGGPLYV 557

  Fly   461 ITEFMSHGNLLDFLRS--------------AGRETLDAVALLYMATQIASGMSYLESRNYIHRDL 511
            :.|:.:.|||.:|||:              ...|.|....|:..|.|:|.||.||.|:..|||||
Human   558 LVEYAAKGNLREFLRARRPPGLDYSFDTCKPPEEQLTFKDLVSCAYQVARGMEYLASQKCIHRDL 622

  Fly   512 AARNCLVGDNKLVKVADFGLARLMRD-DTYTAHAGAKFPIKWTAPEGLAYNKFSTKSDVWAFGVL 575
            ||||.||.::.::|:|||||||.:.: |.|......:.|:||.|||.|....::.:||||:||||
Human   623 AARNVLVTEDNVMKIADFGLARDVHNLDYYKKTTNGRLPVKWMAPEALFDRVYTHQSDVWSFGVL 687

  Fly   576 LWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRPTFKSIHHAL 640
            ||||.|.|.||||.|.:.:::..|.:|:||::|..|..::|.:||:||....:.|||||.:...|
Human   688 LWEIFTLGGSPYPGIPVEELFKLLKEGHRMDKPANCTHDLYMIMRECWHAAPSQRPTFKQLVEDL 752

  Fly   641 EHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASG 688
            :.:.   ::|...::.|:.:|.....|        .||..|.::::||
Human   753 DRVL---TVTSTDQEYLDLSAPFEQYS--------PGGQDTPSSSSSG 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	8/53 (15%)
		SH2_ABL	268..363	CDD:198189	29/122 (24%)
		PTKc_Abl	382..644	CDD:270645	115/286 (40%)
		FABD	1584..1723	CDD:197885
FGFR3	XP_006713931.1	Ig	37..109	CDD:472250
		Ig strand B	57..61	CDD:409362
		Ig strand C	69..75	CDD:409362
		Ig strand E	92..96	CDD:409362
		IgI_2_FGFR	151..245	CDD:409443	1/1 (100%)
		Ig strand A	151..154	CDD:409443
		Ig strand A'	162..167	CDD:409443
		Ig strand B	171..179	CDD:409443
		Ig strand C	185..190	CDD:409443
		Ig strand C'	193..195	CDD:409443
		Ig strand D	204..207	CDD:409443
		Ig strand E	211..216	CDD:409443
		Ig strand F	225..232	CDD:409443
		Ig strand G	235..245	CDD:409443	1/1 (100%)
		IgI_3_FGFR	253..354	CDD:409363	29/145 (20%)
		Ig strand A	253..256	CDD:409363	0/2 (0%)
		Ig strand A'	260..264	CDD:409363	2/3 (67%)
		Ig strand B	272..279	CDD:409363	0/6 (0%)
		Ig strand C	283..290	CDD:409363	2/6 (33%)
		Ig strand D	305..310	CDD:409363	1/4 (25%)
		Ig strand E	321..326	CDD:409363	1/4 (25%)
		Ig strand F	334..342	CDD:409363	4/38 (11%)
		Ig strand G	345..353	CDD:409363	2/7 (29%)
		Protein Kinases, catalytic domain	463..797	CDD:473864	125/338 (37%)