Protein Alignment Abl and FGFR1

DIOPT Version :10

• Sequence 1: NP_001261962.1
• Gene: Abl / 45821
• FlyBaseID: FBgn0000017
• Length: 1723
• Species: Drosophila melanogaster
• Sequence 2: NP_001167538.1
• Gene: FGFR1 / 2260
• HGNCID: 3688
• Length: 853
• Species: Homo sapiens
• Alignment Length: 658
• Identity: 187/658 - (28%)
• Similarity: 284/658 - (43%)
• Gaps: 151/658 - (22%)

  Fly   109 EHNGTKHSSFRGHPGKYHMNLEALLQSRPL--PHIPAGSTAASLLADAAEL--------QQHQQD 163
            |:....|:        |.:::......||:  ..:||..|.|  |....|.        |.|.|.
Human   266 EYGSINHT--------YQLDVVERSPHRPILQAGLPANKTVA--LGSNVEFMCKVYSDPQPHIQW 320

  Fly   164 SGGLGLQGSSLGGGHSSTTSVFESAHRWTSKENLLAPGPEEDDPQLFVALYDFQAGGENQLSLKK 228
            ...:.:.||.:|..:.....:.::|            |....|.::.|.
Human   321 LKHIEVNGSKIGPDNLPYVQILKTA------------GVNTTDKEMEVL---------------- 357

  Fly   229 GEQVRILSYNKSGEW-CEAHSDSG---NVGWVPSNYVTPLNSLEKHSWYHGPISRNAAEYL---- 285
              .:|.:|:..:||: |.|.:..|   :..|     :|.|.:||:.     |....:..||
Human   358 --HLRNVSFEDAGEYTCLAGNSIGLSHHSAW-----LTVLEALEER-----PAVMTSPLYLEIII 410

  Fly   286 ------LSSGINGSFLVRESESSPGQ-------------RSISLRYEGRVYHYRISEDPDGKVFV 331
                  |.|.:.||.:|.:.:|...:             :||.||.:     ..:|.|
Human   411 YCTGAFLISCMVGSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQ-----VTVSAD------- 463

  Fly   332 TQEAKFNTLAELVHHHSVPHEGHGLITPLLYPAPKQNKPTVFPLSPEPDEWEICRTDIMMKHKLG 396
             ..|..|:...||....:...|    ||:|....:..       .||...||:.|..:::...||
Human   464 -SSASMNSGVLLVRPSRLSSSG----TPMLAGVSEYE-------LPEDPRWELPRDRLVLGKPLG 516

  Fly   397 GGQYGEVY--EAVW--KRYGN---TVAVKTLKEDTMA--LKDFLEEAAIMKEM-KHPNLVQLIGV 451
            .|.:|:|.  ||:.  |...|   .||||.||.|...  |.|.:.|..:||.: ||.|::.|:|.
Human   517 EGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINLLGA 581

  Fly   452 CTREPPFYIITEFMSHGNLLDFL---RSAG-----------RETLDAVALLYMATQIASGMSYLE 502
            ||::.|.|:|.|:.|.|||.::|   |..|           .|.|.:..|:..|.|:|.||.||.
Human   582 CTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYNPSHNPEEQLSSKDLVSCAYQVARGMEYLA 646

  Fly   503 SRNYIHRDLAARNCLVGDNKLVKVADFGLAR-LMRDDTYTAHAGAKFPIKWTAPEGLAYNKFSTK 566
            |:..|||||||||.||.::.::|:||||||| :...|.|......:.|:||.|||.|....::.:
Human   647 SKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPVKWMAPEALFDRIYTHQ 711

  Fly   567 SDVWAFGVLLWEIATYGMSPYPAIDLTDVYHKLDKGYRMERPPGCPPEVYDLMRQCWQWDATDRP 631
            ||||:||||||||.|.|.||||.:.:.:::..|.:|:||::|..|..|:|.:||.||....:.||
Human   712 SDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPSQRP 776

  Fly   632 TFKSIHHALEHMFQESSITEAVEKQLNANATSASSSAPSTSGVATGGGATTTTAASGCASSSSAT 696
            |||.:...|:.:...:|..|.::  |:......|.|.|.             |.:|.|:|...:.
Human   777 TFKQLVEDLDRIVALTSNQEYLD--LSMPLDQYSPSFPD-------------TRSSTCSSGEDSV 826

  Fly   697 ASLSLTPQ 704
            .|....|:
Human   827 FSHEPLPE 834

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Abl	NP_001261962.1	SH3_Abl	209..263	CDD:212784	9/57 (16%)
		SH2_ABL	268..363	CDD:198189	24/117 (21%)
		PTKc_Abl	382..644	CDD:270645	117/286 (41%)
		FABD	1584..1723	CDD:197885
FGFR1	NP_001167538.1	IgI_1_FGFR	58..151	CDD:409362
		Ig strand A	58..61	CDD:409362
		Ig strand A'	73..79	CDD:409362
		Ig strand B	82..92	CDD:409362
		Ig strand C	96..101	CDD:409362
		Ig strand C'	104..106	CDD:409362
		Ig strand D	111..115	CDD:409362
		Ig strand E	118..123	CDD:409362
		Ig strand F	129..138	CDD:409362
		Ig strand G	141..151	CDD:409362
		IgI_2_FGFR	184..278	CDD:409443	3/19 (16%)
		Ig strand A	184..187	CDD:409443
		Ig strand A'	195..200	CDD:409443
		Ig strand B	204..212	CDD:409443
		Ig strand C	218..223	CDD:409443
		Ig strand C'	226..228	CDD:409443
		Ig strand D	237..240	CDD:409443
		Ig strand E	244..249	CDD:409443
		Ig strand F	258..265	CDD:409443
		Ig strand G	268..278	CDD:409443	2/17 (12%)
		Ig	286..390	CDD:472250	26/140 (19%)
		Ig strand B	304..308	CDD:409353	1/3 (33%)
		Ig strand C	317..321	CDD:409353	2/3 (67%)
		Ig strand E	355..359	CDD:409353	1/21 (5%)
		Ig strand F	369..374	CDD:409353	2/4 (50%)
		Ig strand G	382..385	CDD:409353	0/2 (0%)
		PTKc_FGFR1	495..796	CDD:270678	120/307 (39%)